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Correlation of the Havemeyer endoscopic laryngeal grading system with histopathological changes in equine Cricoarytenoideus dorsalis muscles.

Collins N, Milne E, Hahn C, Dixon P - Ir Vet J (2009)

Bottom Line: A semi-quantitative histopathological scoring system was used to grade the severity of histopathological lesions consistent with RLN in the left CAD muscle of each horse.However, a wide spread of muscle histopathological scores was obtained, particularly from horses with Havemeyer sub-grades II.1, III.1 and III.2.In conclusion, the Havemeyer endoscopic laryngeal grading system was found to broadly correlate with histopathological changes consistent with RLN in equine cricoarytenoideus dorsalis muscle.

View Article: PubMed Central - HTML - PubMed

Affiliation: The Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, EH25 9RG, Scotland. niamhlynne@hotmail.com.

ABSTRACT
The establishment of a single validated endoscopic laryngeal grading system for assessing recurrent laryngeal neuropathy (RLN) is desirable to facilitate direct comparisons between the findings of different clinical and research groups worldwide. The objective of this study was to assess the relationship between the Havemeyer endoscopic laryngeal grading system and histopathological changes consistent with RLN in the left cricoarytenoideus dorsalis (CAD) muscle of horses of different breeds with a full range of clinical severities of RLN, i.e., from normal endoscopic laryngeal function to complete laryngeal hemiplegia. Endoscopic grading of laryngeal function of 22 horses was performed using the Havemeyer endoscopic laryngeal grading system. A biopsy sample of the left CAD muscle was obtained from each horse, either at post mortem examination (n = 16), or during routine laryngoplasty surgery (n = 6). A semi-quantitative histopathological scoring system was used to grade the severity of histopathological lesions consistent with RLN in the left CAD muscle of each horse. A significant positive correlation (rs = 0.705, p < 0.001) was found between the Havemeyer grades and sub-grades of laryngeal function and the semi-quantitative assessment of histopathological lesions consistent with RLN in the left CAD muscle. However, a wide spread of muscle histopathological scores was obtained, particularly from horses with Havemeyer sub-grades II.1, III.1 and III.2. In conclusion, the Havemeyer endoscopic laryngeal grading system was found to broadly correlate with histopathological changes consistent with RLN in equine cricoarytenoideus dorsalis muscle.

No MeSH data available.


Related in: MedlinePlus

Modified scatterplot comparing the left CAD myopathy histological score and the Havemeyer endoscopic grade of left laryngeal function of the horses in the study. The values of two horses (Horse 1 and Horse 2) with grade I laryngeal function and left CAD myopathy histological scores of 10.5 have been graphically altered to make both visible. CAD = cricoarytenoideus dorsalis muscle.
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Figure 1: Modified scatterplot comparing the left CAD myopathy histological score and the Havemeyer endoscopic grade of left laryngeal function of the horses in the study. The values of two horses (Horse 1 and Horse 2) with grade I laryngeal function and left CAD myopathy histological scores of 10.5 have been graphically altered to make both visible. CAD = cricoarytenoideus dorsalis muscle.

Mentions: A statistically significant positive correlation was found between the Havemeyer grades and sub-grades of laryngeal function, and the left CAD myopathy histological score (rs = 0.705, p < 0.001) (Figure 1). Muscles from horses with grades I and II.2 laryngeal function showed mild neurogenic change (myopathy histological scores 8-10.5) and horses with grades III.3 and IV laryngeal function showed severe neurogenic changes (myopathy histological scores 21.5-24). However, a wider range of myopathy histological scores was found for grades II.1 (8.5-16.5); III.1 (8.5-18) and III.2 (14.5-24.5) (Table 1).


Correlation of the Havemeyer endoscopic laryngeal grading system with histopathological changes in equine Cricoarytenoideus dorsalis muscles.

Collins N, Milne E, Hahn C, Dixon P - Ir Vet J (2009)

Modified scatterplot comparing the left CAD myopathy histological score and the Havemeyer endoscopic grade of left laryngeal function of the horses in the study. The values of two horses (Horse 1 and Horse 2) with grade I laryngeal function and left CAD myopathy histological scores of 10.5 have been graphically altered to make both visible. CAD = cricoarytenoideus dorsalis muscle.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3113812&req=5

Figure 1: Modified scatterplot comparing the left CAD myopathy histological score and the Havemeyer endoscopic grade of left laryngeal function of the horses in the study. The values of two horses (Horse 1 and Horse 2) with grade I laryngeal function and left CAD myopathy histological scores of 10.5 have been graphically altered to make both visible. CAD = cricoarytenoideus dorsalis muscle.
Mentions: A statistically significant positive correlation was found between the Havemeyer grades and sub-grades of laryngeal function, and the left CAD myopathy histological score (rs = 0.705, p < 0.001) (Figure 1). Muscles from horses with grades I and II.2 laryngeal function showed mild neurogenic change (myopathy histological scores 8-10.5) and horses with grades III.3 and IV laryngeal function showed severe neurogenic changes (myopathy histological scores 21.5-24). However, a wider range of myopathy histological scores was found for grades II.1 (8.5-16.5); III.1 (8.5-18) and III.2 (14.5-24.5) (Table 1).

Bottom Line: A semi-quantitative histopathological scoring system was used to grade the severity of histopathological lesions consistent with RLN in the left CAD muscle of each horse.However, a wide spread of muscle histopathological scores was obtained, particularly from horses with Havemeyer sub-grades II.1, III.1 and III.2.In conclusion, the Havemeyer endoscopic laryngeal grading system was found to broadly correlate with histopathological changes consistent with RLN in equine cricoarytenoideus dorsalis muscle.

View Article: PubMed Central - HTML - PubMed

Affiliation: The Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, EH25 9RG, Scotland. niamhlynne@hotmail.com.

ABSTRACT
The establishment of a single validated endoscopic laryngeal grading system for assessing recurrent laryngeal neuropathy (RLN) is desirable to facilitate direct comparisons between the findings of different clinical and research groups worldwide. The objective of this study was to assess the relationship between the Havemeyer endoscopic laryngeal grading system and histopathological changes consistent with RLN in the left cricoarytenoideus dorsalis (CAD) muscle of horses of different breeds with a full range of clinical severities of RLN, i.e., from normal endoscopic laryngeal function to complete laryngeal hemiplegia. Endoscopic grading of laryngeal function of 22 horses was performed using the Havemeyer endoscopic laryngeal grading system. A biopsy sample of the left CAD muscle was obtained from each horse, either at post mortem examination (n = 16), or during routine laryngoplasty surgery (n = 6). A semi-quantitative histopathological scoring system was used to grade the severity of histopathological lesions consistent with RLN in the left CAD muscle of each horse. A significant positive correlation (rs = 0.705, p < 0.001) was found between the Havemeyer grades and sub-grades of laryngeal function and the semi-quantitative assessment of histopathological lesions consistent with RLN in the left CAD muscle. However, a wide spread of muscle histopathological scores was obtained, particularly from horses with Havemeyer sub-grades II.1, III.1 and III.2. In conclusion, the Havemeyer endoscopic laryngeal grading system was found to broadly correlate with histopathological changes consistent with RLN in equine cricoarytenoideus dorsalis muscle.

No MeSH data available.


Related in: MedlinePlus