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Chitin-based materials in tissue engineering: applications in soft tissue and epithelial organ.

Yang TL - Int J Mol Sci (2011)

Bottom Line: Because of the attractive features of chitin-based materials, many characteristics beneficial to tissue regeneration including the preservation of cellular phenotype, binding and enhancement of bioactive factors, control of gene expression, and synthesis and deposition of tissue-specific extracellular matrix are well-regulated by chitin-based scaffolds.These scaffolds can be used in repairing body surface linings, reconstructing tissue structures, regenerating connective tissue, and supporting nerve and vascular growth and connection.The novel use of these scaffolds in promoting the regeneration of various tissues originating from the epithelium and soft tissue demonstrates that these chitin-based materials have versatile properties and functionality and serve as promising substrates for a great number of future applications.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology, National Taiwan University Hospital and College of Medicine, Taipei, 100, Taiwan; E-Mail: yangtl@ntu.edu.tw ; Tel.: +886-2-23123456 ext. 63526;

ABSTRACT
Chitin-based materials and their derivatives are receiving increased attention in tissue engineering because of their unique and appealing biological properties. In this review, we summarize the biomedical potential of chitin-based materials, specifically focusing on chitosan, in tissue engineering approaches for epithelial and soft tissues. Both types of tissues play an important role in supporting anatomical structures and physiological functions. Because of the attractive features of chitin-based materials, many characteristics beneficial to tissue regeneration including the preservation of cellular phenotype, binding and enhancement of bioactive factors, control of gene expression, and synthesis and deposition of tissue-specific extracellular matrix are well-regulated by chitin-based scaffolds. These scaffolds can be used in repairing body surface linings, reconstructing tissue structures, regenerating connective tissue, and supporting nerve and vascular growth and connection. The novel use of these scaffolds in promoting the regeneration of various tissues originating from the epithelium and soft tissue demonstrates that these chitin-based materials have versatile properties and functionality and serve as promising substrates for a great number of future applications.

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Molecular structures of chitin, chitosan, and protonated chitosan polymer.
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f1-ijms-12-01936: Molecular structures of chitin, chitosan, and protonated chitosan polymer.

Mentions: Chitin is the second most abundant natural polymer and is commonly found in the exoskeletons of crustacean and insects as well as the cell walls of fungi. Most chitin applications are based on its deacetylated form, chitosan. Chitosan is composed of glucosamine and N-acetyl glucosamine, which are linked in a β (1–4) manner (Figure 1). The molecular weight and degree of deacetylation, which are critical in determining the characteristics of chitosan, depend on the source and production process used [1].


Chitin-based materials in tissue engineering: applications in soft tissue and epithelial organ.

Yang TL - Int J Mol Sci (2011)

Molecular structures of chitin, chitosan, and protonated chitosan polymer.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3111643&req=5

f1-ijms-12-01936: Molecular structures of chitin, chitosan, and protonated chitosan polymer.
Mentions: Chitin is the second most abundant natural polymer and is commonly found in the exoskeletons of crustacean and insects as well as the cell walls of fungi. Most chitin applications are based on its deacetylated form, chitosan. Chitosan is composed of glucosamine and N-acetyl glucosamine, which are linked in a β (1–4) manner (Figure 1). The molecular weight and degree of deacetylation, which are critical in determining the characteristics of chitosan, depend on the source and production process used [1].

Bottom Line: Because of the attractive features of chitin-based materials, many characteristics beneficial to tissue regeneration including the preservation of cellular phenotype, binding and enhancement of bioactive factors, control of gene expression, and synthesis and deposition of tissue-specific extracellular matrix are well-regulated by chitin-based scaffolds.These scaffolds can be used in repairing body surface linings, reconstructing tissue structures, regenerating connective tissue, and supporting nerve and vascular growth and connection.The novel use of these scaffolds in promoting the regeneration of various tissues originating from the epithelium and soft tissue demonstrates that these chitin-based materials have versatile properties and functionality and serve as promising substrates for a great number of future applications.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology, National Taiwan University Hospital and College of Medicine, Taipei, 100, Taiwan; E-Mail: yangtl@ntu.edu.tw ; Tel.: +886-2-23123456 ext. 63526;

ABSTRACT
Chitin-based materials and their derivatives are receiving increased attention in tissue engineering because of their unique and appealing biological properties. In this review, we summarize the biomedical potential of chitin-based materials, specifically focusing on chitosan, in tissue engineering approaches for epithelial and soft tissues. Both types of tissues play an important role in supporting anatomical structures and physiological functions. Because of the attractive features of chitin-based materials, many characteristics beneficial to tissue regeneration including the preservation of cellular phenotype, binding and enhancement of bioactive factors, control of gene expression, and synthesis and deposition of tissue-specific extracellular matrix are well-regulated by chitin-based scaffolds. These scaffolds can be used in repairing body surface linings, reconstructing tissue structures, regenerating connective tissue, and supporting nerve and vascular growth and connection. The novel use of these scaffolds in promoting the regeneration of various tissues originating from the epithelium and soft tissue demonstrates that these chitin-based materials have versatile properties and functionality and serve as promising substrates for a great number of future applications.

Show MeSH