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Anti-proliferative activity of meroditerpenoids isolated from the brown alga Stypopodium flabelliforme against several cancer cell lines.

Pereira DM, Cheel J, Areche C, San-Martin A, Rovirosa J, Silva LR, Valentao P, Andrade PB - Mar Drugs (2011)

Bottom Line: In particular, algae have proved to be an interesting source of new bioactive compounds.Antimicrobial capacity was observed for epitaondiol monoacetate, stypotriol triacetate and stypodiol, with the first being the most active.The results suggest that these molecules deserve further studies in order to evaluate their potential as therapeutic agents.

View Article: PubMed Central - PubMed

Affiliation: REQUIMTE/Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, Porto University, R. Anibal Cunha 164, 4050-047 Porto, Portugal.

ABSTRACT
The sea constitutes one of the most promising sources of novel compounds with potential application in human therapeutics. In particular, algae have proved to be an interesting source of new bioactive compounds. In this work, six meroditerpenoids (epitaondiol, epitaondiol diacetate, epitaondiol monoacetate, stypotriol triacetate, 14-ketostypodiol diacetate and stypodiol) isolated from the brown alga Stypopodium flabelliforme were tested for their cell proliferation inhibitory activity in five cell lines. Cell lines tested included human colon adenocarcinoma (Caco-2), human neuroblastoma (SH-SY5Y), rat basophilic leukemia (RBL-2H3), murine macrophages (RAW.267) and Chinese hamster fibroblasts (V79). Antimicrobial activity of the compounds was also evaluated against Staphylococcus aureus, Salmonella typhimurium, Proteus mirabilis, Bacillus cereus, Enterococcus faecalis and Micrococcus luteus. Overall, the compounds showed good activity against all cell lines, with SH-SY5Y and RAW.267 being the most susceptible. Antimicrobial capacity was observed for epitaondiol monoacetate, stypotriol triacetate and stypodiol, with the first being the most active. The results suggest that these molecules deserve further studies in order to evaluate their potential as therapeutic agents.

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Effects of meroditerpenoids on the inhibition of cell proliferation in Caco-2 cells using the SRB assay. Values show mean + SE inhibition, as compared to negative control (0.1% DMSO), from three experiments performed in triplicate. * p < 0.05; ** p < 0.005; *** p < 0.0005.
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f4-marinedrugs-09-00852: Effects of meroditerpenoids on the inhibition of cell proliferation in Caco-2 cells using the SRB assay. Values show mean + SE inhibition, as compared to negative control (0.1% DMSO), from three experiments performed in triplicate. * p < 0.05; ** p < 0.005; *** p < 0.0005.

Mentions: For Caco-2 cell line all compounds showed a concentration-dependent inhibitory effect, with stypotriol triacetate being the most active, followed by epitaondiol monoacetate and epitaondiol (Figure 4). A similar trend was found regarding RBL-2H3 cell line (Figure 5).


Anti-proliferative activity of meroditerpenoids isolated from the brown alga Stypopodium flabelliforme against several cancer cell lines.

Pereira DM, Cheel J, Areche C, San-Martin A, Rovirosa J, Silva LR, Valentao P, Andrade PB - Mar Drugs (2011)

Effects of meroditerpenoids on the inhibition of cell proliferation in Caco-2 cells using the SRB assay. Values show mean + SE inhibition, as compared to negative control (0.1% DMSO), from three experiments performed in triplicate. * p < 0.05; ** p < 0.005; *** p < 0.0005.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3111187&req=5

f4-marinedrugs-09-00852: Effects of meroditerpenoids on the inhibition of cell proliferation in Caco-2 cells using the SRB assay. Values show mean + SE inhibition, as compared to negative control (0.1% DMSO), from three experiments performed in triplicate. * p < 0.05; ** p < 0.005; *** p < 0.0005.
Mentions: For Caco-2 cell line all compounds showed a concentration-dependent inhibitory effect, with stypotriol triacetate being the most active, followed by epitaondiol monoacetate and epitaondiol (Figure 4). A similar trend was found regarding RBL-2H3 cell line (Figure 5).

Bottom Line: In particular, algae have proved to be an interesting source of new bioactive compounds.Antimicrobial capacity was observed for epitaondiol monoacetate, stypotriol triacetate and stypodiol, with the first being the most active.The results suggest that these molecules deserve further studies in order to evaluate their potential as therapeutic agents.

View Article: PubMed Central - PubMed

Affiliation: REQUIMTE/Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, Porto University, R. Anibal Cunha 164, 4050-047 Porto, Portugal.

ABSTRACT
The sea constitutes one of the most promising sources of novel compounds with potential application in human therapeutics. In particular, algae have proved to be an interesting source of new bioactive compounds. In this work, six meroditerpenoids (epitaondiol, epitaondiol diacetate, epitaondiol monoacetate, stypotriol triacetate, 14-ketostypodiol diacetate and stypodiol) isolated from the brown alga Stypopodium flabelliforme were tested for their cell proliferation inhibitory activity in five cell lines. Cell lines tested included human colon adenocarcinoma (Caco-2), human neuroblastoma (SH-SY5Y), rat basophilic leukemia (RBL-2H3), murine macrophages (RAW.267) and Chinese hamster fibroblasts (V79). Antimicrobial activity of the compounds was also evaluated against Staphylococcus aureus, Salmonella typhimurium, Proteus mirabilis, Bacillus cereus, Enterococcus faecalis and Micrococcus luteus. Overall, the compounds showed good activity against all cell lines, with SH-SY5Y and RAW.267 being the most susceptible. Antimicrobial capacity was observed for epitaondiol monoacetate, stypotriol triacetate and stypodiol, with the first being the most active. The results suggest that these molecules deserve further studies in order to evaluate their potential as therapeutic agents.

Show MeSH
Related in: MedlinePlus