Limits...
Preparation and Characterization of Ethosomes for Topical delivery of Aceclofenac.

Barupal AK, Gupta V, Ramteke S - Indian J Pharm Sci (2010)

Bottom Line: Ethosomes of average size of 1.112 μm with a spherical shape bearing smooth surface were observed by transmission electron microscopy and surface electron microscopy.The maximum entrapment of ethosomes was 91.06±0.79%.Cumulative amount of drug permeated through the biological membrane was found to be in the range of 0.26±0.014 to 0.49±0.032 mg/cm(2).

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Sciences, Rajiv Gandhi Technical University, Airport Bypass Road, Gandhi Nagar, Bhopal-462 036, India.

ABSTRACT
The aim of present study was to prepare and characterized ethosomes of aceclofenac which may deliver the drug to targeted site more efficiently than marketed gel preparation and also overcome the problems related with oral administration of drug. The formulations were prepared with varying the quantity of ethanol 10-50% (v/v), lecithin 1-4% (w/v), propylene glycol 5-20% (v/v) and evaluated for their vesicle size, shape and surface morphology, entrapment efficiency and in vitro drug permeation study. Ethosomes of average size of 1.112 μm with a spherical shape bearing smooth surface were observed by transmission electron microscopy and surface electron microscopy. The maximum entrapment of ethosomes was 91.06±0.79%. Cumulative amount of drug permeated through the biological membrane was found to be in the range of 0.26±0.014 to 0.49±0.032 mg/cm(2). Stability profile of prepared system was assessed for 45 days and the results revealed that very less degradation of drug was observed during storage condition.

No MeSH data available.


Related in: MedlinePlus

Scanning electron microphotograph Visualization of ethosomes by scanning electron microscopy (bar 2 μm)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3116302&req=5

Figure 2: Scanning electron microphotograph Visualization of ethosomes by scanning electron microscopy (bar 2 μm)

Mentions: The average vesicle size of optimized formulations determined by Malvern Zetamaster was 1.112±0.053 μm. TEM photographs showed the surface morphology of the ethosomes as well as existence of unilamellar vesicular structure (fig. 1). The smooth surface of vesicles was confirmed by SEM (fig. 2).


Preparation and Characterization of Ethosomes for Topical delivery of Aceclofenac.

Barupal AK, Gupta V, Ramteke S - Indian J Pharm Sci (2010)

Scanning electron microphotograph Visualization of ethosomes by scanning electron microscopy (bar 2 μm)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3116302&req=5

Figure 2: Scanning electron microphotograph Visualization of ethosomes by scanning electron microscopy (bar 2 μm)
Mentions: The average vesicle size of optimized formulations determined by Malvern Zetamaster was 1.112±0.053 μm. TEM photographs showed the surface morphology of the ethosomes as well as existence of unilamellar vesicular structure (fig. 1). The smooth surface of vesicles was confirmed by SEM (fig. 2).

Bottom Line: Ethosomes of average size of 1.112 μm with a spherical shape bearing smooth surface were observed by transmission electron microscopy and surface electron microscopy.The maximum entrapment of ethosomes was 91.06±0.79%.Cumulative amount of drug permeated through the biological membrane was found to be in the range of 0.26±0.014 to 0.49±0.032 mg/cm(2).

View Article: PubMed Central - PubMed

Affiliation: School of Pharmaceutical Sciences, Rajiv Gandhi Technical University, Airport Bypass Road, Gandhi Nagar, Bhopal-462 036, India.

ABSTRACT
The aim of present study was to prepare and characterized ethosomes of aceclofenac which may deliver the drug to targeted site more efficiently than marketed gel preparation and also overcome the problems related with oral administration of drug. The formulations were prepared with varying the quantity of ethanol 10-50% (v/v), lecithin 1-4% (w/v), propylene glycol 5-20% (v/v) and evaluated for their vesicle size, shape and surface morphology, entrapment efficiency and in vitro drug permeation study. Ethosomes of average size of 1.112 μm with a spherical shape bearing smooth surface were observed by transmission electron microscopy and surface electron microscopy. The maximum entrapment of ethosomes was 91.06±0.79%. Cumulative amount of drug permeated through the biological membrane was found to be in the range of 0.26±0.014 to 0.49±0.032 mg/cm(2). Stability profile of prepared system was assessed for 45 days and the results revealed that very less degradation of drug was observed during storage condition.

No MeSH data available.


Related in: MedlinePlus