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Preparation and Characterization of Ethosomes for Topical delivery of Aceclofenac.

Barupal AK, Gupta V, Ramteke S - Indian J Pharm Sci (2010)

Bottom Line: Ethosomes of average size of 1.112 μm with a spherical shape bearing smooth surface were observed by transmission electron microscopy and surface electron microscopy.The maximum entrapment of ethosomes was 91.06±0.79%.Cumulative amount of drug permeated through the biological membrane was found to be in the range of 0.26±0.014 to 0.49±0.032 mg/cm(2).

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Sciences, Rajiv Gandhi Technical University, Airport Bypass Road, Gandhi Nagar, Bhopal-462 036, India.

ABSTRACT
The aim of present study was to prepare and characterized ethosomes of aceclofenac which may deliver the drug to targeted site more efficiently than marketed gel preparation and also overcome the problems related with oral administration of drug. The formulations were prepared with varying the quantity of ethanol 10-50% (v/v), lecithin 1-4% (w/v), propylene glycol 5-20% (v/v) and evaluated for their vesicle size, shape and surface morphology, entrapment efficiency and in vitro drug permeation study. Ethosomes of average size of 1.112 μm with a spherical shape bearing smooth surface were observed by transmission electron microscopy and surface electron microscopy. The maximum entrapment of ethosomes was 91.06±0.79%. Cumulative amount of drug permeated through the biological membrane was found to be in the range of 0.26±0.014 to 0.49±0.032 mg/cm(2). Stability profile of prepared system was assessed for 45 days and the results revealed that very less degradation of drug was observed during storage condition.

No MeSH data available.


Related in: MedlinePlus

Lecithin effect on in vitro drug permeation profileEffect of lecithin concentration on in vitro cumulative amount of drug permeation from various formulations ETL1 (—▲—), ETL2 (—♦—), ETL3 (—Δ—) and ETL4 (—■—)
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Figure 4: Lecithin effect on in vitro drug permeation profileEffect of lecithin concentration on in vitro cumulative amount of drug permeation from various formulations ETL1 (—▲—), ETL2 (—♦—), ETL3 (—Δ—) and ETL4 (—■—)

Mentions: As the lecithin is the main component of ethosomal system play important role in formulation. In present study the effect of lecithin concentration on drug permeation was also evaluated to optimize the formulation for sustained release properties on system. In prepared ethosomal system, as the concentration of lecithin increased above 2%, permeation of drug decreased from 0.42±0.022 mg/cm2 due to decrease in the bilayer deformability of vesicles (fig. 4).


Preparation and Characterization of Ethosomes for Topical delivery of Aceclofenac.

Barupal AK, Gupta V, Ramteke S - Indian J Pharm Sci (2010)

Lecithin effect on in vitro drug permeation profileEffect of lecithin concentration on in vitro cumulative amount of drug permeation from various formulations ETL1 (—▲—), ETL2 (—♦—), ETL3 (—Δ—) and ETL4 (—■—)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3116302&req=5

Figure 4: Lecithin effect on in vitro drug permeation profileEffect of lecithin concentration on in vitro cumulative amount of drug permeation from various formulations ETL1 (—▲—), ETL2 (—♦—), ETL3 (—Δ—) and ETL4 (—■—)
Mentions: As the lecithin is the main component of ethosomal system play important role in formulation. In present study the effect of lecithin concentration on drug permeation was also evaluated to optimize the formulation for sustained release properties on system. In prepared ethosomal system, as the concentration of lecithin increased above 2%, permeation of drug decreased from 0.42±0.022 mg/cm2 due to decrease in the bilayer deformability of vesicles (fig. 4).

Bottom Line: Ethosomes of average size of 1.112 μm with a spherical shape bearing smooth surface were observed by transmission electron microscopy and surface electron microscopy.The maximum entrapment of ethosomes was 91.06±0.79%.Cumulative amount of drug permeated through the biological membrane was found to be in the range of 0.26±0.014 to 0.49±0.032 mg/cm(2).

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Sciences, Rajiv Gandhi Technical University, Airport Bypass Road, Gandhi Nagar, Bhopal-462 036, India.

ABSTRACT
The aim of present study was to prepare and characterized ethosomes of aceclofenac which may deliver the drug to targeted site more efficiently than marketed gel preparation and also overcome the problems related with oral administration of drug. The formulations were prepared with varying the quantity of ethanol 10-50% (v/v), lecithin 1-4% (w/v), propylene glycol 5-20% (v/v) and evaluated for their vesicle size, shape and surface morphology, entrapment efficiency and in vitro drug permeation study. Ethosomes of average size of 1.112 μm with a spherical shape bearing smooth surface were observed by transmission electron microscopy and surface electron microscopy. The maximum entrapment of ethosomes was 91.06±0.79%. Cumulative amount of drug permeated through the biological membrane was found to be in the range of 0.26±0.014 to 0.49±0.032 mg/cm(2). Stability profile of prepared system was assessed for 45 days and the results revealed that very less degradation of drug was observed during storage condition.

No MeSH data available.


Related in: MedlinePlus