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Effect of Ligusticum wallichii aqueous extract on oxidative injury and immunity activity in myocardial ischemic reperfusion rats.

Zengyong Q, Jiangwei M, Huajin L - Int J Mol Sci (2011)

Bottom Line: The hearts were compared for indices of oxidative stress and immunity activities.Administration of Ligusticum wallichi extract significantly decreased serum TNF-α, IL-6, IL-8, NO, MIP-1α, CRP and myocardium MDA levels, and serum CK, LDH and AST activities, and increased myocardium Na(+)-K(+)-ATPase, Ca(2+)-Mg(2+)-ATPase, NOS, SOD, CAT, GSH-Px and TAOC activities.The results indicate that Ligusticum wallichii extract treatment can enhance myocardial antioxidant status and improve the immunity profile in ischemic-reperfusion rats.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Fengxian Branch of Shanghai 6th People's Hospital, Shanghai, 201400 China; E-Mails: liuhjdrfx@sina.cn (L.H.); E-Mail: majwdrfx@sina.cn (M.J.).

ABSTRACT
We investigated the efficacy of Ligusticum wallichi aqueous extract (LWE) for myocardial protection against ischemia-reperfusion injury. Rats were fed for five weeks with either a control diet (sham and ischemia reperfusion (IR) model control groups) or a diet mixed with 0.2%, 0.4% or 0.6% Ligusticum wallichi extract. At the end of the five week period, hearts were excised and subjected to global ischemia for 30 min followed by reperfusion for 2 h. The hearts were compared for indices of oxidative stress and immunity activities. Administration of Ligusticum wallichi extract significantly decreased serum TNF-α, IL-6, IL-8, NO, MIP-1α, CRP and myocardium MDA levels, and serum CK, LDH and AST activities, and increased myocardium Na(+)-K(+)-ATPase, Ca(2+)-Mg(2+)-ATPase, NOS, SOD, CAT, GSH-Px and TAOC activities. The results indicate that Ligusticum wallichii extract treatment can enhance myocardial antioxidant status and improve the immunity profile in ischemic-reperfusion rats.

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Effect of Ligusticum wallichii extract on myocardium MDA and GSH levels. b P < 0.01 compared with SO control group; d P < 0.01 compared with IR model group. Group 1: sham operation (SO); group 2: ischemia reperfusion (IR); group 3: Ligusticum wallichii extract (LWE) 0.2 g/kg body weight; group 4: LWE 0.4 g/kg body weight; group 5: LWE 0.6 g/kg body weight.
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f5-ijms-12-01991: Effect of Ligusticum wallichii extract on myocardium MDA and GSH levels. b P < 0.01 compared with SO control group; d P < 0.01 compared with IR model group. Group 1: sham operation (SO); group 2: ischemia reperfusion (IR); group 3: Ligusticum wallichii extract (LWE) 0.2 g/kg body weight; group 4: LWE 0.4 g/kg body weight; group 5: LWE 0.6 g/kg body weight.

Mentions: Compared with the SO rats, the myocardium MDA concentration was markedly higher in the IR model rats, whereas myocardium GSH level was significantly lower in IR model rats (Figure 5). Ligusticum wallichii extract treatment significantly lowered myocardium MDA and enhanced GSH levels when compared with IR model group.


Effect of Ligusticum wallichii aqueous extract on oxidative injury and immunity activity in myocardial ischemic reperfusion rats.

Zengyong Q, Jiangwei M, Huajin L - Int J Mol Sci (2011)

Effect of Ligusticum wallichii extract on myocardium MDA and GSH levels. b P < 0.01 compared with SO control group; d P < 0.01 compared with IR model group. Group 1: sham operation (SO); group 2: ischemia reperfusion (IR); group 3: Ligusticum wallichii extract (LWE) 0.2 g/kg body weight; group 4: LWE 0.4 g/kg body weight; group 5: LWE 0.6 g/kg body weight.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3111646&req=5

f5-ijms-12-01991: Effect of Ligusticum wallichii extract on myocardium MDA and GSH levels. b P < 0.01 compared with SO control group; d P < 0.01 compared with IR model group. Group 1: sham operation (SO); group 2: ischemia reperfusion (IR); group 3: Ligusticum wallichii extract (LWE) 0.2 g/kg body weight; group 4: LWE 0.4 g/kg body weight; group 5: LWE 0.6 g/kg body weight.
Mentions: Compared with the SO rats, the myocardium MDA concentration was markedly higher in the IR model rats, whereas myocardium GSH level was significantly lower in IR model rats (Figure 5). Ligusticum wallichii extract treatment significantly lowered myocardium MDA and enhanced GSH levels when compared with IR model group.

Bottom Line: The hearts were compared for indices of oxidative stress and immunity activities.Administration of Ligusticum wallichi extract significantly decreased serum TNF-α, IL-6, IL-8, NO, MIP-1α, CRP and myocardium MDA levels, and serum CK, LDH and AST activities, and increased myocardium Na(+)-K(+)-ATPase, Ca(2+)-Mg(2+)-ATPase, NOS, SOD, CAT, GSH-Px and TAOC activities.The results indicate that Ligusticum wallichii extract treatment can enhance myocardial antioxidant status and improve the immunity profile in ischemic-reperfusion rats.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Fengxian Branch of Shanghai 6th People's Hospital, Shanghai, 201400 China; E-Mails: liuhjdrfx@sina.cn (L.H.); E-Mail: majwdrfx@sina.cn (M.J.).

ABSTRACT
We investigated the efficacy of Ligusticum wallichi aqueous extract (LWE) for myocardial protection against ischemia-reperfusion injury. Rats were fed for five weeks with either a control diet (sham and ischemia reperfusion (IR) model control groups) or a diet mixed with 0.2%, 0.4% or 0.6% Ligusticum wallichi extract. At the end of the five week period, hearts were excised and subjected to global ischemia for 30 min followed by reperfusion for 2 h. The hearts were compared for indices of oxidative stress and immunity activities. Administration of Ligusticum wallichi extract significantly decreased serum TNF-α, IL-6, IL-8, NO, MIP-1α, CRP and myocardium MDA levels, and serum CK, LDH and AST activities, and increased myocardium Na(+)-K(+)-ATPase, Ca(2+)-Mg(2+)-ATPase, NOS, SOD, CAT, GSH-Px and TAOC activities. The results indicate that Ligusticum wallichii extract treatment can enhance myocardial antioxidant status and improve the immunity profile in ischemic-reperfusion rats.

Show MeSH
Related in: MedlinePlus