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Immune-mediated thrombocytopenia associated with angiostrongylus vasorum infection in a Jack Russell terrier.

Jo'neill E, Acke E, Tobin E, McCarthy G - Ir Vet J (2010)

Bottom Line: Haematology confirmed a platelet count of 1.0 × 10/L.Initially anaemia developed following gastrointestinal haemorrhage; however, after symptomatic treatment the dog showed a marked clinical improvement.The dog made a full clinical recovery with all treatment was withdrawn within five weeks of diagnosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: School of Agriculture, Food Sciences and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland. emma.oneill@ucd.ie.

ABSTRACT
A twenty-month-old Jack Russell terrier was presented with a four-day history of thrombocytopenia, echymotic inguinal haemorrhages, coughing and reduced exercise tolerance. Clinical examination revealed several petechial haemorrhages on the gingivae and small echymotic haemorrhages in the inguinal region, along with mild bilateral epistaxis. Haematology confirmed a platelet count of 1.0 × 10/L. Thoracic radiographs revealed a wide-spread mixed alveolar-interstitial lung pattern, apparent throughout the entire lungfield, but particularly marked within the left lung lobes. A presumptive diagnosis of immune-mediated thrombocytopenia was made and the dog was treated with vincristine and immunosuppressive doses of prednisolone. Initially anaemia developed following gastrointestinal haemorrhage; however, after symptomatic treatment the dog showed a marked clinical improvement. Evaluation for an underlying cause of the disease revealed Angiostrongylus vasorum L1 larvae on faecal analysis and treatment with fenbendazole was commenced. The dog made a full clinical recovery with all treatment was withdrawn within five weeks of diagnosis. This is the second report of immune-mediated thrombocytopenia associated with Angiostrongylus vasorum infection and it is the first to be successfully managed. The report highlights that Angiostrongylus vasorum should be considered in young dogs presented with thrombocytopenia.

No MeSH data available.


Related in: MedlinePlus

Right lateral (A) and dorsoventral (B) thoracic radiographs taken on the day of referral (day four), showing a widespread mixed alveolar-interstitial lung pattern. This is visible throughout the lungfield, but is particularly marked within the left lung lobes. Pleural fissure lines are visible between both the right middle and right caudal lobes and the accessory and left caudal lung lobes, however a significant pleural effusion is not discernable.
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Figure 1: Right lateral (A) and dorsoventral (B) thoracic radiographs taken on the day of referral (day four), showing a widespread mixed alveolar-interstitial lung pattern. This is visible throughout the lungfield, but is particularly marked within the left lung lobes. Pleural fissure lines are visible between both the right middle and right caudal lobes and the accessory and left caudal lung lobes, however a significant pleural effusion is not discernable.

Mentions: Haematology at the time of referral (day four) demonstrated severe thrombocytopenia (1.0 × 109/L machine count, confirmed as accurate on examination of a smear) accompanied by a mild, regenerative anaemia (PCV 0.27 L/L). Serum biochemistry demonstrated mild hyperglobulinaemia (45.7 g/L) and mild elevation of serum alkaline phosphatase (103 U/L). Thoracic radiography (Figure 1) revealed a widespread mixed alveolar-interstitial lung pattern. This was apparent throughout the lungfield, but was particularly marked within the left lung lobes, which contained subtle air bronchograms. Pleural fissure lines were visible between both the right middle and right caudal lobes and the accessory and left caudal lung lobes, however a significant pleural effusion was not discernable. Right lateral and dorso-ventral abdominal radiographs demonstrated no significant abnormalities.


Immune-mediated thrombocytopenia associated with angiostrongylus vasorum infection in a Jack Russell terrier.

Jo'neill E, Acke E, Tobin E, McCarthy G - Ir Vet J (2010)

Right lateral (A) and dorsoventral (B) thoracic radiographs taken on the day of referral (day four), showing a widespread mixed alveolar-interstitial lung pattern. This is visible throughout the lungfield, but is particularly marked within the left lung lobes. Pleural fissure lines are visible between both the right middle and right caudal lobes and the accessory and left caudal lung lobes, however a significant pleural effusion is not discernable.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3113836&req=5

Figure 1: Right lateral (A) and dorsoventral (B) thoracic radiographs taken on the day of referral (day four), showing a widespread mixed alveolar-interstitial lung pattern. This is visible throughout the lungfield, but is particularly marked within the left lung lobes. Pleural fissure lines are visible between both the right middle and right caudal lobes and the accessory and left caudal lung lobes, however a significant pleural effusion is not discernable.
Mentions: Haematology at the time of referral (day four) demonstrated severe thrombocytopenia (1.0 × 109/L machine count, confirmed as accurate on examination of a smear) accompanied by a mild, regenerative anaemia (PCV 0.27 L/L). Serum biochemistry demonstrated mild hyperglobulinaemia (45.7 g/L) and mild elevation of serum alkaline phosphatase (103 U/L). Thoracic radiography (Figure 1) revealed a widespread mixed alveolar-interstitial lung pattern. This was apparent throughout the lungfield, but was particularly marked within the left lung lobes, which contained subtle air bronchograms. Pleural fissure lines were visible between both the right middle and right caudal lobes and the accessory and left caudal lung lobes, however a significant pleural effusion was not discernable. Right lateral and dorso-ventral abdominal radiographs demonstrated no significant abnormalities.

Bottom Line: Haematology confirmed a platelet count of 1.0 × 10/L.Initially anaemia developed following gastrointestinal haemorrhage; however, after symptomatic treatment the dog showed a marked clinical improvement.The dog made a full clinical recovery with all treatment was withdrawn within five weeks of diagnosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: School of Agriculture, Food Sciences and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland. emma.oneill@ucd.ie.

ABSTRACT
A twenty-month-old Jack Russell terrier was presented with a four-day history of thrombocytopenia, echymotic inguinal haemorrhages, coughing and reduced exercise tolerance. Clinical examination revealed several petechial haemorrhages on the gingivae and small echymotic haemorrhages in the inguinal region, along with mild bilateral epistaxis. Haematology confirmed a platelet count of 1.0 × 10/L. Thoracic radiographs revealed a wide-spread mixed alveolar-interstitial lung pattern, apparent throughout the entire lungfield, but particularly marked within the left lung lobes. A presumptive diagnosis of immune-mediated thrombocytopenia was made and the dog was treated with vincristine and immunosuppressive doses of prednisolone. Initially anaemia developed following gastrointestinal haemorrhage; however, after symptomatic treatment the dog showed a marked clinical improvement. Evaluation for an underlying cause of the disease revealed Angiostrongylus vasorum L1 larvae on faecal analysis and treatment with fenbendazole was commenced. The dog made a full clinical recovery with all treatment was withdrawn within five weeks of diagnosis. This is the second report of immune-mediated thrombocytopenia associated with Angiostrongylus vasorum infection and it is the first to be successfully managed. The report highlights that Angiostrongylus vasorum should be considered in young dogs presented with thrombocytopenia.

No MeSH data available.


Related in: MedlinePlus