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Pleural mesothelioma in a nine-month-old dog.

Vural SA, Ozyildiz Z, Ozsoy SY - Ir Vet J (2007)

Bottom Line: Constituent tumour cells were labeled positively with antibodies against both vimentin and cytokeratin.In contrast, the same cells exhibited equivocal labeling with an antibody directed against calretinin antigen and did not label with antibodies against carcinoembryonic antigen (CEA) and milk fat globule-related antigen (MFGRA).Such tumours are rare in dogs, particularly in such a young animal.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Faculty of Veterinary Medicine, Ankara University, 06110 Diskapi/Ankara, Turkey. sevilvural@yahoo.com.

ABSTRACT
This paper reports on an unusual case of pleural epitheloid mesothelioma in a nine-month-old male, mixed breed dog. The dog was presented in-extremis and, on post mortem examination, multiple, exophytic, frequently pedunculated, yellowish-red, soft to firm masses ranging from 3 mm to 6 cm in diameter were diffusely distributed over, and attached to, the pericardial and parietal pleural surfaces. Microscopically, these masses consisted of round to partially polygonalshaped, anaplastic cells with minimal cytoplasm and hyperchromatic nuclei covering papillomatous projections or as part of more densely cellular masses. A supporting fibrovascular stroma and mitotic figures were also evident. Constituent tumour cells were labeled positively with antibodies against both vimentin and cytokeratin. In contrast, the same cells exhibited equivocal labeling with an antibody directed against calretinin antigen and did not label with antibodies against carcinoembryonic antigen (CEA) and milk fat globule-related antigen (MFGRA). Such tumours are rare in dogs, particularly in such a young animal.

No MeSH data available.


Related in: MedlinePlus

Diffuse distributed nodular, frequently pedunculated exophytic masses on pericardial and pleural surfaces.
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Figure 1: Diffuse distributed nodular, frequently pedunculated exophytic masses on pericardial and pleural surfaces.

Mentions: A nine-month-old male, mixed breed dog was presented to the clinic of the Ankara University Faculty of Veterinary Medicine in-extremis and died before clinical examination could be performed. A clinical history provided by the owner indicated that the animal had been dull, weak and dyspnoeic for the previous week. At necropsy, approximately 200 ml of serosanguinous fluid containing yellowish-red masses up to 2 cm in diameter were observed in the thoracic cavity. Multiple to coalescing, exophytic, frequently pedunculated, yellowish-red, soft to firm masses ranging from 3 mm to 6 cm in diameter were diffusely distributed over, and attached to, the pericardial and parietal pleural surfaces (Figures 1 and 2). On cut section, clear fluid was noted within a number of the larger exophytic masses. The mediastinal lymph nodes were enlarged and, on cutsection, had wet surfaces. No other significant lesions were observed in the carcass.


Pleural mesothelioma in a nine-month-old dog.

Vural SA, Ozyildiz Z, Ozsoy SY - Ir Vet J (2007)

Diffuse distributed nodular, frequently pedunculated exophytic masses on pericardial and pleural surfaces.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3113831&req=5

Figure 1: Diffuse distributed nodular, frequently pedunculated exophytic masses on pericardial and pleural surfaces.
Mentions: A nine-month-old male, mixed breed dog was presented to the clinic of the Ankara University Faculty of Veterinary Medicine in-extremis and died before clinical examination could be performed. A clinical history provided by the owner indicated that the animal had been dull, weak and dyspnoeic for the previous week. At necropsy, approximately 200 ml of serosanguinous fluid containing yellowish-red masses up to 2 cm in diameter were observed in the thoracic cavity. Multiple to coalescing, exophytic, frequently pedunculated, yellowish-red, soft to firm masses ranging from 3 mm to 6 cm in diameter were diffusely distributed over, and attached to, the pericardial and parietal pleural surfaces (Figures 1 and 2). On cut section, clear fluid was noted within a number of the larger exophytic masses. The mediastinal lymph nodes were enlarged and, on cutsection, had wet surfaces. No other significant lesions were observed in the carcass.

Bottom Line: Constituent tumour cells were labeled positively with antibodies against both vimentin and cytokeratin.In contrast, the same cells exhibited equivocal labeling with an antibody directed against calretinin antigen and did not label with antibodies against carcinoembryonic antigen (CEA) and milk fat globule-related antigen (MFGRA).Such tumours are rare in dogs, particularly in such a young animal.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Faculty of Veterinary Medicine, Ankara University, 06110 Diskapi/Ankara, Turkey. sevilvural@yahoo.com.

ABSTRACT
This paper reports on an unusual case of pleural epitheloid mesothelioma in a nine-month-old male, mixed breed dog. The dog was presented in-extremis and, on post mortem examination, multiple, exophytic, frequently pedunculated, yellowish-red, soft to firm masses ranging from 3 mm to 6 cm in diameter were diffusely distributed over, and attached to, the pericardial and parietal pleural surfaces. Microscopically, these masses consisted of round to partially polygonalshaped, anaplastic cells with minimal cytoplasm and hyperchromatic nuclei covering papillomatous projections or as part of more densely cellular masses. A supporting fibrovascular stroma and mitotic figures were also evident. Constituent tumour cells were labeled positively with antibodies against both vimentin and cytokeratin. In contrast, the same cells exhibited equivocal labeling with an antibody directed against calretinin antigen and did not label with antibodies against carcinoembryonic antigen (CEA) and milk fat globule-related antigen (MFGRA). Such tumours are rare in dogs, particularly in such a young animal.

No MeSH data available.


Related in: MedlinePlus