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Soluble CD163: A novel biomarker for the susceptibility to sepsis in severe burn injuries.

Piatkowski A, Grieb G, Das R, Bozkurt A, Ulrich D, Pallua N - Indian J Plast Surg (2011)

Bottom Line: Soluble CD163 (sCD163) has been previously shown to play a role in inflammatory and infectious diseases.Statistical analysis was performed using the Mann-Whitney test, Wilcoxon signed rank and Pearson bivariate correlation.The first view on the characteristics of sCD163 in the serum of burn patients points out that sCD163 seems to be an early indicator for the susceptibility to sepsis.

View Article: PubMed Central - PubMed

Affiliation: Department of Plastic Surgery and Hand Surgery, Burn Unit of the RWTH University Hospital in Aachen, Germany.

ABSTRACT

Objective: Soluble CD163 (sCD163) has been previously shown to play a role in inflammatory and infectious diseases. This study, for the first time, investigates the characteristics and potential values of sCD163 in burn patients. A first look is taken on the changes of sCD163 levels in burn patients by comparing predefined subgroups at single time points.

Materials and methods: Serum samples of 18 patients with burn injuries were collected for biochemical analysis at the time of admission and in a chronological sequence of 12, 24, 48 and 120 h after the injury and were matched to clinical parameters. Statistical analysis was performed using the Mann-Whitney test, Wilcoxon signed rank and Pearson bivariate correlation.

Results: Patients with sepsis showed a significant increase of sCD163 levels. sCD163 was correlated with leukocytes (P=0.035) over the time course of 120 h. Patients characterized by a burn size exceeding 25% of the total body surface area (TBSA) showed a significant increase of sCD163 between 12 and 48 h after burn injury (P=0.038).

Conclusions: The first view on the characteristics of sCD163 in the serum of burn patients points out that sCD163 seems to be an early indicator for the susceptibility to sepsis. Furthermore, the changes in sCD163 serum levels within the first hours after burn trauma have great potential for early prediction of organ failure after burn injury.

No MeSH data available.


Related in: MedlinePlus

Serum levels of sCD163 (L) in patients with burn trauma in relation to the peak of the SOFA score within the first 120 h after the burn injury. Group A burn patients with a SOFA score (n=10) from 0 to 10 points in comparison with group B patients with a SOFA score of 11 points or more (n=8). Statistical significant differences between groups (Mann-Whitney test) and time points (Wilcoxon signed rank) are labelled under specification of the level of significance
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Figure 6: Serum levels of sCD163 (L) in patients with burn trauma in relation to the peak of the SOFA score within the first 120 h after the burn injury. Group A burn patients with a SOFA score (n=10) from 0 to 10 points in comparison with group B patients with a SOFA score of 11 points or more (n=8). Statistical significant differences between groups (Mann-Whitney test) and time points (Wilcoxon signed rank) are labelled under specification of the level of significance

Mentions: Burn patients with a SOFA score from 0 to 10 points within the first 120 h after the injury (group A; n=10) showed a significant decrease of sCD163 levels between 12 and 24 h after burn trauma. In contrast, patients with a SOFA-score of 11 points or more (n=8) showed a significant increase of sCD163 levels between the time points 12 and 120 h after admission [Figure 6 and Table 2]. In order to confirm our hypothesis that higher SOFA scores involve high sCD163 levels, we performed a Spearman rank order correlation, which revealed a positive correlation between SOFA scores and sCD163 levels (P<0.05; r= -0.232).


Soluble CD163: A novel biomarker for the susceptibility to sepsis in severe burn injuries.

Piatkowski A, Grieb G, Das R, Bozkurt A, Ulrich D, Pallua N - Indian J Plast Surg (2011)

Serum levels of sCD163 (L) in patients with burn trauma in relation to the peak of the SOFA score within the first 120 h after the burn injury. Group A burn patients with a SOFA score (n=10) from 0 to 10 points in comparison with group B patients with a SOFA score of 11 points or more (n=8). Statistical significant differences between groups (Mann-Whitney test) and time points (Wilcoxon signed rank) are labelled under specification of the level of significance
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3111102&req=5

Figure 6: Serum levels of sCD163 (L) in patients with burn trauma in relation to the peak of the SOFA score within the first 120 h after the burn injury. Group A burn patients with a SOFA score (n=10) from 0 to 10 points in comparison with group B patients with a SOFA score of 11 points or more (n=8). Statistical significant differences between groups (Mann-Whitney test) and time points (Wilcoxon signed rank) are labelled under specification of the level of significance
Mentions: Burn patients with a SOFA score from 0 to 10 points within the first 120 h after the injury (group A; n=10) showed a significant decrease of sCD163 levels between 12 and 24 h after burn trauma. In contrast, patients with a SOFA-score of 11 points or more (n=8) showed a significant increase of sCD163 levels between the time points 12 and 120 h after admission [Figure 6 and Table 2]. In order to confirm our hypothesis that higher SOFA scores involve high sCD163 levels, we performed a Spearman rank order correlation, which revealed a positive correlation between SOFA scores and sCD163 levels (P<0.05; r= -0.232).

Bottom Line: Soluble CD163 (sCD163) has been previously shown to play a role in inflammatory and infectious diseases.Statistical analysis was performed using the Mann-Whitney test, Wilcoxon signed rank and Pearson bivariate correlation.The first view on the characteristics of sCD163 in the serum of burn patients points out that sCD163 seems to be an early indicator for the susceptibility to sepsis.

View Article: PubMed Central - PubMed

Affiliation: Department of Plastic Surgery and Hand Surgery, Burn Unit of the RWTH University Hospital in Aachen, Germany.

ABSTRACT

Objective: Soluble CD163 (sCD163) has been previously shown to play a role in inflammatory and infectious diseases. This study, for the first time, investigates the characteristics and potential values of sCD163 in burn patients. A first look is taken on the changes of sCD163 levels in burn patients by comparing predefined subgroups at single time points.

Materials and methods: Serum samples of 18 patients with burn injuries were collected for biochemical analysis at the time of admission and in a chronological sequence of 12, 24, 48 and 120 h after the injury and were matched to clinical parameters. Statistical analysis was performed using the Mann-Whitney test, Wilcoxon signed rank and Pearson bivariate correlation.

Results: Patients with sepsis showed a significant increase of sCD163 levels. sCD163 was correlated with leukocytes (P=0.035) over the time course of 120 h. Patients characterized by a burn size exceeding 25% of the total body surface area (TBSA) showed a significant increase of sCD163 between 12 and 48 h after burn injury (P=0.038).

Conclusions: The first view on the characteristics of sCD163 in the serum of burn patients points out that sCD163 seems to be an early indicator for the susceptibility to sepsis. Furthermore, the changes in sCD163 serum levels within the first hours after burn trauma have great potential for early prediction of organ failure after burn injury.

No MeSH data available.


Related in: MedlinePlus