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Determination and evaluation of solubility parameter of satranidazole using dioxane-water system.

Rathi PB - Indian J Pharm Sci (2010)

Bottom Line: One of the important methods to improve the solubility and bioavailability of a less water-soluble drug is by the use of cosolvents.The results obtained were compared with the δ(2) values obtained using Molar Volume Method and Fedor's Group Substitution Method.The binary blend water-dioxane (10:90) gave maximum solubility with an experimental δ(2) value of 11.34 (Cal/cm(3))(0.5) that was comparable to the theoretical values of 11.34 (Cal/cm(3))(0.5) determined by Molar Volume Method and 11.3928 (Cal/cm(3))(0.5) when determined by Fedor's Group Substitution Method, which is in good agreement with solubility measurement method.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Shri Bhagwan College of Pharmacy, N-6, CIDCO, Auranagabad-431003, India.

ABSTRACT
Satranidazole, a potent broad spectrum antiprotozoal, is a poorly water-soluble drug and has low bioavailability on oral administration. One of the important methods to improve the solubility and bioavailability of a less water-soluble drug is by the use of cosolvents. The solubility enhancement produced by binary blends with a cosolvent (dioxane) was studied against the solubility parameter of solvent blends (δ(1)) to evaluate the solubility parameter of drug (δ(2)). Solubility parameter of drug (δ(2)) was evaluated in blends of dioxane-water system. The results obtained were compared with the δ(2) values obtained using Molar Volume Method and Fedor's Group Substitution Method. The binary blend water-dioxane (10:90) gave maximum solubility with an experimental δ(2) value of 11.34 (Cal/cm(3))(0.5) that was comparable to the theoretical values of 11.34 (Cal/cm(3))(0.5) determined by Molar Volume Method and 11.3928 (Cal/cm(3))(0.5) when determined by Fedor's Group Substitution Method, which is in good agreement with solubility measurement method.

No MeSH data available.


Related in: MedlinePlus

Solubility parameter versus mole fraction solubility profile of satranidazoleThe solid line (—) represents highest mole fraction solubility (X2=9.6347×10-3) when δ1=11.34 (Cal/cm3)0.5 by molar volume method and (—◆—) represents experimental solubilities by dioxane-water binary solvent system
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Figure 2: Solubility parameter versus mole fraction solubility profile of satranidazoleThe solid line (—) represents highest mole fraction solubility (X2=9.6347×10-3) when δ1=11.34 (Cal/cm3)0.5 by molar volume method and (—◆—) represents experimental solubilities by dioxane-water binary solvent system

Mentions: The molar volume method was used to determine the peak mole fraction solubility of satranidazole in various solvent blends and the mole fraction solubilities X2of satranidazole and Δ δ are tabulated in Table 1. Peak mole fraction solubility was determined to be 9.6347×10-3in solvent blend (water:dioxane, 10:90) with δ1value 11.34 (Cal/cm3)0.5, which is in agreement with the value obtained using solubility measurement method. A plot of δ1 and X2 (fig. 2) showed a bell shaped curve suggesting that both at lower and higher values δ1= 11.34 (Cal/cm3)0.5 the solubility of satranidazole decreased. When Δ δ was plotted against X2 (Fig. 3), the solubility parameter of satranidazole was confirmed at 11.34 (Cal/cm3)0.5as it is that value of δ1 at which Satranidazole exhibited peak mole fraction solubility and Δ δ =0. δ2 determined by the Fedor's group substitution method was found to be 11.3928 (Cal/cm3)0.5, which is comparable to the value obtained by solubility measurement method and molar volume method (Table 2).


Determination and evaluation of solubility parameter of satranidazole using dioxane-water system.

Rathi PB - Indian J Pharm Sci (2010)

Solubility parameter versus mole fraction solubility profile of satranidazoleThe solid line (—) represents highest mole fraction solubility (X2=9.6347×10-3) when δ1=11.34 (Cal/cm3)0.5 by molar volume method and (—◆—) represents experimental solubilities by dioxane-water binary solvent system
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3116322&req=5

Figure 2: Solubility parameter versus mole fraction solubility profile of satranidazoleThe solid line (—) represents highest mole fraction solubility (X2=9.6347×10-3) when δ1=11.34 (Cal/cm3)0.5 by molar volume method and (—◆—) represents experimental solubilities by dioxane-water binary solvent system
Mentions: The molar volume method was used to determine the peak mole fraction solubility of satranidazole in various solvent blends and the mole fraction solubilities X2of satranidazole and Δ δ are tabulated in Table 1. Peak mole fraction solubility was determined to be 9.6347×10-3in solvent blend (water:dioxane, 10:90) with δ1value 11.34 (Cal/cm3)0.5, which is in agreement with the value obtained using solubility measurement method. A plot of δ1 and X2 (fig. 2) showed a bell shaped curve suggesting that both at lower and higher values δ1= 11.34 (Cal/cm3)0.5 the solubility of satranidazole decreased. When Δ δ was plotted against X2 (Fig. 3), the solubility parameter of satranidazole was confirmed at 11.34 (Cal/cm3)0.5as it is that value of δ1 at which Satranidazole exhibited peak mole fraction solubility and Δ δ =0. δ2 determined by the Fedor's group substitution method was found to be 11.3928 (Cal/cm3)0.5, which is comparable to the value obtained by solubility measurement method and molar volume method (Table 2).

Bottom Line: One of the important methods to improve the solubility and bioavailability of a less water-soluble drug is by the use of cosolvents.The results obtained were compared with the δ(2) values obtained using Molar Volume Method and Fedor's Group Substitution Method.The binary blend water-dioxane (10:90) gave maximum solubility with an experimental δ(2) value of 11.34 (Cal/cm(3))(0.5) that was comparable to the theoretical values of 11.34 (Cal/cm(3))(0.5) determined by Molar Volume Method and 11.3928 (Cal/cm(3))(0.5) when determined by Fedor's Group Substitution Method, which is in good agreement with solubility measurement method.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, Shri Bhagwan College of Pharmacy, N-6, CIDCO, Auranagabad-431003, India.

ABSTRACT
Satranidazole, a potent broad spectrum antiprotozoal, is a poorly water-soluble drug and has low bioavailability on oral administration. One of the important methods to improve the solubility and bioavailability of a less water-soluble drug is by the use of cosolvents. The solubility enhancement produced by binary blends with a cosolvent (dioxane) was studied against the solubility parameter of solvent blends (δ(1)) to evaluate the solubility parameter of drug (δ(2)). Solubility parameter of drug (δ(2)) was evaluated in blends of dioxane-water system. The results obtained were compared with the δ(2) values obtained using Molar Volume Method and Fedor's Group Substitution Method. The binary blend water-dioxane (10:90) gave maximum solubility with an experimental δ(2) value of 11.34 (Cal/cm(3))(0.5) that was comparable to the theoretical values of 11.34 (Cal/cm(3))(0.5) determined by Molar Volume Method and 11.3928 (Cal/cm(3))(0.5) when determined by Fedor's Group Substitution Method, which is in good agreement with solubility measurement method.

No MeSH data available.


Related in: MedlinePlus