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Vitamin D and clinical disease progression in HIV infection: results from the EuroSIDA study

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Mentions: Thirty-six percent of patients had 25(OH) levels below 12 ng/ml, 31,3% between 12.1 and 20 ng/ml, and 32.7% above 20 ng/ml. In a cross sectional analysis, older persons, patients of Black ethnic origin, living outside Southern Europe and Argentina, sampled during winter, and infected with HIV through non-homosexual exposure were at higher risk of having low 25(OH)D levels, while patients receiving protease inhibitors were at a lower risk. Compared to those in the lowest 25(OH)D tertile, those in the medium and high tertiles had a significantly lower risk of clinical progression. Adjusted incidence rate ratios (IRR; see figure 1) for all-cause mortality were 0.68 (95%CI : 0,47-0,99, P=0.045) and 0.56 (95%CI : 0.37-0.8, P=0.009), and for AIDS events were 0.58 (95%CI : 0,39-0,87, P=0.0086) and 0.61 (95%CI : 0.40-0.93, P=0.020), for the medium and high tertiles, respectively. There was a non-significant reduced incidence of non-AIDS defining events in the medium and high tertiles, and a significant lower IRR of non-AIDS related death in the highest 25(OH)D tertile : 0.60 (95%CI : 0.37-0.98, P=0.043).


Vitamin D and clinical disease progression in HIV infection: results from the EuroSIDA study
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3112858&req=5

Mentions: Thirty-six percent of patients had 25(OH) levels below 12 ng/ml, 31,3% between 12.1 and 20 ng/ml, and 32.7% above 20 ng/ml. In a cross sectional analysis, older persons, patients of Black ethnic origin, living outside Southern Europe and Argentina, sampled during winter, and infected with HIV through non-homosexual exposure were at higher risk of having low 25(OH)D levels, while patients receiving protease inhibitors were at a lower risk. Compared to those in the lowest 25(OH)D tertile, those in the medium and high tertiles had a significantly lower risk of clinical progression. Adjusted incidence rate ratios (IRR; see figure 1) for all-cause mortality were 0.68 (95%CI : 0,47-0,99, P=0.045) and 0.56 (95%CI : 0.37-0.8, P=0.009), and for AIDS events were 0.58 (95%CI : 0,39-0,87, P=0.0086) and 0.61 (95%CI : 0.40-0.93, P=0.020), for the medium and high tertiles, respectively. There was a non-significant reduced incidence of non-AIDS defining events in the medium and high tertiles, and a significant lower IRR of non-AIDS related death in the highest 25(OH)D tertile : 0.60 (95%CI : 0.37-0.98, P=0.043).

View Article: PubMed Central - HTML

No MeSH data available.