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Hepatoprotective Effect of Methanol Extracts of Zingiber officinale and Cichorium intybus.

Atta AH, Elkoly TA, Mouneir SM, Kamel G, Alwabel NA, Zaher S - Indian J Pharm Sci (2010)

Bottom Line: It also increased RBCs counts and Hb concentration, total or differential leucocytes counts.However it decreased platelet counts, platelet distribution width, mean platelet volume, platelet larger cell ratio.The hepatoprotective effect of ginger and chicory was also confirmed by the histopathological examination of liver tissue.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

ABSTRACT
The present work was carried out to investigate the hepatoprotective effect of ginger, chicory and their mixture against carbon tetrachloride intoxication in rats. Carbon tetrachloride treatment significantly elevated the alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma glutamyltransferase activities and the serum triglycerides and cholesterol concentration as compared to control group. It also increased RBCs counts and Hb concentration, total or differential leucocytes counts. However it decreased platelet counts, platelet distribution width, mean platelet volume, platelet larger cell ratio. Methanol extract of ginger (250 and 500 mg/kg) and chicory (250 and 500 mg/kg) given alone or mixed (1:1 wt/wt) significantly restored the carbon tetrachloride-induced alterations in the biochemical and cellular constituents of blood. No toxic symptoms were reported in doses up to 5 g/kg. Alkaloids and/or nitrogenous bases, carbohydrates and/or glycosides, tannins, flavonoids, saponins and unsaturated sterols and/or triterpenes are the main active constituents of their methanol extract. The hepatoprotective effect of ginger and chicory was also confirmed by the histopathological examination of liver tissue.

No MeSH data available.


Related in: MedlinePlus

Effect of methanol extracts of ginger and chicory on serum enzymes in rats with CCl4-induced hepatotoxicity.Effect of methanol extracts of ginger and chicory on serum enzymes in rats with CCl4-induced hepatotoxicity Different asterisks denote significant difference at P=0.05, n=6, values are mean±SD. ALT (), AST (), ALP () and GGT ()
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Figure 1: Effect of methanol extracts of ginger and chicory on serum enzymes in rats with CCl4-induced hepatotoxicity.Effect of methanol extracts of ginger and chicory on serum enzymes in rats with CCl4-induced hepatotoxicity Different asterisks denote significant difference at P=0.05, n=6, values are mean±SD. ALT (), AST (), ALP () and GGT ()

Mentions: The CCl4 intoxication significantly elevated the ALT, AST, ALP and GGT activity as compared to control group. Ginger methanol extract in small or large dose decreased only the activity of ALP and GGT, however it did not significantly affect the level of ALT or AST. Methanol extract of chicory in both doses and mixture of both chicory and ginger (1:1; w/w) significantly decreased serum ALT, AST and ALP. Oral administration of silymarine (25 mg/kg) did not significantly alter the elevated serum liver enzymatic activity (fig. 1.).


Hepatoprotective Effect of Methanol Extracts of Zingiber officinale and Cichorium intybus.

Atta AH, Elkoly TA, Mouneir SM, Kamel G, Alwabel NA, Zaher S - Indian J Pharm Sci (2010)

Effect of methanol extracts of ginger and chicory on serum enzymes in rats with CCl4-induced hepatotoxicity.Effect of methanol extracts of ginger and chicory on serum enzymes in rats with CCl4-induced hepatotoxicity Different asterisks denote significant difference at P=0.05, n=6, values are mean±SD. ALT (), AST (), ALP () and GGT ()
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3116299&req=5

Figure 1: Effect of methanol extracts of ginger and chicory on serum enzymes in rats with CCl4-induced hepatotoxicity.Effect of methanol extracts of ginger and chicory on serum enzymes in rats with CCl4-induced hepatotoxicity Different asterisks denote significant difference at P=0.05, n=6, values are mean±SD. ALT (), AST (), ALP () and GGT ()
Mentions: The CCl4 intoxication significantly elevated the ALT, AST, ALP and GGT activity as compared to control group. Ginger methanol extract in small or large dose decreased only the activity of ALP and GGT, however it did not significantly affect the level of ALT or AST. Methanol extract of chicory in both doses and mixture of both chicory and ginger (1:1; w/w) significantly decreased serum ALT, AST and ALP. Oral administration of silymarine (25 mg/kg) did not significantly alter the elevated serum liver enzymatic activity (fig. 1.).

Bottom Line: It also increased RBCs counts and Hb concentration, total or differential leucocytes counts.However it decreased platelet counts, platelet distribution width, mean platelet volume, platelet larger cell ratio.The hepatoprotective effect of ginger and chicory was also confirmed by the histopathological examination of liver tissue.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

ABSTRACT
The present work was carried out to investigate the hepatoprotective effect of ginger, chicory and their mixture against carbon tetrachloride intoxication in rats. Carbon tetrachloride treatment significantly elevated the alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma glutamyltransferase activities and the serum triglycerides and cholesterol concentration as compared to control group. It also increased RBCs counts and Hb concentration, total or differential leucocytes counts. However it decreased platelet counts, platelet distribution width, mean platelet volume, platelet larger cell ratio. Methanol extract of ginger (250 and 500 mg/kg) and chicory (250 and 500 mg/kg) given alone or mixed (1:1 wt/wt) significantly restored the carbon tetrachloride-induced alterations in the biochemical and cellular constituents of blood. No toxic symptoms were reported in doses up to 5 g/kg. Alkaloids and/or nitrogenous bases, carbohydrates and/or glycosides, tannins, flavonoids, saponins and unsaturated sterols and/or triterpenes are the main active constituents of their methanol extract. The hepatoprotective effect of ginger and chicory was also confirmed by the histopathological examination of liver tissue.

No MeSH data available.


Related in: MedlinePlus