Limits...
Three bianthraquinone derivatives from the mangrove endophytic fungus Alternaria sp. ZJ9-6B from the South China Sea.

Huang CH, Pan JH, Chen B, Yu M, Huang HB, Zhu X, Lu YJ, She ZG, Lin YC - Mar Drugs (2011)

Bottom Line: Their structures were elucidated by one- and two-dimensional NMR spectroscopy, MS data analysis and circular dichroism measurements.Compounds 1, 2 and 3 were first isolated alterporriols with a C-2-C-2' linkage.The crystallographic data of tetrahydroaltersolanol B (7) was reported for the first time.

View Article: PubMed Central - PubMed

Affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.

ABSTRACT
Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea. Their structures were elucidated by one- and two-dimensional NMR spectroscopy, MS data analysis and circular dichroism measurements. Compounds 1, 2 and 3 were first isolated alterporriols with a C-2-C-2' linkage. The crystallographic data of tetrahydroaltersolanol B (7) was reported for the first time. In the primary bioassays, alterporriol K and L exhibited moderate cytotoxic activity towards MDA-MB-435 and MCF-7 cells with IC₅₀ values ranging from 13.1 to 29.1 μM.

Show MeSH

Related in: MedlinePlus

Structures of 1–9 isolated from Alternaria sp. ZJ9-6B.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC3111185&req=5

f1-marinedrugs-09-00832: Structures of 1–9 isolated from Alternaria sp. ZJ9-6B.

Mentions: As part of our ongoing program to search for new bioactive natural products from the South China Sea [14–16], an endophytic fungus Alternaria sp. ZJ9-6B has been isolated from the fruit of the marine mangrove Aegiceras corniculatum in Zhanjiang, Guangdong, China. Chemical investigation of this fungus led to the isolation of nine metabolites, including three new anthraquinone derivatives 1–3 and six known compounds 4–9 (Figure 1). It is interesting that compounds 1–3 all possess dimeric structures with a C-2–C-2′ linkage. In this report, we describe the isolation, structural elucidation and biological activity of these new metabolites.


Three bianthraquinone derivatives from the mangrove endophytic fungus Alternaria sp. ZJ9-6B from the South China Sea.

Huang CH, Pan JH, Chen B, Yu M, Huang HB, Zhu X, Lu YJ, She ZG, Lin YC - Mar Drugs (2011)

Structures of 1–9 isolated from Alternaria sp. ZJ9-6B.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3111185&req=5

f1-marinedrugs-09-00832: Structures of 1–9 isolated from Alternaria sp. ZJ9-6B.
Mentions: As part of our ongoing program to search for new bioactive natural products from the South China Sea [14–16], an endophytic fungus Alternaria sp. ZJ9-6B has been isolated from the fruit of the marine mangrove Aegiceras corniculatum in Zhanjiang, Guangdong, China. Chemical investigation of this fungus led to the isolation of nine metabolites, including three new anthraquinone derivatives 1–3 and six known compounds 4–9 (Figure 1). It is interesting that compounds 1–3 all possess dimeric structures with a C-2–C-2′ linkage. In this report, we describe the isolation, structural elucidation and biological activity of these new metabolites.

Bottom Line: Their structures were elucidated by one- and two-dimensional NMR spectroscopy, MS data analysis and circular dichroism measurements.Compounds 1, 2 and 3 were first isolated alterporriols with a C-2-C-2' linkage.The crystallographic data of tetrahydroaltersolanol B (7) was reported for the first time.

View Article: PubMed Central - PubMed

Affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.

ABSTRACT
Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea. Their structures were elucidated by one- and two-dimensional NMR spectroscopy, MS data analysis and circular dichroism measurements. Compounds 1, 2 and 3 were first isolated alterporriols with a C-2-C-2' linkage. The crystallographic data of tetrahydroaltersolanol B (7) was reported for the first time. In the primary bioassays, alterporriol K and L exhibited moderate cytotoxic activity towards MDA-MB-435 and MCF-7 cells with IC₅₀ values ranging from 13.1 to 29.1 μM.

Show MeSH
Related in: MedlinePlus