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Effect of Ligusticum wallichii aqueous extract on oxidative injury and immunity activity in myocardial ischemic reperfusion rats.

Zengyong Q, Jiangwei M, Huajin L - Int J Mol Sci (2011)

Bottom Line: The hearts were compared for indices of oxidative stress and immunity activities.Administration of Ligusticum wallichi extract significantly decreased serum TNF-α, IL-6, IL-8, NO, MIP-1α, CRP and myocardium MDA levels, and serum CK, LDH and AST activities, and increased myocardium Na(+)-K(+)-ATPase, Ca(2+)-Mg(2+)-ATPase, NOS, SOD, CAT, GSH-Px and TAOC activities.The results indicate that Ligusticum wallichii extract treatment can enhance myocardial antioxidant status and improve the immunity profile in ischemic-reperfusion rats.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Fengxian Branch of Shanghai 6th People's Hospital, Shanghai, 201400 China; E-Mails: liuhjdrfx@sina.cn (L.H.); E-Mail: majwdrfx@sina.cn (M.J.).

ABSTRACT
We investigated the efficacy of Ligusticum wallichi aqueous extract (LWE) for myocardial protection against ischemia-reperfusion injury. Rats were fed for five weeks with either a control diet (sham and ischemia reperfusion (IR) model control groups) or a diet mixed with 0.2%, 0.4% or 0.6% Ligusticum wallichi extract. At the end of the five week period, hearts were excised and subjected to global ischemia for 30 min followed by reperfusion for 2 h. The hearts were compared for indices of oxidative stress and immunity activities. Administration of Ligusticum wallichi extract significantly decreased serum TNF-α, IL-6, IL-8, NO, MIP-1α, CRP and myocardium MDA levels, and serum CK, LDH and AST activities, and increased myocardium Na(+)-K(+)-ATPase, Ca(2+)-Mg(2+)-ATPase, NOS, SOD, CAT, GSH-Px and TAOC activities. The results indicate that Ligusticum wallichii extract treatment can enhance myocardial antioxidant status and improve the immunity profile in ischemic-reperfusion rats.

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Effect of Ligusticum wallichii extract on serum CRP (A) and MIP-1α (B) levels. b P < 0.01 compared with SO control group; d P < 0.01 compared with IR model group. Group 1: sham operation (SO); group 2: ischemia reperfusion (IR); group 3: Ligusticum wallichii extract (LWE) 0.2 g/kg body weight; group 4: LWE 0.4 g/kg body weight; group 5: LWE 0.6 g/kg body weight.
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f2-ijms-12-01991: Effect of Ligusticum wallichii extract on serum CRP (A) and MIP-1α (B) levels. b P < 0.01 compared with SO control group; d P < 0.01 compared with IR model group. Group 1: sham operation (SO); group 2: ischemia reperfusion (IR); group 3: Ligusticum wallichii extract (LWE) 0.2 g/kg body weight; group 4: LWE 0.4 g/kg body weight; group 5: LWE 0.6 g/kg body weight.

Mentions: The effect of Ligusticum wallichii extract on serum MIP-1α and CRP levels is shown in Figure 2. The levels of serum MIP-1α and CRP were significantly enhanced by IR operation treatment in comparison with the SO control rats. Similarly, administration of the Ligusticum wallichii extract (0.2%, 0.4% and 0.6%) significantly reduced serum MIP-1α and CRP levels in a dose-dependent manner.


Effect of Ligusticum wallichii aqueous extract on oxidative injury and immunity activity in myocardial ischemic reperfusion rats.

Zengyong Q, Jiangwei M, Huajin L - Int J Mol Sci (2011)

Effect of Ligusticum wallichii extract on serum CRP (A) and MIP-1α (B) levels. b P < 0.01 compared with SO control group; d P < 0.01 compared with IR model group. Group 1: sham operation (SO); group 2: ischemia reperfusion (IR); group 3: Ligusticum wallichii extract (LWE) 0.2 g/kg body weight; group 4: LWE 0.4 g/kg body weight; group 5: LWE 0.6 g/kg body weight.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3111646&req=5

f2-ijms-12-01991: Effect of Ligusticum wallichii extract on serum CRP (A) and MIP-1α (B) levels. b P < 0.01 compared with SO control group; d P < 0.01 compared with IR model group. Group 1: sham operation (SO); group 2: ischemia reperfusion (IR); group 3: Ligusticum wallichii extract (LWE) 0.2 g/kg body weight; group 4: LWE 0.4 g/kg body weight; group 5: LWE 0.6 g/kg body weight.
Mentions: The effect of Ligusticum wallichii extract on serum MIP-1α and CRP levels is shown in Figure 2. The levels of serum MIP-1α and CRP were significantly enhanced by IR operation treatment in comparison with the SO control rats. Similarly, administration of the Ligusticum wallichii extract (0.2%, 0.4% and 0.6%) significantly reduced serum MIP-1α and CRP levels in a dose-dependent manner.

Bottom Line: The hearts were compared for indices of oxidative stress and immunity activities.Administration of Ligusticum wallichi extract significantly decreased serum TNF-α, IL-6, IL-8, NO, MIP-1α, CRP and myocardium MDA levels, and serum CK, LDH and AST activities, and increased myocardium Na(+)-K(+)-ATPase, Ca(2+)-Mg(2+)-ATPase, NOS, SOD, CAT, GSH-Px and TAOC activities.The results indicate that Ligusticum wallichii extract treatment can enhance myocardial antioxidant status and improve the immunity profile in ischemic-reperfusion rats.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Fengxian Branch of Shanghai 6th People's Hospital, Shanghai, 201400 China; E-Mails: liuhjdrfx@sina.cn (L.H.); E-Mail: majwdrfx@sina.cn (M.J.).

ABSTRACT
We investigated the efficacy of Ligusticum wallichi aqueous extract (LWE) for myocardial protection against ischemia-reperfusion injury. Rats were fed for five weeks with either a control diet (sham and ischemia reperfusion (IR) model control groups) or a diet mixed with 0.2%, 0.4% or 0.6% Ligusticum wallichi extract. At the end of the five week period, hearts were excised and subjected to global ischemia for 30 min followed by reperfusion for 2 h. The hearts were compared for indices of oxidative stress and immunity activities. Administration of Ligusticum wallichi extract significantly decreased serum TNF-α, IL-6, IL-8, NO, MIP-1α, CRP and myocardium MDA levels, and serum CK, LDH and AST activities, and increased myocardium Na(+)-K(+)-ATPase, Ca(2+)-Mg(2+)-ATPase, NOS, SOD, CAT, GSH-Px and TAOC activities. The results indicate that Ligusticum wallichii extract treatment can enhance myocardial antioxidant status and improve the immunity profile in ischemic-reperfusion rats.

Show MeSH
Related in: MedlinePlus