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Evaluations of bacterial contaminated full thickness burn wound healing in Sprague Dawley rats Treated with Tualang honey.

Sukur SM, Halim AS, Singh KK - Indian J Plast Surg (2011)

Bottom Line: The mean wound size of the Tualang honey-treated wounds was not statistically different than that of the Chitosan gel or Hydrofibre silver-treated wounds when the wounds were compared throughout the entire experiment (P > 0.05).However, comparing the mean wound size on day 21 alone revealed that the Tualang honey-treated wounds were smaller in comparison to that of the Chitosan gel and Hydrofibre silver-treated groups.This study shows that topical application of Tualang honey on burn wounds contaminated with P. aeruginosa and A. baumannii gave the fastest rate of healing compared with other treatments.

View Article: PubMed Central - PubMed

Affiliation: Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, Malaysia.

ABSTRACT

Aim: The effect of Tualang honey on wound healing in bacterial contaminated full-thickness burn wounds was evaluated in 36 male Sprague Dawley rats.

Materials and methods: The rats were randomly divided into three groups (n = 12/group). Three full-thickness burn wounds were created on each rat. Each group of rats was inoculated with a different organism in the burn wounds: Group A was inoculated with Pseudomonas aeruginosa, Group B was inoculated with Klebsiella pneumoniae and Group C was inoculated with Acinetobacter baumannii. One wound on each rat was dressed with either Tualang honey, Chitosan gel or Hydrofibre silver. Each wound size was measured on day 3, 6, 9, 12, 15, 18 and 21 of the study.

Results: The mean wound size of the Tualang honey-treated wounds was not statistically different than that of the Chitosan gel or Hydrofibre silver-treated wounds when the wounds were compared throughout the entire experiment (P > 0.05). However, comparing the mean wound size on day 21 alone revealed that the Tualang honey-treated wounds were smaller in comparison to that of the Chitosan gel and Hydrofibre silver-treated groups.

Conclusions: This study shows that topical application of Tualang honey on burn wounds contaminated with P. aeruginosa and A. baumannii gave the fastest rate of healing compared with other treatments.

No MeSH data available.


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Wound size measurement in rats inoculated with Klebsiella pneumoniae (Group B)
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Figure 2: Wound size measurement in rats inoculated with Klebsiella pneumoniae (Group B)

Mentions: In Group B, there was a 47% reduction in wound size by day 9 (P = 0.019) in the Tualang honey-treated wounds, and however increased by 106% by day 12 (P = 0.056) and 24% by day 15 (P = 0.997). The wounds remained larger for the Tualang honey-treated wounds than in the Chitosan gel and Hydrofibre silver-treated wounds by day 18 (P = 0.852) and day 21 (P = 0.874). There was no significant difference among the three treatments at day 6, 12, 15, 18 or 21 except day 3 and 9. The mean wound size of Tualang honey-treated wounds and other treated wounds increased at day 12 because of significant inflammation from K. pneumoniae infection and then gradually decreased after day 15 [Table 2 and Figure 2].


Evaluations of bacterial contaminated full thickness burn wound healing in Sprague Dawley rats Treated with Tualang honey.

Sukur SM, Halim AS, Singh KK - Indian J Plast Surg (2011)

Wound size measurement in rats inoculated with Klebsiella pneumoniae (Group B)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3111101&req=5

Figure 2: Wound size measurement in rats inoculated with Klebsiella pneumoniae (Group B)
Mentions: In Group B, there was a 47% reduction in wound size by day 9 (P = 0.019) in the Tualang honey-treated wounds, and however increased by 106% by day 12 (P = 0.056) and 24% by day 15 (P = 0.997). The wounds remained larger for the Tualang honey-treated wounds than in the Chitosan gel and Hydrofibre silver-treated wounds by day 18 (P = 0.852) and day 21 (P = 0.874). There was no significant difference among the three treatments at day 6, 12, 15, 18 or 21 except day 3 and 9. The mean wound size of Tualang honey-treated wounds and other treated wounds increased at day 12 because of significant inflammation from K. pneumoniae infection and then gradually decreased after day 15 [Table 2 and Figure 2].

Bottom Line: The mean wound size of the Tualang honey-treated wounds was not statistically different than that of the Chitosan gel or Hydrofibre silver-treated wounds when the wounds were compared throughout the entire experiment (P > 0.05).However, comparing the mean wound size on day 21 alone revealed that the Tualang honey-treated wounds were smaller in comparison to that of the Chitosan gel and Hydrofibre silver-treated groups.This study shows that topical application of Tualang honey on burn wounds contaminated with P. aeruginosa and A. baumannii gave the fastest rate of healing compared with other treatments.

View Article: PubMed Central - PubMed

Affiliation: Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, Malaysia.

ABSTRACT

Aim: The effect of Tualang honey on wound healing in bacterial contaminated full-thickness burn wounds was evaluated in 36 male Sprague Dawley rats.

Materials and methods: The rats were randomly divided into three groups (n = 12/group). Three full-thickness burn wounds were created on each rat. Each group of rats was inoculated with a different organism in the burn wounds: Group A was inoculated with Pseudomonas aeruginosa, Group B was inoculated with Klebsiella pneumoniae and Group C was inoculated with Acinetobacter baumannii. One wound on each rat was dressed with either Tualang honey, Chitosan gel or Hydrofibre silver. Each wound size was measured on day 3, 6, 9, 12, 15, 18 and 21 of the study.

Results: The mean wound size of the Tualang honey-treated wounds was not statistically different than that of the Chitosan gel or Hydrofibre silver-treated wounds when the wounds were compared throughout the entire experiment (P > 0.05). However, comparing the mean wound size on day 21 alone revealed that the Tualang honey-treated wounds were smaller in comparison to that of the Chitosan gel and Hydrofibre silver-treated groups.

Conclusions: This study shows that topical application of Tualang honey on burn wounds contaminated with P. aeruginosa and A. baumannii gave the fastest rate of healing compared with other treatments.

No MeSH data available.


Related in: MedlinePlus