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Microfluidic mixing: a review.

Lee CY, Chang CL, Wang YN, Fu LM - Int J Mol Sci (2011)

Bottom Line: In such devices, sample mixing is essentially achieved by enhancing the diffusion effect between the different species flows.Many mixers have been proposed to facilitate this task over the past 10 years.Accordingly, this paper commences by providing a high level overview of the field of microfluidic mixing devices before describing some of the more significant proposals for active and passive mixers.

View Article: PubMed Central - PubMed

Affiliation: Department of Materials Engineering, National Pingtung University of Science and Technology, Pingtung 912, Taiwan; E-Mail: leecy@mail.npust.edu.tw.

ABSTRACT
The aim of microfluidic mixing is to achieve a thorough and rapid mixing of multiple samples in microscale devices. In such devices, sample mixing is essentially achieved by enhancing the diffusion effect between the different species flows. Broadly speaking, microfluidic mixing schemes can be categorized as either "active", where an external energy force is applied to perturb the sample species, or "passive", where the contact area and contact time of the species samples are increased through specially-designed microchannel configurations. Many mixers have been proposed to facilitate this task over the past 10 years. Accordingly, this paper commences by providing a high level overview of the field of microfluidic mixing devices before describing some of the more significant proposals for active and passive mixers.

Show MeSH
Sequence of concentration distribution in confluent stream mixing [33].
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f4-ijms-12-03263: Sequence of concentration distribution in confluent stream mixing [33].

Mentions: Electrokinetic time-pulsed microfluidic mixers apply an electrokinetic driving force to transport the sample fluids while simultaneously inducing periodic perturbations (Figure 4) in the flow field [33]. The performance of electrokinetic time-pulsed microfluidic mixers can be enhanced in a number of ways, such as by increasing the contact area and contact time of the sample streams, or by creating irregular flow fields in the mixing channel. Several microchannel configurations have been proposed for increasing the contact area in such devices, including T-shaped, cross-shaped, double-cross-shaped, and multi-T-shaped configurations. Electrokinetic time-pulsed microfluidic mixers typically apply either square or sine wave driving signals with frequencies varying from 0.1–5 Hz. Chen et al. [4] proposed a microfluidic mixing scheme in which the streams of species were mixed via the application of chaotic electric fields to the four electrodes mounted on the upper and lower surfaces of the mixing chamber. Mixing efficiencies of up to 95% were achieved in the micromixer.


Microfluidic mixing: a review.

Lee CY, Chang CL, Wang YN, Fu LM - Int J Mol Sci (2011)

Sequence of concentration distribution in confluent stream mixing [33].
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3116190&req=5

f4-ijms-12-03263: Sequence of concentration distribution in confluent stream mixing [33].
Mentions: Electrokinetic time-pulsed microfluidic mixers apply an electrokinetic driving force to transport the sample fluids while simultaneously inducing periodic perturbations (Figure 4) in the flow field [33]. The performance of electrokinetic time-pulsed microfluidic mixers can be enhanced in a number of ways, such as by increasing the contact area and contact time of the sample streams, or by creating irregular flow fields in the mixing channel. Several microchannel configurations have been proposed for increasing the contact area in such devices, including T-shaped, cross-shaped, double-cross-shaped, and multi-T-shaped configurations. Electrokinetic time-pulsed microfluidic mixers typically apply either square or sine wave driving signals with frequencies varying from 0.1–5 Hz. Chen et al. [4] proposed a microfluidic mixing scheme in which the streams of species were mixed via the application of chaotic electric fields to the four electrodes mounted on the upper and lower surfaces of the mixing chamber. Mixing efficiencies of up to 95% were achieved in the micromixer.

Bottom Line: In such devices, sample mixing is essentially achieved by enhancing the diffusion effect between the different species flows.Many mixers have been proposed to facilitate this task over the past 10 years.Accordingly, this paper commences by providing a high level overview of the field of microfluidic mixing devices before describing some of the more significant proposals for active and passive mixers.

View Article: PubMed Central - PubMed

Affiliation: Department of Materials Engineering, National Pingtung University of Science and Technology, Pingtung 912, Taiwan; E-Mail: leecy@mail.npust.edu.tw.

ABSTRACT
The aim of microfluidic mixing is to achieve a thorough and rapid mixing of multiple samples in microscale devices. In such devices, sample mixing is essentially achieved by enhancing the diffusion effect between the different species flows. Broadly speaking, microfluidic mixing schemes can be categorized as either "active", where an external energy force is applied to perturb the sample species, or "passive", where the contact area and contact time of the species samples are increased through specially-designed microchannel configurations. Many mixers have been proposed to facilitate this task over the past 10 years. Accordingly, this paper commences by providing a high level overview of the field of microfluidic mixing devices before describing some of the more significant proposals for active and passive mixers.

Show MeSH