Limits...
The relationship between ambulatory arterial stiffness index and blood pressure variability in hypertensive patients.

Lee HT, Lim YH, Kim BK, Lee KW, Lee JU, Kim KS, Kim SG, Kim JH, Lim HK, Shin J, Kim YM - Korean Circ J (2011)

Bottom Line: AASI had a simple correlation with age (R=0.189, p<0.001), relative wall thickness (RWT) (R=0.115, p=0.019), left ventricular mass index (LVMI) (R=0.192, p<0.001), average systolic BP (SBP) (R=0.232, p<0.001), average pulse pressure (PP) (R=0.363, p<0.001), SD of diastolic BP (DBP) (R=-0.352, p<0.001), SD of PP (R=0.330, p<0.001), SD of heart rate (HR) (R=-0.268, p<0.001), and nocturnal dipping (R=-0.137, p=0.005).In multiple linear regression analysis model including clinical parameters and 24 hour-ABPM parameters, independent predictors of AASI were SD of PP (β=1.246, p<0.001), SD of DBP (β=-1.067, p<0.001), SD of SBP (β=-0.197, p<0.001), and non-dipper (β=0.054, p=0.033).AASI is closely correlated with BP variability.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.

ABSTRACT

Background and objectives: Ambulatory arterial stiffness index (AASI) is well known as a predictor of cardiovascular mortality in hypertensive patients. Mathematically, AASI reflect the standard deviation (SD) of blood pressure (BP) variation. AASI is measured higher levels in non-dipper than dipper. Thus, AASI has a possibility of not only reflecting arterial stiffness but also BP variability and/or autonomic nervous dysfunction.

Subjects and methods: Consecutive data from 418 untreated hypertensive patients were analyzed retrospectively. We examined the association between the 24-hour ambulatory BP monitoring (ABPM) parameters and AASI.

Results: AASI had a simple correlation with age (R=0.189, p<0.001), relative wall thickness (RWT) (R=0.115, p=0.019), left ventricular mass index (LVMI) (R=0.192, p<0.001), average systolic BP (SBP) (R=0.232, p<0.001), average pulse pressure (PP) (R=0.363, p<0.001), SD of diastolic BP (DBP) (R=-0.352, p<0.001), SD of PP (R=0.330, p<0.001), SD of heart rate (HR) (R=-0.268, p<0.001), and nocturnal dipping (R=-0.137, p=0.005). In multiple linear regression analysis model including clinical parameters and 24 hour-ABPM parameters, independent predictors of AASI were SD of PP (β=1.246, p<0.001), SD of DBP (β=-1.067, p<0.001), SD of SBP (β=-0.197, p<0.001), and non-dipper (β=0.054, p=0.033).

Conclusion: AASI is closely correlated with BP variability. The result of this study shows that AASI is not only a parameter for arterial stiffness, but also a parameter for BP variability.

No MeSH data available.


Related in: MedlinePlus

Correlation of ambulatory arterial stiffness index with nocturnal dipping.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3116100&req=5

Figure 2: Correlation of ambulatory arterial stiffness index with nocturnal dipping.

Mentions: AASI was significantly higher in non-dippers than in dippers (0.602±0.133 vs. 0.552±0.128; p<0.001). Bivariate correlations of AASI with 24 hour ABPM variables are listed in Table 4. AASI had significant correlation with average SBP (R=0.232, p<0.001), average PP (R=0.363, p<0.001), SD of DBP (R=-0.352, p<0.001), SD of PP (R=0.330, p<0.001), SD of HR (R=-0.268, p<0.001), CV for SBP (R=-0.135, p=0.006), CV for DBP (R=-0.318, p<0.001), and nocturnal dipping (R=-0.137, p=0.005) (Fig. 2).


The relationship between ambulatory arterial stiffness index and blood pressure variability in hypertensive patients.

Lee HT, Lim YH, Kim BK, Lee KW, Lee JU, Kim KS, Kim SG, Kim JH, Lim HK, Shin J, Kim YM - Korean Circ J (2011)

Correlation of ambulatory arterial stiffness index with nocturnal dipping.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3116100&req=5

Figure 2: Correlation of ambulatory arterial stiffness index with nocturnal dipping.
Mentions: AASI was significantly higher in non-dippers than in dippers (0.602±0.133 vs. 0.552±0.128; p<0.001). Bivariate correlations of AASI with 24 hour ABPM variables are listed in Table 4. AASI had significant correlation with average SBP (R=0.232, p<0.001), average PP (R=0.363, p<0.001), SD of DBP (R=-0.352, p<0.001), SD of PP (R=0.330, p<0.001), SD of HR (R=-0.268, p<0.001), CV for SBP (R=-0.135, p=0.006), CV for DBP (R=-0.318, p<0.001), and nocturnal dipping (R=-0.137, p=0.005) (Fig. 2).

Bottom Line: AASI had a simple correlation with age (R=0.189, p<0.001), relative wall thickness (RWT) (R=0.115, p=0.019), left ventricular mass index (LVMI) (R=0.192, p<0.001), average systolic BP (SBP) (R=0.232, p<0.001), average pulse pressure (PP) (R=0.363, p<0.001), SD of diastolic BP (DBP) (R=-0.352, p<0.001), SD of PP (R=0.330, p<0.001), SD of heart rate (HR) (R=-0.268, p<0.001), and nocturnal dipping (R=-0.137, p=0.005).In multiple linear regression analysis model including clinical parameters and 24 hour-ABPM parameters, independent predictors of AASI were SD of PP (β=1.246, p<0.001), SD of DBP (β=-1.067, p<0.001), SD of SBP (β=-0.197, p<0.001), and non-dipper (β=0.054, p=0.033).AASI is closely correlated with BP variability.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.

ABSTRACT

Background and objectives: Ambulatory arterial stiffness index (AASI) is well known as a predictor of cardiovascular mortality in hypertensive patients. Mathematically, AASI reflect the standard deviation (SD) of blood pressure (BP) variation. AASI is measured higher levels in non-dipper than dipper. Thus, AASI has a possibility of not only reflecting arterial stiffness but also BP variability and/or autonomic nervous dysfunction.

Subjects and methods: Consecutive data from 418 untreated hypertensive patients were analyzed retrospectively. We examined the association between the 24-hour ambulatory BP monitoring (ABPM) parameters and AASI.

Results: AASI had a simple correlation with age (R=0.189, p<0.001), relative wall thickness (RWT) (R=0.115, p=0.019), left ventricular mass index (LVMI) (R=0.192, p<0.001), average systolic BP (SBP) (R=0.232, p<0.001), average pulse pressure (PP) (R=0.363, p<0.001), SD of diastolic BP (DBP) (R=-0.352, p<0.001), SD of PP (R=0.330, p<0.001), SD of heart rate (HR) (R=-0.268, p<0.001), and nocturnal dipping (R=-0.137, p=0.005). In multiple linear regression analysis model including clinical parameters and 24 hour-ABPM parameters, independent predictors of AASI were SD of PP (β=1.246, p<0.001), SD of DBP (β=-1.067, p<0.001), SD of SBP (β=-0.197, p<0.001), and non-dipper (β=0.054, p=0.033).

Conclusion: AASI is closely correlated with BP variability. The result of this study shows that AASI is not only a parameter for arterial stiffness, but also a parameter for BP variability.

No MeSH data available.


Related in: MedlinePlus