Limits...
Novel application of hydrotropic solubilizing additives in the estimation of aspirin in tablets.

Maheshwari RK, Saxena M, Gahlot M, Chaki R, Kinariwala M, Jagwani Y - Indian J Pharm Sci (2010)

Bottom Line: Results of analysis by proposed method and Phamacopoeial method are very comparable.Proposed method is new, rapid, simple, accurate, and reproducible.Statistical data proved the accuracy, reproducibility and the precision of proposed method.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, S. G. S. I. T. S., 23 Park Road, Indore-452 003, India.

ABSTRACT
Highly concentrated aqueous solutions of various hydrotropic agents like sodium benzoate, sodium salicylate, sodium acetate, sodium citrate, nicotinamide and sodium ascorbate have been observed to enhance aqueous solubilities of a large number of poorly water-soluble drugs. In the present investigation hydrotropic solubilization technique has been employed to solubilize poorly water-soluble aspirin (analgesic and antipyretic drug) by 0.5 M ibuprofen sodium solution to carry out titrimetric analysis of aspirin in tablet dosage form. Results of analysis by proposed method and Phamacopoeial method are very comparable. Proposed method is new, rapid, simple, accurate, and reproducible. Statistical data proved the accuracy, reproducibility and the precision of proposed method.

No MeSH data available.


Reaction involved during titration of aspirin by proposed method of analysis
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3116315&req=5

Figure 1: Reaction involved during titration of aspirin by proposed method of analysis

Mentions: Hydrotropic solubilization involves addition of large amount of a second solute to increase the aqueous solubility of the first solute. Concentrated aqueous solutions of a large number of hydrotropic agents were successfully used to enhance the aqueous solubility of many poorly water-soluble drugs[1–15]. Sodium benzoate, sodium salicylate, sodium acetate, sodium citrate, nicotinamide and sodium ascorbate are most popular examples of hydrotropic additives. A dramatic increase in the solubility of aspirin (acetyl salicylic acid) in hydrotropic solution of 0.5 M ibuprofen sodium solution was observed. Enhancement in solubility of aspirin in 0.5 M ibuprofen sodium solution was more than 5 fold as compared to solubility in distilled water. Therefore, it was thought worthwhile to solubilize aspirin in hydrotropic solution to carryout titrations with sodium hydroxide solution. Back titration method of Pharmacopoeia[16] is time consuming. Proposed method is rapid and involves direct titration according to the eqn depicted in fig. 1.


Novel application of hydrotropic solubilizing additives in the estimation of aspirin in tablets.

Maheshwari RK, Saxena M, Gahlot M, Chaki R, Kinariwala M, Jagwani Y - Indian J Pharm Sci (2010)

Reaction involved during titration of aspirin by proposed method of analysis
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3116315&req=5

Figure 1: Reaction involved during titration of aspirin by proposed method of analysis
Mentions: Hydrotropic solubilization involves addition of large amount of a second solute to increase the aqueous solubility of the first solute. Concentrated aqueous solutions of a large number of hydrotropic agents were successfully used to enhance the aqueous solubility of many poorly water-soluble drugs[1–15]. Sodium benzoate, sodium salicylate, sodium acetate, sodium citrate, nicotinamide and sodium ascorbate are most popular examples of hydrotropic additives. A dramatic increase in the solubility of aspirin (acetyl salicylic acid) in hydrotropic solution of 0.5 M ibuprofen sodium solution was observed. Enhancement in solubility of aspirin in 0.5 M ibuprofen sodium solution was more than 5 fold as compared to solubility in distilled water. Therefore, it was thought worthwhile to solubilize aspirin in hydrotropic solution to carryout titrations with sodium hydroxide solution. Back titration method of Pharmacopoeia[16] is time consuming. Proposed method is rapid and involves direct titration according to the eqn depicted in fig. 1.

Bottom Line: Results of analysis by proposed method and Phamacopoeial method are very comparable.Proposed method is new, rapid, simple, accurate, and reproducible.Statistical data proved the accuracy, reproducibility and the precision of proposed method.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacy, S. G. S. I. T. S., 23 Park Road, Indore-452 003, India.

ABSTRACT
Highly concentrated aqueous solutions of various hydrotropic agents like sodium benzoate, sodium salicylate, sodium acetate, sodium citrate, nicotinamide and sodium ascorbate have been observed to enhance aqueous solubilities of a large number of poorly water-soluble drugs. In the present investigation hydrotropic solubilization technique has been employed to solubilize poorly water-soluble aspirin (analgesic and antipyretic drug) by 0.5 M ibuprofen sodium solution to carry out titrimetric analysis of aspirin in tablet dosage form. Results of analysis by proposed method and Phamacopoeial method are very comparable. Proposed method is new, rapid, simple, accurate, and reproducible. Statistical data proved the accuracy, reproducibility and the precision of proposed method.

No MeSH data available.