Limits...
Associations of cardiovascular risk factors, carotid intima-media thickness and manifest atherosclerotic vascular disease with carpal tunnel syndrome.

Shiri R, Heliƶvaara M, Moilanen L, Viikari J, Liira H, Viikari-Juntura E - BMC Musculoskelet Disord (2011)

Bottom Line: Obesity (adjusted odds ratio (OR) 2.4, 95% confidence interval (CI) 1.1-5.4), high LDL cholesterol (OR 3.8, 95% CI 1.6-9.1 for >190 vs. <129 mg/dL), high triglycerides (OR 2.7, 95% CI 1.2-6.1 for >200 vs. <150 mg/dL), hypertension (OR 3.4, 95% CI 1.6-7.4) and cardiac arrhythmia (OR 10.2, 95% CI 2.7-38.4) were associated with CTS in subjects aged 30-44.In the age group of 60 years or over, coronary artery disease (OR 1.9, 95% CI 1.1-3.5), valvular heart disease (OR 2.3, 95% CI 1.0-5.0) and carotid IMT (1.4, 95% CI 0.9-2.1 for each 0.23 mm increase) were associated with CTS.Carotid IMT was associated with CTS only in subjects with hypertension or clinical atherosclerotic vascular disease, or in those who were exposed to physical workload factors.

View Article: PubMed Central - HTML - PubMed

Affiliation: Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Helsinki, Finland. rahman.shiri@ttl.fi

ABSTRACT

Background: The role of atherosclerosis in carpal tunnel syndrome (CTS) has not previously been addressed in population studies. The aim of this study was to investigate the associations of cardiovascular risk factors, carotid artery intima-media thickness (IMT), and clinical atherosclerotic diseases with CTS.

Methods: In this cross sectional study, the target population consisted of subjects aged 30 or over who had participated in the national Finnish Health Survey in 2000-2001. Of the 7977 eligible subjects, 6254 (78.4%) were included in our study. Carotid IMT was measured in a sub-sample of subjects aged 45 to 74 (N=1353).

Results: Obesity (adjusted odds ratio (OR) 2.4, 95% confidence interval (CI) 1.1-5.4), high LDL cholesterol (OR 3.8, 95% CI 1.6-9.1 for >190 vs. <129 mg/dL), high triglycerides (OR 2.7, 95% CI 1.2-6.1 for >200 vs. <150 mg/dL), hypertension (OR 3.4, 95% CI 1.6-7.4) and cardiac arrhythmia (OR 10.2, 95% CI 2.7-38.4) were associated with CTS in subjects aged 30-44. In the age group of 60 years or over, coronary artery disease (OR 1.9, 95% CI 1.1-3.5), valvular heart disease (OR 2.3, 95% CI 1.0-5.0) and carotid IMT (1.4, 95% CI 0.9-2.1 for each 0.23 mm increase) were associated with CTS. Carotid IMT was associated with CTS only in subjects with hypertension or clinical atherosclerotic vascular disease, or in those who were exposed to physical workload factors.

Conclusions: Our findings suggest an association between CTS and cardiovascular risk factors in young people, and carotid IMT and clinical atherosclerotic vascular disease in older people. CTS may either be a manifestation of atherosclerosis, or both conditions may share similar risk factors.

Show MeSH

Related in: MedlinePlus

Age-specific prevalence of possible and probable carpal tunnel syndrome combined according to vascular disease (coronary artery disease, cerebrovascular disease, or intermittent claudication). The difference in prevalence between the two groups was statistically significant for the 50-59, 60-69 and 70-79 year age groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3116486&req=5

Figure 1: Age-specific prevalence of possible and probable carpal tunnel syndrome combined according to vascular disease (coronary artery disease, cerebrovascular disease, or intermittent claudication). The difference in prevalence between the two groups was statistically significant for the 50-59, 60-69 and 70-79 year age groups.

Mentions: Subjects with coronary artery disease, valvular heart disease, intermittent claudication, or cerebrovascular disease had a higher prevalence of possible and probable CTS combined (Table 3, Figure 1) or probable CTS (Table 3) compared with those without such a condition. However, none of these associations was statistically significant. Carotid IMT was associated with an increased prevalence of CTS; the odds ratio (OR) was only statistically significant for probable CTS (OR 1.7, 95% CI 1.1-2.6 for each standard deviation (0.23 mm) increase in IMT). Heart failure and arrhythmia were not associated with CTS. Subjects with coronary artery disease were less likely to be operated on for CTS than those without such a condition.


Associations of cardiovascular risk factors, carotid intima-media thickness and manifest atherosclerotic vascular disease with carpal tunnel syndrome.

Shiri R, Heliƶvaara M, Moilanen L, Viikari J, Liira H, Viikari-Juntura E - BMC Musculoskelet Disord (2011)

Age-specific prevalence of possible and probable carpal tunnel syndrome combined according to vascular disease (coronary artery disease, cerebrovascular disease, or intermittent claudication). The difference in prevalence between the two groups was statistically significant for the 50-59, 60-69 and 70-79 year age groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3116486&req=5

Figure 1: Age-specific prevalence of possible and probable carpal tunnel syndrome combined according to vascular disease (coronary artery disease, cerebrovascular disease, or intermittent claudication). The difference in prevalence between the two groups was statistically significant for the 50-59, 60-69 and 70-79 year age groups.
Mentions: Subjects with coronary artery disease, valvular heart disease, intermittent claudication, or cerebrovascular disease had a higher prevalence of possible and probable CTS combined (Table 3, Figure 1) or probable CTS (Table 3) compared with those without such a condition. However, none of these associations was statistically significant. Carotid IMT was associated with an increased prevalence of CTS; the odds ratio (OR) was only statistically significant for probable CTS (OR 1.7, 95% CI 1.1-2.6 for each standard deviation (0.23 mm) increase in IMT). Heart failure and arrhythmia were not associated with CTS. Subjects with coronary artery disease were less likely to be operated on for CTS than those without such a condition.

Bottom Line: Obesity (adjusted odds ratio (OR) 2.4, 95% confidence interval (CI) 1.1-5.4), high LDL cholesterol (OR 3.8, 95% CI 1.6-9.1 for >190 vs. <129 mg/dL), high triglycerides (OR 2.7, 95% CI 1.2-6.1 for >200 vs. <150 mg/dL), hypertension (OR 3.4, 95% CI 1.6-7.4) and cardiac arrhythmia (OR 10.2, 95% CI 2.7-38.4) were associated with CTS in subjects aged 30-44.In the age group of 60 years or over, coronary artery disease (OR 1.9, 95% CI 1.1-3.5), valvular heart disease (OR 2.3, 95% CI 1.0-5.0) and carotid IMT (1.4, 95% CI 0.9-2.1 for each 0.23 mm increase) were associated with CTS.Carotid IMT was associated with CTS only in subjects with hypertension or clinical atherosclerotic vascular disease, or in those who were exposed to physical workload factors.

View Article: PubMed Central - HTML - PubMed

Affiliation: Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Helsinki, Finland. rahman.shiri@ttl.fi

ABSTRACT

Background: The role of atherosclerosis in carpal tunnel syndrome (CTS) has not previously been addressed in population studies. The aim of this study was to investigate the associations of cardiovascular risk factors, carotid artery intima-media thickness (IMT), and clinical atherosclerotic diseases with CTS.

Methods: In this cross sectional study, the target population consisted of subjects aged 30 or over who had participated in the national Finnish Health Survey in 2000-2001. Of the 7977 eligible subjects, 6254 (78.4%) were included in our study. Carotid IMT was measured in a sub-sample of subjects aged 45 to 74 (N=1353).

Results: Obesity (adjusted odds ratio (OR) 2.4, 95% confidence interval (CI) 1.1-5.4), high LDL cholesterol (OR 3.8, 95% CI 1.6-9.1 for >190 vs. <129 mg/dL), high triglycerides (OR 2.7, 95% CI 1.2-6.1 for >200 vs. <150 mg/dL), hypertension (OR 3.4, 95% CI 1.6-7.4) and cardiac arrhythmia (OR 10.2, 95% CI 2.7-38.4) were associated with CTS in subjects aged 30-44. In the age group of 60 years or over, coronary artery disease (OR 1.9, 95% CI 1.1-3.5), valvular heart disease (OR 2.3, 95% CI 1.0-5.0) and carotid IMT (1.4, 95% CI 0.9-2.1 for each 0.23 mm increase) were associated with CTS. Carotid IMT was associated with CTS only in subjects with hypertension or clinical atherosclerotic vascular disease, or in those who were exposed to physical workload factors.

Conclusions: Our findings suggest an association between CTS and cardiovascular risk factors in young people, and carotid IMT and clinical atherosclerotic vascular disease in older people. CTS may either be a manifestation of atherosclerosis, or both conditions may share similar risk factors.

Show MeSH
Related in: MedlinePlus