Mutual inactivation of Notch receptors and ligands facilitates developmental patterning.
Bottom Line: It generally remains unclear, however, how this mutual inactivation and the resulting switching behavior can impact developmental patterning circuits.For lateral inhibition, we find that mutual inactivation speeds up patterning dynamics, relieves the need for cooperative regulatory interactions, and expands the range of parameter values that permit pattern formation, compared to canonical models.Together, these results provide a framework for analysis of more complex Notch-dependent developmental systems.
Affiliation: Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California, USA.Show MeSH
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Mentions: Wing vein formation in the developing fly is a classic model system for studying the generation of sharp boundaries. In the Drosophila wing, there are four longitudinal veins that include several rows of cells that are more compact and have darker pigmentation than intervein cells. The position of the wing veins in the wing imaginal disk is initiated by EGF signaling during the early stages of larva development . The final form (position and width) of the wing veins is refined by several subsequent processes. Notch signaling has been shown to specifically control the sharpening of the boundary between pro-vein (the region competent to produce vein fates) and intervein regions in the wing disc , . In this system, the Delta production rate is controlled by a gradient of veinless expression diminishing outward from the center of the pro-vein region (Fig. 2A, left). Notch signaling is observed in two sharply defined side-bands, which restrict further vein development to the region between them (Fig. 2A, right).
Affiliation: Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California, USA.