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A case of monoclonal gammopathy in extranodal marginal zone B-cell lymphoma of the small intestine.

Kim do Y, Kim YS, Huh HJ, Choi JS, Yeo JS, Kwak BS, Chae SL - Korean J Lab Med (2011)

Bottom Line: Monoclonal gammopathy occurs in one-third of the patients with mucosa-associated lymphoid tissue lymphoma (MALT lymphoma).Paraprotenemia accompanying MALT lymphoma is strongly correlated with involvement of the bone marrow, and this involvement leads to the progression of the disease.Here, we present a case of a 66-yr-old man diagnosed with IgM monoclonal gammopathy and stage IV extranodal marginal zone lymphoma of the small intestine, with the involvement of the bone marrow.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, College of Medicine, Dongguk University Ilsan Hospital, Goyang, Korea.

ABSTRACT
Monoclonal gammopathy occurs in one-third of the patients with mucosa-associated lymphoid tissue lymphoma (MALT lymphoma). However, monoclonal gammopathy has been rarely reported in Korea. Paraprotenemia accompanying MALT lymphoma is strongly correlated with involvement of the bone marrow, and this involvement leads to the progression of the disease. Here, we present a case of a 66-yr-old man diagnosed with IgM monoclonal gammopathy and stage IV extranodal marginal zone lymphoma of the small intestine, with the involvement of the bone marrow.

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Findings of peripheral blood smear and bone marrow study. (A) The peripheral blood smear shows a plasmacytoid lymphocyte (Wright stain, ×1,000). (B) The bone marrow aspirate contains 2.1% plasma cells (Wright stain, ×1,000). (C) Bone marrow biopsy showing interstitial infiltration of mature lymphocytes (hematoxylin and eosin stain, ×400).
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Figure 3: Findings of peripheral blood smear and bone marrow study. (A) The peripheral blood smear shows a plasmacytoid lymphocyte (Wright stain, ×1,000). (B) The bone marrow aspirate contains 2.1% plasma cells (Wright stain, ×1,000). (C) Bone marrow biopsy showing interstitial infiltration of mature lymphocytes (hematoxylin and eosin stain, ×400).

Mentions: Bone marrow biopsy was performed, which showed bone marrow involvement of ENMZL. The bone marrow aspirate showed 20% cellularity and 2.1% of plasma cells (Fig. 3B). Bone marrow biopsy revealed focal infiltration of the neoplastic lymphoid cells, which showed a morphologic spectrum, including small lymphocytes with inconspicuous nucleoli and plasmacytoid lymphocytes (Fig. 3C).


A case of monoclonal gammopathy in extranodal marginal zone B-cell lymphoma of the small intestine.

Kim do Y, Kim YS, Huh HJ, Choi JS, Yeo JS, Kwak BS, Chae SL - Korean J Lab Med (2011)

Findings of peripheral blood smear and bone marrow study. (A) The peripheral blood smear shows a plasmacytoid lymphocyte (Wright stain, ×1,000). (B) The bone marrow aspirate contains 2.1% plasma cells (Wright stain, ×1,000). (C) Bone marrow biopsy showing interstitial infiltration of mature lymphocytes (hematoxylin and eosin stain, ×400).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3111039&req=5

Figure 3: Findings of peripheral blood smear and bone marrow study. (A) The peripheral blood smear shows a plasmacytoid lymphocyte (Wright stain, ×1,000). (B) The bone marrow aspirate contains 2.1% plasma cells (Wright stain, ×1,000). (C) Bone marrow biopsy showing interstitial infiltration of mature lymphocytes (hematoxylin and eosin stain, ×400).
Mentions: Bone marrow biopsy was performed, which showed bone marrow involvement of ENMZL. The bone marrow aspirate showed 20% cellularity and 2.1% of plasma cells (Fig. 3B). Bone marrow biopsy revealed focal infiltration of the neoplastic lymphoid cells, which showed a morphologic spectrum, including small lymphocytes with inconspicuous nucleoli and plasmacytoid lymphocytes (Fig. 3C).

Bottom Line: Monoclonal gammopathy occurs in one-third of the patients with mucosa-associated lymphoid tissue lymphoma (MALT lymphoma).Paraprotenemia accompanying MALT lymphoma is strongly correlated with involvement of the bone marrow, and this involvement leads to the progression of the disease.Here, we present a case of a 66-yr-old man diagnosed with IgM monoclonal gammopathy and stage IV extranodal marginal zone lymphoma of the small intestine, with the involvement of the bone marrow.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, College of Medicine, Dongguk University Ilsan Hospital, Goyang, Korea.

ABSTRACT
Monoclonal gammopathy occurs in one-third of the patients with mucosa-associated lymphoid tissue lymphoma (MALT lymphoma). However, monoclonal gammopathy has been rarely reported in Korea. Paraprotenemia accompanying MALT lymphoma is strongly correlated with involvement of the bone marrow, and this involvement leads to the progression of the disease. Here, we present a case of a 66-yr-old man diagnosed with IgM monoclonal gammopathy and stage IV extranodal marginal zone lymphoma of the small intestine, with the involvement of the bone marrow.

Show MeSH
Related in: MedlinePlus