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Granulomatous meningoencephalomyelitis in dogs: A review.

O'Neill EJ, Merrett D, Jones B - Ir Vet J (2005)

Bottom Line: The aetiology of the disease remains unknown, although an immune-mediated cause is suspected.This article reviewed the typical history, clinical signs and pathology of the condition along with current opinions on pathogenesis.The potential differential diagnoses for the disease were discussed along with current treatment options.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Small Animal Clinical Studies, Faculty of Veterinary Medicine, University College Dublin, Ireland. emma.oneill@ucd.ie.

ABSTRACT
: Granulomatous meningoencephalomyelitis (GME) is an inflammatory disease of the central nervous system in dogs that is characterised by focal or disseminated granulomatous lesions within the brain and/or spinal cord, non-suppurative meningitis and perivascular mononuclear cuffing. The aetiology of the disease remains unknown, although an immune-mediated cause is suspected. This article reviewed the typical history, clinical signs and pathology of the condition along with current opinions on pathogenesis. The potential differential diagnoses for the disease were discussed along with current treatment options.

No MeSH data available.


Related in: MedlinePlus

Cerebrospinal fluid cytology demonstrating mononuclear cell pleocytosis in a case of GME. Original magnification ×40.
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Figure 2: Cerebrospinal fluid cytology demonstrating mononuclear cell pleocytosis in a case of GME. Original magnification ×40.

Mentions: Routine screening blood tests are often unrewarding for making a diagnosis of GME [7]. In some cases mild to moderate leukocytosis is observed [31,40], although frequently the rise is within the range encountered with 'stress' responses [31] and elevations are not seen in the majority of cases [40]. Whilst CSF analysis is the mainstay of diagnosis [3], considerable variation in the findings may be encountered. Table 4 shows the classical features of GME and variations that may be expected. Figure 2 shows CSF cytology from a GME case.


Granulomatous meningoencephalomyelitis in dogs: A review.

O'Neill EJ, Merrett D, Jones B - Ir Vet J (2005)

Cerebrospinal fluid cytology demonstrating mononuclear cell pleocytosis in a case of GME. Original magnification ×40.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3113901&req=5

Figure 2: Cerebrospinal fluid cytology demonstrating mononuclear cell pleocytosis in a case of GME. Original magnification ×40.
Mentions: Routine screening blood tests are often unrewarding for making a diagnosis of GME [7]. In some cases mild to moderate leukocytosis is observed [31,40], although frequently the rise is within the range encountered with 'stress' responses [31] and elevations are not seen in the majority of cases [40]. Whilst CSF analysis is the mainstay of diagnosis [3], considerable variation in the findings may be encountered. Table 4 shows the classical features of GME and variations that may be expected. Figure 2 shows CSF cytology from a GME case.

Bottom Line: The aetiology of the disease remains unknown, although an immune-mediated cause is suspected.This article reviewed the typical history, clinical signs and pathology of the condition along with current opinions on pathogenesis.The potential differential diagnoses for the disease were discussed along with current treatment options.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Small Animal Clinical Studies, Faculty of Veterinary Medicine, University College Dublin, Ireland. emma.oneill@ucd.ie.

ABSTRACT
: Granulomatous meningoencephalomyelitis (GME) is an inflammatory disease of the central nervous system in dogs that is characterised by focal or disseminated granulomatous lesions within the brain and/or spinal cord, non-suppurative meningitis and perivascular mononuclear cuffing. The aetiology of the disease remains unknown, although an immune-mediated cause is suspected. This article reviewed the typical history, clinical signs and pathology of the condition along with current opinions on pathogenesis. The potential differential diagnoses for the disease were discussed along with current treatment options.

No MeSH data available.


Related in: MedlinePlus