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Anti-proliferative activity of meroditerpenoids isolated from the brown alga Stypopodium flabelliforme against several cancer cell lines.

Pereira DM, Cheel J, Areche C, San-Martin A, Rovirosa J, Silva LR, Valentao P, Andrade PB - Mar Drugs (2011)

Bottom Line: In particular, algae have proved to be an interesting source of new bioactive compounds.Antimicrobial capacity was observed for epitaondiol monoacetate, stypotriol triacetate and stypodiol, with the first being the most active.The results suggest that these molecules deserve further studies in order to evaluate their potential as therapeutic agents.

View Article: PubMed Central - PubMed

Affiliation: REQUIMTE/Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, Porto University, R. Anibal Cunha 164, 4050-047 Porto, Portugal.

ABSTRACT
The sea constitutes one of the most promising sources of novel compounds with potential application in human therapeutics. In particular, algae have proved to be an interesting source of new bioactive compounds. In this work, six meroditerpenoids (epitaondiol, epitaondiol diacetate, epitaondiol monoacetate, stypotriol triacetate, 14-ketostypodiol diacetate and stypodiol) isolated from the brown alga Stypopodium flabelliforme were tested for their cell proliferation inhibitory activity in five cell lines. Cell lines tested included human colon adenocarcinoma (Caco-2), human neuroblastoma (SH-SY5Y), rat basophilic leukemia (RBL-2H3), murine macrophages (RAW.267) and Chinese hamster fibroblasts (V79). Antimicrobial activity of the compounds was also evaluated against Staphylococcus aureus, Salmonella typhimurium, Proteus mirabilis, Bacillus cereus, Enterococcus faecalis and Micrococcus luteus. Overall, the compounds showed good activity against all cell lines, with SH-SY5Y and RAW.267 being the most susceptible. Antimicrobial capacity was observed for epitaondiol monoacetate, stypotriol triacetate and stypodiol, with the first being the most active. The results suggest that these molecules deserve further studies in order to evaluate their potential as therapeutic agents.

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Structures of the meroditerpenoids evaluated in this study.
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f1-marinedrugs-09-00852: Structures of the meroditerpenoids evaluated in this study.

Mentions: Due to the increasing prevalence and incidence of cancer in both developing and developed countries, new molecules to be used in cancer chemotherapy are needed. In this work, six meroditerpenoids (epitaondiol, epitaondiol diacetate, epitaondiol monoacetate, stypotriol triacetate, 14-ketostypodiol diacetate and stypodiol) (Figure 1) isolated from the brown alga Stypopodium flabelliforme were tested for their anti-proliferative properties against the cancer cell lines SH-SY5Y (human neuroblastoma), Caco-2 (human colorectal adenocarcinoma), RBL-2H3 (rat basophilic leukemia) and RAW.267 (mouse macrophages) and towards V79 non-cancer cell line (Chinese hamster fibroblasts). Few studies have addressed the potential biological activities of the meroditerpenoids studied herein. Soares et al. described the activity of epitaondiol against herpes simplex virus [8]. Epitaondiol diacetate was studied for its pharmacological effects in rat cardiovascular system and a negative inotropic effect of 35% was observed. A negative chronotropic effect was also noticed [9]. Epitaondiol and stypotriol triacetate revealed marked anti-inflammatory activities via decreased secretion of eicosanoids and modulation of the cyclooxigenase pathway through inhibition of some key enzymes, such as phospholipase A2, as assayed using [3H]oleate-labeled membranes of Escherichia coli [10].


Anti-proliferative activity of meroditerpenoids isolated from the brown alga Stypopodium flabelliforme against several cancer cell lines.

Pereira DM, Cheel J, Areche C, San-Martin A, Rovirosa J, Silva LR, Valentao P, Andrade PB - Mar Drugs (2011)

Structures of the meroditerpenoids evaluated in this study.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3111187&req=5

f1-marinedrugs-09-00852: Structures of the meroditerpenoids evaluated in this study.
Mentions: Due to the increasing prevalence and incidence of cancer in both developing and developed countries, new molecules to be used in cancer chemotherapy are needed. In this work, six meroditerpenoids (epitaondiol, epitaondiol diacetate, epitaondiol monoacetate, stypotriol triacetate, 14-ketostypodiol diacetate and stypodiol) (Figure 1) isolated from the brown alga Stypopodium flabelliforme were tested for their anti-proliferative properties against the cancer cell lines SH-SY5Y (human neuroblastoma), Caco-2 (human colorectal adenocarcinoma), RBL-2H3 (rat basophilic leukemia) and RAW.267 (mouse macrophages) and towards V79 non-cancer cell line (Chinese hamster fibroblasts). Few studies have addressed the potential biological activities of the meroditerpenoids studied herein. Soares et al. described the activity of epitaondiol against herpes simplex virus [8]. Epitaondiol diacetate was studied for its pharmacological effects in rat cardiovascular system and a negative inotropic effect of 35% was observed. A negative chronotropic effect was also noticed [9]. Epitaondiol and stypotriol triacetate revealed marked anti-inflammatory activities via decreased secretion of eicosanoids and modulation of the cyclooxigenase pathway through inhibition of some key enzymes, such as phospholipase A2, as assayed using [3H]oleate-labeled membranes of Escherichia coli [10].

Bottom Line: In particular, algae have proved to be an interesting source of new bioactive compounds.Antimicrobial capacity was observed for epitaondiol monoacetate, stypotriol triacetate and stypodiol, with the first being the most active.The results suggest that these molecules deserve further studies in order to evaluate their potential as therapeutic agents.

View Article: PubMed Central - PubMed

Affiliation: REQUIMTE/Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, Porto University, R. Anibal Cunha 164, 4050-047 Porto, Portugal.

ABSTRACT
The sea constitutes one of the most promising sources of novel compounds with potential application in human therapeutics. In particular, algae have proved to be an interesting source of new bioactive compounds. In this work, six meroditerpenoids (epitaondiol, epitaondiol diacetate, epitaondiol monoacetate, stypotriol triacetate, 14-ketostypodiol diacetate and stypodiol) isolated from the brown alga Stypopodium flabelliforme were tested for their cell proliferation inhibitory activity in five cell lines. Cell lines tested included human colon adenocarcinoma (Caco-2), human neuroblastoma (SH-SY5Y), rat basophilic leukemia (RBL-2H3), murine macrophages (RAW.267) and Chinese hamster fibroblasts (V79). Antimicrobial activity of the compounds was also evaluated against Staphylococcus aureus, Salmonella typhimurium, Proteus mirabilis, Bacillus cereus, Enterococcus faecalis and Micrococcus luteus. Overall, the compounds showed good activity against all cell lines, with SH-SY5Y and RAW.267 being the most susceptible. Antimicrobial capacity was observed for epitaondiol monoacetate, stypotriol triacetate and stypodiol, with the first being the most active. The results suggest that these molecules deserve further studies in order to evaluate their potential as therapeutic agents.

Show MeSH
Related in: MedlinePlus