Limits...
Effect of a dual drug-coated stent with abciximab and alpha-lipoic Acid in a porcine coronary restenosis model.

Lim KS, Hong YJ, Hachinohe D, Ahmed K, Jeong MH, Kim JH, Sim DS, Lee MG, Park KH, Kim JH, Ahn Y, Cho JG, Park JC, Song SJ, Jung KW, Cho DL, Kang JC - Korean Circ J (2011)

Bottom Line: There was no significant difference in the injury score between the two groups.In the neointima, the lymphohistiocyte count was significantly lower in dual-coat stent group compared with the control stent group (120±85 cells vs. 159±80 cells, p=0.048).Although the dual-coated stent with abciximab and ALA showed no significant difference in inhibition of neointimal hyperplasia when compared with the bare metal stent, it was associated with a reduced inflammatory reaction when compared with the control stent in a porcine coronary restenosis model.

View Article: PubMed Central - PubMed

Affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health and Welfare, Gwangju, Korea.

ABSTRACT

Background and objectives: The aim of this study was to examine the anti-proliferative and anti-inflammatory effects of a stent coated with abciximab and alpha-lipoic acid (ALA) in a porcine coronary overstretch restenosis model.

Materials and methods: A total of 10 pigs were randomized into two groups (10 pigs, 10 coronaries in each group) in which the coronary arteries were stented with a dual-coated stent and a bare metal stent (control) by randomization. Stents were deployed with oversizing (stent/artery ratio 1.3 : 1) in the porcine coronary arteries, and histopathology was assessed 28 days after stenting.

Results: There was no significant difference in the injury score between the two groups. In the neointima, the lymphohistiocyte count was significantly lower in dual-coat stent group compared with the control stent group (120±85 cells vs. 159±80 cells, p=0.048). There was no significant difference in the fibrin score between the two groups (0.16±0.34 in the dual-coated stent group vs. 0.25±0.48 in the control stent group, p=0.446). The neointima area was not significantly different between both groups (1.55±0.8 mm(2) in dual-coated stent group vs. 1.40±0.86 mm(2) in the control stent group, p=0.447).

Conclusion: Although the dual-coated stent with abciximab and ALA showed no significant difference in inhibition of neointimal hyperplasia when compared with the bare metal stent, it was associated with a reduced inflammatory reaction when compared with the control stent in a porcine coronary restenosis model.

No MeSH data available.


Related in: MedlinePlus

Correlations between the lymphohistiocyte count and neointimal hyperplasia area (A) and percent area stenosis (B).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3116101&req=5

Figure 4: Correlations between the lymphohistiocyte count and neointimal hyperplasia area (A) and percent area stenosis (B).

Mentions: Significant correlations were found between the lymphohistiocyte count and the neointimal hyperplasia area (r=0.567, p<0.001) and between the lymphohitiocyte count and the percent area stenosis (r=0.476, p<0.001) (Fig. 4). There was no significant difference in the injury score between the two groups (1.44±0.59 in the dual-coated stent group vs. 1.33±0.66 in the control stent group, p=0.522), nor in the neointima area (1.55±0.82 mm2 in the dual-coated stent group vs. 1.40±0.86 mm2 in the control stent group, p=0.447) (Table 1). In the neointima, the lymphohistiocyte count was significantly lower in the dual-coated stent group compared with the control stent group (120±85 cells vs. 159±80 cells, p=0.048) (Fig. 5). There was no significant difference in the fibrin score between the two groups (0.16±0.34 in dual-coated stent group vs. 0.25±0.48 in the control stent group, p=0.446) (Fig. 3).


Effect of a dual drug-coated stent with abciximab and alpha-lipoic Acid in a porcine coronary restenosis model.

Lim KS, Hong YJ, Hachinohe D, Ahmed K, Jeong MH, Kim JH, Sim DS, Lee MG, Park KH, Kim JH, Ahn Y, Cho JG, Park JC, Song SJ, Jung KW, Cho DL, Kang JC - Korean Circ J (2011)

Correlations between the lymphohistiocyte count and neointimal hyperplasia area (A) and percent area stenosis (B).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3116101&req=5

Figure 4: Correlations between the lymphohistiocyte count and neointimal hyperplasia area (A) and percent area stenosis (B).
Mentions: Significant correlations were found between the lymphohistiocyte count and the neointimal hyperplasia area (r=0.567, p<0.001) and between the lymphohitiocyte count and the percent area stenosis (r=0.476, p<0.001) (Fig. 4). There was no significant difference in the injury score between the two groups (1.44±0.59 in the dual-coated stent group vs. 1.33±0.66 in the control stent group, p=0.522), nor in the neointima area (1.55±0.82 mm2 in the dual-coated stent group vs. 1.40±0.86 mm2 in the control stent group, p=0.447) (Table 1). In the neointima, the lymphohistiocyte count was significantly lower in the dual-coated stent group compared with the control stent group (120±85 cells vs. 159±80 cells, p=0.048) (Fig. 5). There was no significant difference in the fibrin score between the two groups (0.16±0.34 in dual-coated stent group vs. 0.25±0.48 in the control stent group, p=0.446) (Fig. 3).

Bottom Line: There was no significant difference in the injury score between the two groups.In the neointima, the lymphohistiocyte count was significantly lower in dual-coat stent group compared with the control stent group (120±85 cells vs. 159±80 cells, p=0.048).Although the dual-coated stent with abciximab and ALA showed no significant difference in inhibition of neointimal hyperplasia when compared with the bare metal stent, it was associated with a reduced inflammatory reaction when compared with the control stent in a porcine coronary restenosis model.

View Article: PubMed Central - PubMed

Affiliation: The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health and Welfare, Gwangju, Korea.

ABSTRACT

Background and objectives: The aim of this study was to examine the anti-proliferative and anti-inflammatory effects of a stent coated with abciximab and alpha-lipoic acid (ALA) in a porcine coronary overstretch restenosis model.

Materials and methods: A total of 10 pigs were randomized into two groups (10 pigs, 10 coronaries in each group) in which the coronary arteries were stented with a dual-coated stent and a bare metal stent (control) by randomization. Stents were deployed with oversizing (stent/artery ratio 1.3 : 1) in the porcine coronary arteries, and histopathology was assessed 28 days after stenting.

Results: There was no significant difference in the injury score between the two groups. In the neointima, the lymphohistiocyte count was significantly lower in dual-coat stent group compared with the control stent group (120±85 cells vs. 159±80 cells, p=0.048). There was no significant difference in the fibrin score between the two groups (0.16±0.34 in the dual-coated stent group vs. 0.25±0.48 in the control stent group, p=0.446). The neointima area was not significantly different between both groups (1.55±0.8 mm(2) in dual-coated stent group vs. 1.40±0.86 mm(2) in the control stent group, p=0.447).

Conclusion: Although the dual-coated stent with abciximab and ALA showed no significant difference in inhibition of neointimal hyperplasia when compared with the bare metal stent, it was associated with a reduced inflammatory reaction when compared with the control stent in a porcine coronary restenosis model.

No MeSH data available.


Related in: MedlinePlus