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Preparation and Characterization of Ethosomes for Topical delivery of Aceclofenac.

Barupal AK, Gupta V, Ramteke S - Indian J Pharm Sci (2010)

Bottom Line: Ethosomes of average size of 1.112 μm with a spherical shape bearing smooth surface were observed by transmission electron microscopy and surface electron microscopy.The maximum entrapment of ethosomes was 91.06±0.79%.Cumulative amount of drug permeated through the biological membrane was found to be in the range of 0.26±0.014 to 0.49±0.032 mg/cm(2).

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Sciences, Rajiv Gandhi Technical University, Airport Bypass Road, Gandhi Nagar, Bhopal-462 036, India.

ABSTRACT
The aim of present study was to prepare and characterized ethosomes of aceclofenac which may deliver the drug to targeted site more efficiently than marketed gel preparation and also overcome the problems related with oral administration of drug. The formulations were prepared with varying the quantity of ethanol 10-50% (v/v), lecithin 1-4% (w/v), propylene glycol 5-20% (v/v) and evaluated for their vesicle size, shape and surface morphology, entrapment efficiency and in vitro drug permeation study. Ethosomes of average size of 1.112 Ξm with a spherical shape bearing smooth surface were observed by transmission electron microscopy and surface electron microscopy. The maximum entrapment of ethosomes was 91.06¹0.79%. Cumulative amount of drug permeated through the biological membrane was found to be in the range of 0.26¹0.014 to 0.49¹0.032 mg/cm(2). Stability profile of prepared system was assessed for 45 days and the results revealed that very less degradation of drug was observed during storage condition.

No MeSH data available.


Related in: MedlinePlus

Ethanol effect on in vitro drug permeation profile Effect of ethanol concentration on in vitro cumulative drug permeation from various formulations, ETE1 (—â™Ķ—), ETE2 (—▩—), ETE3(—â–ē—), ETE4 (—○—) and ETE5 (—*—)
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Figure 3: Ethanol effect on in vitro drug permeation profile Effect of ethanol concentration on in vitro cumulative drug permeation from various formulations, ETE1 (—â™Ķ—), ETE2 (—▩—), ETE3(—â–ē—), ETE4 (—○—) and ETE5 (—*—)

Mentions: The effect of ethanol, lecithin and propylene glycol on drug permeation rate of aceclofenac was studied. On increasing the amount of ethanol from 10-0.30%, drug permeation was found to be increased where as further increase in ethanol concentration the drug permeation was found to be decreased which could be due to the disruption of bilayer vesicles at higher concentration of ethanol. The maximum permeation was found to be 0.41Âą0.080 mg/cm2at 30% ethanol concentration (fig. 3).


Preparation and Characterization of Ethosomes for Topical delivery of Aceclofenac.

Barupal AK, Gupta V, Ramteke S - Indian J Pharm Sci (2010)

Ethanol effect on in vitro drug permeation profile Effect of ethanol concentration on in vitro cumulative drug permeation from various formulations, ETE1 (—â™Ķ—), ETE2 (—▩—), ETE3(—â–ē—), ETE4 (—○—) and ETE5 (—*—)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3116302&req=5

Figure 3: Ethanol effect on in vitro drug permeation profile Effect of ethanol concentration on in vitro cumulative drug permeation from various formulations, ETE1 (—â™Ķ—), ETE2 (—▩—), ETE3(—â–ē—), ETE4 (—○—) and ETE5 (—*—)
Mentions: The effect of ethanol, lecithin and propylene glycol on drug permeation rate of aceclofenac was studied. On increasing the amount of ethanol from 10-0.30%, drug permeation was found to be increased where as further increase in ethanol concentration the drug permeation was found to be decreased which could be due to the disruption of bilayer vesicles at higher concentration of ethanol. The maximum permeation was found to be 0.41Âą0.080 mg/cm2at 30% ethanol concentration (fig. 3).

Bottom Line: Ethosomes of average size of 1.112 μm with a spherical shape bearing smooth surface were observed by transmission electron microscopy and surface electron microscopy.The maximum entrapment of ethosomes was 91.06±0.79%.Cumulative amount of drug permeated through the biological membrane was found to be in the range of 0.26±0.014 to 0.49±0.032 mg/cm(2).

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Sciences, Rajiv Gandhi Technical University, Airport Bypass Road, Gandhi Nagar, Bhopal-462 036, India.

ABSTRACT
The aim of present study was to prepare and characterized ethosomes of aceclofenac which may deliver the drug to targeted site more efficiently than marketed gel preparation and also overcome the problems related with oral administration of drug. The formulations were prepared with varying the quantity of ethanol 10-50% (v/v), lecithin 1-4% (w/v), propylene glycol 5-20% (v/v) and evaluated for their vesicle size, shape and surface morphology, entrapment efficiency and in vitro drug permeation study. Ethosomes of average size of 1.112 Ξm with a spherical shape bearing smooth surface were observed by transmission electron microscopy and surface electron microscopy. The maximum entrapment of ethosomes was 91.06¹0.79%. Cumulative amount of drug permeated through the biological membrane was found to be in the range of 0.26¹0.014 to 0.49¹0.032 mg/cm(2). Stability profile of prepared system was assessed for 45 days and the results revealed that very less degradation of drug was observed during storage condition.

No MeSH data available.


Related in: MedlinePlus