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Physiological synaptic signals initiate sequential spikes at soma of cortical pyramidal neurons.

Ge R, Qian H, Wang JH - Mol Brain (2011)

Bottom Line: In dual recordings from the soma vs. axon, the signals recorded in vivo induce somatic spikes with higher capacity, which is associated with lower somatic thresholds and shorter refractory periods mediated by voltage-gated sodium channels.The introduction of these parameters from the soma and axon into NEURON model simulates sequential spikes being somatic in origin.Physiological signals integrated from synaptic inputs primarily trigger the soma to encode neuronal digital spikes.

View Article: PubMed Central - HTML - PubMed

Affiliation: State Key Lab for Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

ABSTRACT
The neurons in the brain produce sequential spikes as the digital codes whose various patterns manage well-organized cognitions and behaviors. A source for the physiologically integrated synaptic signals to initiate digital spikes remains unknown, which we studied at pyramidal neurons of cortical slices. In dual recordings from the soma vs. axon, the signals recorded in vivo induce somatic spikes with higher capacity, which is associated with lower somatic thresholds and shorter refractory periods mediated by voltage-gated sodium channels. The introduction of these parameters from the soma and axon into NEURON model simulates sequential spikes being somatic in origin. Physiological signals integrated from synaptic inputs primarily trigger the soma to encode neuronal digital spikes.

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In vivo depolarization signals for spike initiation and subthreshold are long-time in nature. A) The integrated synaptic signals induce spikes. B) shows the integrated synaptic signals at subthreshold level (top panel) and the expanded waveforms (bottoms), which appear steady-state pattern (square pulse) and fluctuation one (cosine). C) shows number of EPSPs in vivo vs. signal durations, which fall into a range of 50~1600 ms. D) illustrates the percentages for steady-state pattern and fluctuation one analyzed from total in vivo signals (n = 11 neurons).
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Figure 1: In vivo depolarization signals for spike initiation and subthreshold are long-time in nature. A) The integrated synaptic signals induce spikes. B) shows the integrated synaptic signals at subthreshold level (top panel) and the expanded waveforms (bottoms), which appear steady-state pattern (square pulse) and fluctuation one (cosine). C) shows number of EPSPs in vivo vs. signal durations, which fall into a range of 50~1600 ms. D) illustrates the percentages for steady-state pattern and fluctuation one analyzed from total in vivo signals (n = 11 neurons).

Mentions: The neurons integrate the signals from numerous synapses and produce sequential spikes as the digital codes to carry various messages under the physiological conditions [12,13]. These integrated signals in vivo are long-time in nature, and their depolarization pulses induce sequential spikes [14-18] and Figure 1). A source for these in vivo signals to initiate sequential spikes has not been documented, which we have investigated at cortical pyramidal neurons by dual- recording their soma and axonal bleb simultaneously.


Physiological synaptic signals initiate sequential spikes at soma of cortical pyramidal neurons.

Ge R, Qian H, Wang JH - Mol Brain (2011)

In vivo depolarization signals for spike initiation and subthreshold are long-time in nature. A) The integrated synaptic signals induce spikes. B) shows the integrated synaptic signals at subthreshold level (top panel) and the expanded waveforms (bottoms), which appear steady-state pattern (square pulse) and fluctuation one (cosine). C) shows number of EPSPs in vivo vs. signal durations, which fall into a range of 50~1600 ms. D) illustrates the percentages for steady-state pattern and fluctuation one analyzed from total in vivo signals (n = 11 neurons).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3113741&req=5

Figure 1: In vivo depolarization signals for spike initiation and subthreshold are long-time in nature. A) The integrated synaptic signals induce spikes. B) shows the integrated synaptic signals at subthreshold level (top panel) and the expanded waveforms (bottoms), which appear steady-state pattern (square pulse) and fluctuation one (cosine). C) shows number of EPSPs in vivo vs. signal durations, which fall into a range of 50~1600 ms. D) illustrates the percentages for steady-state pattern and fluctuation one analyzed from total in vivo signals (n = 11 neurons).
Mentions: The neurons integrate the signals from numerous synapses and produce sequential spikes as the digital codes to carry various messages under the physiological conditions [12,13]. These integrated signals in vivo are long-time in nature, and their depolarization pulses induce sequential spikes [14-18] and Figure 1). A source for these in vivo signals to initiate sequential spikes has not been documented, which we have investigated at cortical pyramidal neurons by dual- recording their soma and axonal bleb simultaneously.

Bottom Line: In dual recordings from the soma vs. axon, the signals recorded in vivo induce somatic spikes with higher capacity, which is associated with lower somatic thresholds and shorter refractory periods mediated by voltage-gated sodium channels.The introduction of these parameters from the soma and axon into NEURON model simulates sequential spikes being somatic in origin.Physiological signals integrated from synaptic inputs primarily trigger the soma to encode neuronal digital spikes.

View Article: PubMed Central - HTML - PubMed

Affiliation: State Key Lab for Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

ABSTRACT
The neurons in the brain produce sequential spikes as the digital codes whose various patterns manage well-organized cognitions and behaviors. A source for the physiologically integrated synaptic signals to initiate digital spikes remains unknown, which we studied at pyramidal neurons of cortical slices. In dual recordings from the soma vs. axon, the signals recorded in vivo induce somatic spikes with higher capacity, which is associated with lower somatic thresholds and shorter refractory periods mediated by voltage-gated sodium channels. The introduction of these parameters from the soma and axon into NEURON model simulates sequential spikes being somatic in origin. Physiological signals integrated from synaptic inputs primarily trigger the soma to encode neuronal digital spikes.

Show MeSH
Related in: MedlinePlus