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Design and optimization of floating drug delivery system of acyclovir.

Kharia AA, Hiremath SN, Singhai AK, Omray LK, Jain SK - Indian J Pharm Sci (2010)

Bottom Line: Validity of the developed polynomial equation was verified by designing two check point formulations (C1 and C2).The closeness of predicted and observed values for t(50%) and t(70%) indicates validity of derived equations for the dependent variables.The optimized formulations followed Higuchi's kinetics while the drug release mechanism was found to be anomalous type, controlled by diffusion through the swollen matrix.

View Article: PubMed Central - PubMed

Affiliation: Oriental College of Pharmacy, Raisen Road, Bhopal-462 021, India.

ABSTRACT
The purpose of the present work was to design and optimize floating drug delivery systems of acyclovir using psyllium husk and hydroxypropylmethylcellulose K4M as the polymers and sodium bicarbonate as a gas generating agent. The tablets were prepared by wet granulation method. A 3(2) full factorial design was used for optimization of drug release profile. The amount of psyllium husk (X1) and hydroxypropylmethylcellulose K4M (X2) were selected as independent variables. The times required for 50% (t(50%)) and 70% (t(70%)) drug dissolution were selected as dependent variables. All the designed nine batches of formulations were evaluated for hardness, friability, weight variation, drug content uniformity, swelling index, in vitro buoyancy, and in vitro drug release profile. All formulations had floating lag time below 3 min and constantly floated on dissolution medium for more than 24 h. Validity of the developed polynomial equation was verified by designing two check point formulations (C1 and C2). The closeness of predicted and observed values for t(50%) and t(70%) indicates validity of derived equations for the dependent variables. These studies indicated that the proper balance between psyllium husk and hydroxypropylmethylcellulose K4M can produce a drug dissolution profile similar to the predicted dissolution profile. The optimized formulations followed Higuchi's kinetics while the drug release mechanism was found to be anomalous type, controlled by diffusion through the swollen matrix.

No MeSH data available.


Related in: MedlinePlus

Cumulative percent drug released Vs square root of time (Higuchi's plots) of F1 to F9 formulations.Higuchi's plots for F1 to F9 formulations containing varying psyllium husk:HPMCK4M content; (—□—) F1, 50 mg:50 mg; (—Δ—) F2, 50 mg:75 mg; (—-—) F3, 50 mg:100 mg; (—◊—) F4, 75 mg:50 mg; (—×—) F5, 75 mg:75 mg; (—○—) F6, 75 mg:100 mg; (—*—) F7, 100 mg:50 mg; (—-—) F8, 100 mg:75 mg; (—+—) F9, 100 mg:100 mg. Each data point represents mean ±SD (n=3).
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Figure 2: Cumulative percent drug released Vs square root of time (Higuchi's plots) of F1 to F9 formulations.Higuchi's plots for F1 to F9 formulations containing varying psyllium husk:HPMCK4M content; (—□—) F1, 50 mg:50 mg; (—Δ—) F2, 50 mg:75 mg; (—-—) F3, 50 mg:100 mg; (—◊—) F4, 75 mg:50 mg; (—×—) F5, 75 mg:75 mg; (—○—) F6, 75 mg:100 mg; (—*—) F7, 100 mg:50 mg; (—-—) F8, 100 mg:75 mg; (—+—) F9, 100 mg:100 mg. Each data point represents mean ±SD (n=3).


Design and optimization of floating drug delivery system of acyclovir.

Kharia AA, Hiremath SN, Singhai AK, Omray LK, Jain SK - Indian J Pharm Sci (2010)

Cumulative percent drug released Vs square root of time (Higuchi's plots) of F1 to F9 formulations.Higuchi's plots for F1 to F9 formulations containing varying psyllium husk:HPMCK4M content; (—□—) F1, 50 mg:50 mg; (—Δ—) F2, 50 mg:75 mg; (—-—) F3, 50 mg:100 mg; (—◊—) F4, 75 mg:50 mg; (—×—) F5, 75 mg:75 mg; (—○—) F6, 75 mg:100 mg; (—*—) F7, 100 mg:50 mg; (—-—) F8, 100 mg:75 mg; (—+—) F9, 100 mg:100 mg. Each data point represents mean ±SD (n=3).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3116305&req=5

Figure 2: Cumulative percent drug released Vs square root of time (Higuchi's plots) of F1 to F9 formulations.Higuchi's plots for F1 to F9 formulations containing varying psyllium husk:HPMCK4M content; (—□—) F1, 50 mg:50 mg; (—Δ—) F2, 50 mg:75 mg; (—-—) F3, 50 mg:100 mg; (—◊—) F4, 75 mg:50 mg; (—×—) F5, 75 mg:75 mg; (—○—) F6, 75 mg:100 mg; (—*—) F7, 100 mg:50 mg; (—-—) F8, 100 mg:75 mg; (—+—) F9, 100 mg:100 mg. Each data point represents mean ±SD (n=3).
Bottom Line: Validity of the developed polynomial equation was verified by designing two check point formulations (C1 and C2).The closeness of predicted and observed values for t(50%) and t(70%) indicates validity of derived equations for the dependent variables.The optimized formulations followed Higuchi's kinetics while the drug release mechanism was found to be anomalous type, controlled by diffusion through the swollen matrix.

View Article: PubMed Central - PubMed

Affiliation: Oriental College of Pharmacy, Raisen Road, Bhopal-462 021, India.

ABSTRACT
The purpose of the present work was to design and optimize floating drug delivery systems of acyclovir using psyllium husk and hydroxypropylmethylcellulose K4M as the polymers and sodium bicarbonate as a gas generating agent. The tablets were prepared by wet granulation method. A 3(2) full factorial design was used for optimization of drug release profile. The amount of psyllium husk (X1) and hydroxypropylmethylcellulose K4M (X2) were selected as independent variables. The times required for 50% (t(50%)) and 70% (t(70%)) drug dissolution were selected as dependent variables. All the designed nine batches of formulations were evaluated for hardness, friability, weight variation, drug content uniformity, swelling index, in vitro buoyancy, and in vitro drug release profile. All formulations had floating lag time below 3 min and constantly floated on dissolution medium for more than 24 h. Validity of the developed polynomial equation was verified by designing two check point formulations (C1 and C2). The closeness of predicted and observed values for t(50%) and t(70%) indicates validity of derived equations for the dependent variables. These studies indicated that the proper balance between psyllium husk and hydroxypropylmethylcellulose K4M can produce a drug dissolution profile similar to the predicted dissolution profile. The optimized formulations followed Higuchi's kinetics while the drug release mechanism was found to be anomalous type, controlled by diffusion through the swollen matrix.

No MeSH data available.


Related in: MedlinePlus