Limits...
Ultrasonographic findings in a cow with abomasal lymphosarcoma: case report.

Braun U, Schnetzler C, Dettwiler M, Sydler T, Meyer S, Gerspach C - BMC Vet. Res. (2011)

Bottom Line: The results of serum biochemistry and rumen fluid analysis were indicative of abomasal reflux syndrome.The main ultrasonographic findings were two enlarged lymph nodes caudal to the reticulum and a severely enlarged abomasum with thickening of the abomasal wall and folds.This is an interesting case, which broadens the spectrum of abomasal reflux syndrome.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Farm Animals, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland. ubraun@vetclinics.uzh.ch

ABSTRACT

Background: This case report describes the clinical and ultrasonographic findings in a Swiss Braunvieh cow with lymphosarcoma of the abomasum.

Case presentation: The main clinical findings were vomiting in response to eating and melena. The results of serum biochemistry and rumen fluid analysis were indicative of abomasal reflux syndrome. The main ultrasonographic findings were two enlarged lymph nodes caudal to the reticulum and a severely enlarged abomasum with thickening of the abomasal wall and folds. Based on all the findings, pyloric stenosis caused by lymphosarcoma was tentatively diagnosed and later confirmed at postmortem examination.

Conclusions: This is an interesting case, which broadens the spectrum of abomasal reflux syndrome.

Show MeSH

Related in: MedlinePlus

Postmortem specimen of the pylorus. Postmortem specimen of the pylorus showing a severely thickened mucous membrane in a Swiss Braunvieh cow with lymphosarcoma of the abomasum.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3113951&req=5

Figure 4: Postmortem specimen of the pylorus. Postmortem specimen of the pylorus showing a severely thickened mucous membrane in a Swiss Braunvieh cow with lymphosarcoma of the abomasum.

Mentions: The clinical findings were suggestive of pyloric stenosis causing vomiting. Based on previous experience involving a cow with similar ultrasonographic findings (enlarged lymph nodes caudal to reticulum, thickened abomasal wall and folds) a tentative diagnosis of lymphosarcoma of the abomasum was made. The cow was euthanased because of a grave prognosis, and necropsied. The rumen was severely distended with liquid contents. The abomasum was 107 cm long and dilated, and the mucosa had multiple superficial ulcers. The wall of the abomasum and pylorus was severely thickened and very firm (Figures 3 and 4). The omasum was also dilated and its serosa had nodular lesions. Several gastrointestinal lymph nodes and those of the lungs and spleen were greatly enlarged, as were the two lymph nodes seen during ultrasonography (Figure 5). The tentative diagnosis of lymphosarcoma was confirmed via histological examination of the abomasum, omasum and various lymph nodes. There was infiltration of all layers of the abomasal wall (tunica mucosa, submucosa and muscularis), the serosa of the omasum and the enlarged lymph nodes with a homogeneous population of round lymphoblasts, which were 10 to 15 μm in diameter and had little cytoplasm and a round to oval nucleus (Figure 6). The chromatin of the nuclei was vesicular and nucleoli occurred sporadically. There were moderate numbers of mitotic figures, some of which were atypical. The tumour cells were surrounded by a sparse fibrovascular stroma. Immunohistochemical testing showed that the lymphoblasts were CD3-positive (and CD79a-negative) und thus were derived from T-lymphocytes. This clearly excludes false negativ ELISA since BLV causes B-cell lymphoma.


Ultrasonographic findings in a cow with abomasal lymphosarcoma: case report.

Braun U, Schnetzler C, Dettwiler M, Sydler T, Meyer S, Gerspach C - BMC Vet. Res. (2011)

Postmortem specimen of the pylorus. Postmortem specimen of the pylorus showing a severely thickened mucous membrane in a Swiss Braunvieh cow with lymphosarcoma of the abomasum.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3113951&req=5

Figure 4: Postmortem specimen of the pylorus. Postmortem specimen of the pylorus showing a severely thickened mucous membrane in a Swiss Braunvieh cow with lymphosarcoma of the abomasum.
Mentions: The clinical findings were suggestive of pyloric stenosis causing vomiting. Based on previous experience involving a cow with similar ultrasonographic findings (enlarged lymph nodes caudal to reticulum, thickened abomasal wall and folds) a tentative diagnosis of lymphosarcoma of the abomasum was made. The cow was euthanased because of a grave prognosis, and necropsied. The rumen was severely distended with liquid contents. The abomasum was 107 cm long and dilated, and the mucosa had multiple superficial ulcers. The wall of the abomasum and pylorus was severely thickened and very firm (Figures 3 and 4). The omasum was also dilated and its serosa had nodular lesions. Several gastrointestinal lymph nodes and those of the lungs and spleen were greatly enlarged, as were the two lymph nodes seen during ultrasonography (Figure 5). The tentative diagnosis of lymphosarcoma was confirmed via histological examination of the abomasum, omasum and various lymph nodes. There was infiltration of all layers of the abomasal wall (tunica mucosa, submucosa and muscularis), the serosa of the omasum and the enlarged lymph nodes with a homogeneous population of round lymphoblasts, which were 10 to 15 μm in diameter and had little cytoplasm and a round to oval nucleus (Figure 6). The chromatin of the nuclei was vesicular and nucleoli occurred sporadically. There were moderate numbers of mitotic figures, some of which were atypical. The tumour cells were surrounded by a sparse fibrovascular stroma. Immunohistochemical testing showed that the lymphoblasts were CD3-positive (and CD79a-negative) und thus were derived from T-lymphocytes. This clearly excludes false negativ ELISA since BLV causes B-cell lymphoma.

Bottom Line: The results of serum biochemistry and rumen fluid analysis were indicative of abomasal reflux syndrome.The main ultrasonographic findings were two enlarged lymph nodes caudal to the reticulum and a severely enlarged abomasum with thickening of the abomasal wall and folds.This is an interesting case, which broadens the spectrum of abomasal reflux syndrome.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Farm Animals, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland. ubraun@vetclinics.uzh.ch

ABSTRACT

Background: This case report describes the clinical and ultrasonographic findings in a Swiss Braunvieh cow with lymphosarcoma of the abomasum.

Case presentation: The main clinical findings were vomiting in response to eating and melena. The results of serum biochemistry and rumen fluid analysis were indicative of abomasal reflux syndrome. The main ultrasonographic findings were two enlarged lymph nodes caudal to the reticulum and a severely enlarged abomasum with thickening of the abomasal wall and folds. Based on all the findings, pyloric stenosis caused by lymphosarcoma was tentatively diagnosed and later confirmed at postmortem examination.

Conclusions: This is an interesting case, which broadens the spectrum of abomasal reflux syndrome.

Show MeSH
Related in: MedlinePlus