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Frequency specific modulation of human somatosensory cortex.

Feurra M, Paulus W, Walsh V, Kanai R - Front Psychol (2011)

Bottom Line: Oscillatory neuronal activities are commonly observed in response to sensory stimulation.However, their functional roles are still the subject of debate.These findings highlight the frequency dependency of effective tACS over SI with the effective frequencies corresponding to those observed in previous electroencephalography/magnetoencephalography studies of tactile perception.

View Article: PubMed Central - PubMed

Affiliation: Institute of Cognitive Neuroscience, Department of Psychology, University College London London, UK.

ABSTRACT
Oscillatory neuronal activities are commonly observed in response to sensory stimulation. However, their functional roles are still the subject of debate. One-way to probe the roles of oscillatory neural activities is to deliver alternating current to the cortex at biologically relevant frequencies and examine whether such stimulation influences perception and cognition. In this study, we tested whether transcranial alternating current stimulation (tACS) over the primary somatosensory cortex (SI) could elicit tactile sensations in humans in a frequency-dependent manner. We tested the effectiveness of tACS over SI at frequency bands ranging from 2 to 70 Hz. Our results show that stimulation in alpha (10-14 Hz) and high gamma (52-70 Hz) frequency range produces a tactile sensation in the contralateral hand. A weaker effect was also observed for beta (16-20 Hz) stimulation. These findings highlight the frequency dependency of effective tACS over SI with the effective frequencies corresponding to those observed in previous electroencephalography/magnetoencephalography studies of tactile perception. Our present study suggests that tACS could be used as a powerful online stimulation technique to reveal the causal roles of oscillatory brain activities.

No MeSH data available.


Related in: MedlinePlus

Tactile sensation ratings per frequency band. The rating score scaled from 0 (no sensation at all) to 3 (maximum sensation). The error bars correspond to 1 SEM. Conditions with significant p-values of post hoc comparisons are labeled with one asterisk (*) for p < 0.05 which indicates significant differences between the experimental conditions. Changes of tactile rating are evident for alpha and gamma bands.
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Figure 1: Tactile sensation ratings per frequency band. The rating score scaled from 0 (no sensation at all) to 3 (maximum sensation). The error bars correspond to 1 SEM. Conditions with significant p-values of post hoc comparisons are labeled with one asterisk (*) for p < 0.05 which indicates significant differences between the experimental conditions. Changes of tactile rating are evident for alpha and gamma bands.

Mentions: In the main experiment, repeated measures ANOVA revealed a significant main effect of frequency F(4.34, 47.76) = 4.257, MSE = 0.695, p = 0.004. Post hoc comparisons showed that tACS produced a stronger tactile sensation when tACS was delivered at an alpha frequency (10–14) than at delta (p = 0.015), theta (p = 0.003), mid gamma (p = 0.022). Furthermore, high gamma tACS also induced stronger tactile sensations than delta (p = 0.038) and theta tACS (p = 0.014). Although the effect is weaker, slightly stronger tactile sensation was reported at beta frequency as compared to theta frequency (p = 0.033; Figure 1).


Frequency specific modulation of human somatosensory cortex.

Feurra M, Paulus W, Walsh V, Kanai R - Front Psychol (2011)

Tactile sensation ratings per frequency band. The rating score scaled from 0 (no sensation at all) to 3 (maximum sensation). The error bars correspond to 1 SEM. Conditions with significant p-values of post hoc comparisons are labeled with one asterisk (*) for p < 0.05 which indicates significant differences between the experimental conditions. Changes of tactile rating are evident for alpha and gamma bands.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3111335&req=5

Figure 1: Tactile sensation ratings per frequency band. The rating score scaled from 0 (no sensation at all) to 3 (maximum sensation). The error bars correspond to 1 SEM. Conditions with significant p-values of post hoc comparisons are labeled with one asterisk (*) for p < 0.05 which indicates significant differences between the experimental conditions. Changes of tactile rating are evident for alpha and gamma bands.
Mentions: In the main experiment, repeated measures ANOVA revealed a significant main effect of frequency F(4.34, 47.76) = 4.257, MSE = 0.695, p = 0.004. Post hoc comparisons showed that tACS produced a stronger tactile sensation when tACS was delivered at an alpha frequency (10–14) than at delta (p = 0.015), theta (p = 0.003), mid gamma (p = 0.022). Furthermore, high gamma tACS also induced stronger tactile sensations than delta (p = 0.038) and theta tACS (p = 0.014). Although the effect is weaker, slightly stronger tactile sensation was reported at beta frequency as compared to theta frequency (p = 0.033; Figure 1).

Bottom Line: Oscillatory neuronal activities are commonly observed in response to sensory stimulation.However, their functional roles are still the subject of debate.These findings highlight the frequency dependency of effective tACS over SI with the effective frequencies corresponding to those observed in previous electroencephalography/magnetoencephalography studies of tactile perception.

View Article: PubMed Central - PubMed

Affiliation: Institute of Cognitive Neuroscience, Department of Psychology, University College London London, UK.

ABSTRACT
Oscillatory neuronal activities are commonly observed in response to sensory stimulation. However, their functional roles are still the subject of debate. One-way to probe the roles of oscillatory neural activities is to deliver alternating current to the cortex at biologically relevant frequencies and examine whether such stimulation influences perception and cognition. In this study, we tested whether transcranial alternating current stimulation (tACS) over the primary somatosensory cortex (SI) could elicit tactile sensations in humans in a frequency-dependent manner. We tested the effectiveness of tACS over SI at frequency bands ranging from 2 to 70 Hz. Our results show that stimulation in alpha (10-14 Hz) and high gamma (52-70 Hz) frequency range produces a tactile sensation in the contralateral hand. A weaker effect was also observed for beta (16-20 Hz) stimulation. These findings highlight the frequency dependency of effective tACS over SI with the effective frequencies corresponding to those observed in previous electroencephalography/magnetoencephalography studies of tactile perception. Our present study suggests that tACS could be used as a powerful online stimulation technique to reveal the causal roles of oscillatory brain activities.

No MeSH data available.


Related in: MedlinePlus