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Designing of the mucoadhesive intravaginal spermicidal films.

Kawarkhe S, Poddar SS - Indian J Pharm Sci (2010)

Bottom Line: Films were prepared by solvent evaporation method using various compositions of Carbopol, hydroxypropylmethylcellulose, chitosan, Polyox and propylene glycol.All the films possess satisfactory film characteristics.Films made of Polyox found to possess acceptable, physicochemical, mechanical, gelling and mucoadhesion property for delivery of metronidazole.

View Article: PubMed Central - PubMed

Affiliation: Prin. K. M. Kundnani College of Pharmacy, 23, Jote Joy Bldg., Rambhau Salgaonkar Marg, Cuffe Parade, Colaba, Mumbai-400 005, India.

ABSTRACT
A mucoadhesive drug delivery system for local delivery of metronidazole through vaginal route was formulated. Films were prepared by solvent evaporation method using various compositions of Carbopol, hydroxypropylmethylcellulose, chitosan, Polyox and propylene glycol. The films were evaluated for their weight, thickness, surface pH, folding endurance, mechanical, drug content uniformity, in vitro drug release, swelling, gelling and mucoadhesion property. All the films possess satisfactory film characteristics. Films made of Polyox found to possess acceptable, physicochemical, mechanical, gelling and mucoadhesion property for delivery of metronidazole.

No MeSH data available.


Related in: MedlinePlus

In vitro metronidazole releaseValues are expressed as mean; n=3; F1 (–◊–) is carbopol:HPMC (1:1) film; F2 (–□–) is carbopol:HPMC (1:3) film; F3 (—▲—) is HPMC:chitosan fi lm; F4 (—×—) is polyox film
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Figure 1: In vitro metronidazole releaseValues are expressed as mean; n=3; F1 (–◊–) is carbopol:HPMC (1:1) film; F2 (–□–) is carbopol:HPMC (1:3) film; F3 (—▲—) is HPMC:chitosan fi lm; F4 (—×—) is polyox film

Mentions: In the swelling index study, an agar plate was chosen as the simple model of the mucosa as it can keep an amount of water that might resembles the secreting fluid in and around the vagina required for the mucoadhesion and subsequent swelling of the films to provide adequate drug release. The swelling index of the prepared vaginal films was found in the order F3>F1>F2 (Table 3). Batch F4 swelled and was converted into a gel within first 15 min. This might be because of the property of Polyox to get converted into gel after taking up water from the surrounding. Among F1 and F2, initially F1 showed less swelling than F2 however after 90 min, F1 exhibited high swelling than F2. This could be because Carbopol takesup and holds more water than HPMC[12]. Film from batch F3 showed swelling which after an hour lead to conversion into thick mass. The in vitro drug release profiles of metronidazole from polymeric films are shown in fig. 1. To study the release profile of drug VSF was used as dissolution medium to simulate the vaginal conditions. F1 showed prolonged release as compared to other formulations which might be because of high content of the Carbopol. F2 and F4 showed moderate release of drug where as F3 showed fast. The fast release from F3 may be due to faster swelling and disintegration of the polymer network resulting in more void space and fast drug release[10].


Designing of the mucoadhesive intravaginal spermicidal films.

Kawarkhe S, Poddar SS - Indian J Pharm Sci (2010)

In vitro metronidazole releaseValues are expressed as mean; n=3; F1 (–◊–) is carbopol:HPMC (1:1) film; F2 (–□–) is carbopol:HPMC (1:3) film; F3 (—▲—) is HPMC:chitosan fi lm; F4 (—×—) is polyox film
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3116316&req=5

Figure 1: In vitro metronidazole releaseValues are expressed as mean; n=3; F1 (–◊–) is carbopol:HPMC (1:1) film; F2 (–□–) is carbopol:HPMC (1:3) film; F3 (—▲—) is HPMC:chitosan fi lm; F4 (—×—) is polyox film
Mentions: In the swelling index study, an agar plate was chosen as the simple model of the mucosa as it can keep an amount of water that might resembles the secreting fluid in and around the vagina required for the mucoadhesion and subsequent swelling of the films to provide adequate drug release. The swelling index of the prepared vaginal films was found in the order F3>F1>F2 (Table 3). Batch F4 swelled and was converted into a gel within first 15 min. This might be because of the property of Polyox to get converted into gel after taking up water from the surrounding. Among F1 and F2, initially F1 showed less swelling than F2 however after 90 min, F1 exhibited high swelling than F2. This could be because Carbopol takesup and holds more water than HPMC[12]. Film from batch F3 showed swelling which after an hour lead to conversion into thick mass. The in vitro drug release profiles of metronidazole from polymeric films are shown in fig. 1. To study the release profile of drug VSF was used as dissolution medium to simulate the vaginal conditions. F1 showed prolonged release as compared to other formulations which might be because of high content of the Carbopol. F2 and F4 showed moderate release of drug where as F3 showed fast. The fast release from F3 may be due to faster swelling and disintegration of the polymer network resulting in more void space and fast drug release[10].

Bottom Line: Films were prepared by solvent evaporation method using various compositions of Carbopol, hydroxypropylmethylcellulose, chitosan, Polyox and propylene glycol.All the films possess satisfactory film characteristics.Films made of Polyox found to possess acceptable, physicochemical, mechanical, gelling and mucoadhesion property for delivery of metronidazole.

View Article: PubMed Central - PubMed

Affiliation: Prin. K. M. Kundnani College of Pharmacy, 23, Jote Joy Bldg., Rambhau Salgaonkar Marg, Cuffe Parade, Colaba, Mumbai-400 005, India.

ABSTRACT
A mucoadhesive drug delivery system for local delivery of metronidazole through vaginal route was formulated. Films were prepared by solvent evaporation method using various compositions of Carbopol, hydroxypropylmethylcellulose, chitosan, Polyox and propylene glycol. The films were evaluated for their weight, thickness, surface pH, folding endurance, mechanical, drug content uniformity, in vitro drug release, swelling, gelling and mucoadhesion property. All the films possess satisfactory film characteristics. Films made of Polyox found to possess acceptable, physicochemical, mechanical, gelling and mucoadhesion property for delivery of metronidazole.

No MeSH data available.


Related in: MedlinePlus