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Antioxidant properties of aminoethylcysteine ketimine decarboxylated dimer: a review.

Macone A, Fontana M, Barba M, Botta B, Nardini M, Ghirga F, Calcaterra A, Pecci L, Matarese RM - Int J Mol Sci (2011)

Bottom Line: Attention has been focused on its antioxidant properties and on its reactivity against oxygen and nitrogen reactive species.All these studies report that aminoethylcysteine ketimine decarboxylated dimer is able to interact both with reactive oxygen and nitrogen species (hydrogen peroxide, superoxide anion, hydroxyl radical, peroxynitrite and its derivatives).Its antioxidant activity is similar to that of Vitamin E while higher than other hydrophilic antioxidants, such as trolox and N-acetylcysteine.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemical Sciences, Sapienza, University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy; E-Mails: alberto.macone@uniroma1.it (A.M.); mario.fontana@uniroma1.it (M.F.); laura.pecci@uniroma1.it (L.P.).

ABSTRACT
Aminoethylcysteine ketimine decarboxylated dimer is a natural sulfur-containing compound detected in human plasma and urine, in mammalian brain and in many common edible vegetables. Over the past decade many studies have been undertaken to identify its metabolic role. Attention has been focused on its antioxidant properties and on its reactivity against oxygen and nitrogen reactive species. These properties have been studied in different model systems starting from plasma lipoproteins to specific cellular lines. All these studies report that aminoethylcysteine ketimine decarboxylated dimer is able to interact both with reactive oxygen and nitrogen species (hydrogen peroxide, superoxide anion, hydroxyl radical, peroxynitrite and its derivatives). Its antioxidant activity is similar to that of Vitamin E while higher than other hydrophilic antioxidants, such as trolox and N-acetylcysteine.

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Aminoethylcysteine ketimine decarboxylated dimer.
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f1-ijms-12-03072: Aminoethylcysteine ketimine decarboxylated dimer.

Mentions: In recent years, increasing attention has been focused on the discovery of new physiological sulfur compounds that show antioxidant activities. Among these, a very interesting one is aminoethylcysteine ketimine decarboxylated dimer (Figure 1), which is a member of a group of eterocyclic ketimines containing sulfur and nitrogen arising from the metabolism of l-cystathionine, l-lanthionine and (S)-2-aminoethyl-l-cysteine [16]. Many of these ketimines and their derivatives have been found in detectable amounts in mammalian tissues and fluids [17–24].


Antioxidant properties of aminoethylcysteine ketimine decarboxylated dimer: a review.

Macone A, Fontana M, Barba M, Botta B, Nardini M, Ghirga F, Calcaterra A, Pecci L, Matarese RM - Int J Mol Sci (2011)

Aminoethylcysteine ketimine decarboxylated dimer.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3116176&req=5

f1-ijms-12-03072: Aminoethylcysteine ketimine decarboxylated dimer.
Mentions: In recent years, increasing attention has been focused on the discovery of new physiological sulfur compounds that show antioxidant activities. Among these, a very interesting one is aminoethylcysteine ketimine decarboxylated dimer (Figure 1), which is a member of a group of eterocyclic ketimines containing sulfur and nitrogen arising from the metabolism of l-cystathionine, l-lanthionine and (S)-2-aminoethyl-l-cysteine [16]. Many of these ketimines and their derivatives have been found in detectable amounts in mammalian tissues and fluids [17–24].

Bottom Line: Attention has been focused on its antioxidant properties and on its reactivity against oxygen and nitrogen reactive species.All these studies report that aminoethylcysteine ketimine decarboxylated dimer is able to interact both with reactive oxygen and nitrogen species (hydrogen peroxide, superoxide anion, hydroxyl radical, peroxynitrite and its derivatives).Its antioxidant activity is similar to that of Vitamin E while higher than other hydrophilic antioxidants, such as trolox and N-acetylcysteine.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemical Sciences, Sapienza, University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy; E-Mails: alberto.macone@uniroma1.it (A.M.); mario.fontana@uniroma1.it (M.F.); laura.pecci@uniroma1.it (L.P.).

ABSTRACT
Aminoethylcysteine ketimine decarboxylated dimer is a natural sulfur-containing compound detected in human plasma and urine, in mammalian brain and in many common edible vegetables. Over the past decade many studies have been undertaken to identify its metabolic role. Attention has been focused on its antioxidant properties and on its reactivity against oxygen and nitrogen reactive species. These properties have been studied in different model systems starting from plasma lipoproteins to specific cellular lines. All these studies report that aminoethylcysteine ketimine decarboxylated dimer is able to interact both with reactive oxygen and nitrogen species (hydrogen peroxide, superoxide anion, hydroxyl radical, peroxynitrite and its derivatives). Its antioxidant activity is similar to that of Vitamin E while higher than other hydrophilic antioxidants, such as trolox and N-acetylcysteine.

Show MeSH