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Pleural mesothelioma in a nine-month-old dog.

Vural SA, Ozyildiz Z, Ozsoy SY - Ir Vet J (2007)

Bottom Line: Constituent tumour cells were labeled positively with antibodies against both vimentin and cytokeratin.In contrast, the same cells exhibited equivocal labeling with an antibody directed against calretinin antigen and did not label with antibodies against carcinoembryonic antigen (CEA) and milk fat globule-related antigen (MFGRA).Such tumours are rare in dogs, particularly in such a young animal.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Faculty of Veterinary Medicine, Ankara University, 06110 Diskapi/Ankara, Turkey. sevilvural@yahoo.com.

ABSTRACT
This paper reports on an unusual case of pleural epitheloid mesothelioma in a nine-month-old male, mixed breed dog. The dog was presented in-extremis and, on post mortem examination, multiple, exophytic, frequently pedunculated, yellowish-red, soft to firm masses ranging from 3 mm to 6 cm in diameter were diffusely distributed over, and attached to, the pericardial and parietal pleural surfaces. Microscopically, these masses consisted of round to partially polygonalshaped, anaplastic cells with minimal cytoplasm and hyperchromatic nuclei covering papillomatous projections or as part of more densely cellular masses. A supporting fibrovascular stroma and mitotic figures were also evident. Constituent tumour cells were labeled positively with antibodies against both vimentin and cytokeratin. In contrast, the same cells exhibited equivocal labeling with an antibody directed against calretinin antigen and did not label with antibodies against carcinoembryonic antigen (CEA) and milk fat globule-related antigen (MFGRA). Such tumours are rare in dogs, particularly in such a young animal.

No MeSH data available.


Related in: MedlinePlus

On immunohistochemistry, subtle red-brown cytoplasmic staining of neoplastic cells was observed using an antibody directed against cytokeratin. (ABC-P; original magnification × 400).
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Figure 5: On immunohistochemistry, subtle red-brown cytoplasmic staining of neoplastic cells was observed using an antibody directed against cytokeratin. (ABC-P; original magnification × 400).

Mentions: Immunohistochemically the tumour cells labelled positively with antibodies against vimentin (Figure 4) and cytokeratin (Figure 5). Inconclusive staining was obtained using calretinin antibody and no labelling was observed with the CEA and MFGRA antibodies.


Pleural mesothelioma in a nine-month-old dog.

Vural SA, Ozyildiz Z, Ozsoy SY - Ir Vet J (2007)

On immunohistochemistry, subtle red-brown cytoplasmic staining of neoplastic cells was observed using an antibody directed against cytokeratin. (ABC-P; original magnification × 400).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3113831&req=5

Figure 5: On immunohistochemistry, subtle red-brown cytoplasmic staining of neoplastic cells was observed using an antibody directed against cytokeratin. (ABC-P; original magnification × 400).
Mentions: Immunohistochemically the tumour cells labelled positively with antibodies against vimentin (Figure 4) and cytokeratin (Figure 5). Inconclusive staining was obtained using calretinin antibody and no labelling was observed with the CEA and MFGRA antibodies.

Bottom Line: Constituent tumour cells were labeled positively with antibodies against both vimentin and cytokeratin.In contrast, the same cells exhibited equivocal labeling with an antibody directed against calretinin antigen and did not label with antibodies against carcinoembryonic antigen (CEA) and milk fat globule-related antigen (MFGRA).Such tumours are rare in dogs, particularly in such a young animal.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Faculty of Veterinary Medicine, Ankara University, 06110 Diskapi/Ankara, Turkey. sevilvural@yahoo.com.

ABSTRACT
This paper reports on an unusual case of pleural epitheloid mesothelioma in a nine-month-old male, mixed breed dog. The dog was presented in-extremis and, on post mortem examination, multiple, exophytic, frequently pedunculated, yellowish-red, soft to firm masses ranging from 3 mm to 6 cm in diameter were diffusely distributed over, and attached to, the pericardial and parietal pleural surfaces. Microscopically, these masses consisted of round to partially polygonalshaped, anaplastic cells with minimal cytoplasm and hyperchromatic nuclei covering papillomatous projections or as part of more densely cellular masses. A supporting fibrovascular stroma and mitotic figures were also evident. Constituent tumour cells were labeled positively with antibodies against both vimentin and cytokeratin. In contrast, the same cells exhibited equivocal labeling with an antibody directed against calretinin antigen and did not label with antibodies against carcinoembryonic antigen (CEA) and milk fat globule-related antigen (MFGRA). Such tumours are rare in dogs, particularly in such a young animal.

No MeSH data available.


Related in: MedlinePlus