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A parametric study delineating irreversible electroporation from thermal damage based on a minimally invasive intracranial procedure.

Garcia PA, Rossmeisl JH, Neal RE, Ellis TL, Davalos RV - Biomed Eng Online (2011)

Bottom Line: We developed numerical simulations of typical protocols based on a previously published computed tomographic (CT) guided in vivo procedure.We confirm that determining an IRE treatment protocol requires incorporating all the physical effects of electroporation, and that these effects may have significant implications in treatment planning and outcome assessment.The goal of the manuscript is to provide the reader with the numerical methods to assess multiple-pulse electroporation treatment protocols in order to isolate IRE from thermal damage and capitalize on the benefits of a non-thermal mode of tissue ablation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Bioelectromechanical Systems Laboratory, School of Biomedical Engineering and Sciences, Virginia Tech-Wake Forest University, Blacksburg, VA, USA.

ABSTRACT

Background: Irreversible electroporation (IRE) is a new minimally invasive technique to kill undesirable tissue in a non-thermal manner. In order to maximize the benefits from an IRE procedure, the pulse parameters and electrode configuration must be optimized to achieve complete coverage of the targeted tissue while preventing thermal damage due to excessive Joule heating.

Methods: We developed numerical simulations of typical protocols based on a previously published computed tomographic (CT) guided in vivo procedure. These models were adapted to assess the effects of temperature, electroporation, pulse duration, and repetition rate on the volumes of tissue undergoing IRE alone or in superposition with thermal damage.

Results: Nine different combinations of voltage and pulse frequency were investigated, five of which resulted in IRE alone while four produced IRE in superposition with thermal damage.

Conclusions: The parametric study evaluated the influence of pulse frequency and applied voltage on treatment volumes, and refined a proposed method to delineate IRE from thermal damage. We confirm that determining an IRE treatment protocol requires incorporating all the physical effects of electroporation, and that these effects may have significant implications in treatment planning and outcome assessment. The goal of the manuscript is to provide the reader with the numerical methods to assess multiple-pulse electroporation treatment protocols in order to isolate IRE from thermal damage and capitalize on the benefits of a non-thermal mode of tissue ablation.

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Reconstructed computed tomographic (CT) scans confirming the placement of the electrodes. The electrodes were placed into the targeted deep white matter of the corpus callosum of a canine prior to the delivery of the IRE pulses. The procedure was performed in a minimally invasive fashion through 1.2 mm diameter burr holes.
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Figure 1: Reconstructed computed tomographic (CT) scans confirming the placement of the electrodes. The electrodes were placed into the targeted deep white matter of the corpus callosum of a canine prior to the delivery of the IRE pulses. The procedure was performed in a minimally invasive fashion through 1.2 mm diameter burr holes.

Mentions: The experimental aspect of the study is described in detail within our previously published conference proceeding [23], and was approved by the Institutional Animal Care and Use Committee and performed in a Good Laboratory Practices (GLP) compliant facility. After induction of general anesthesia in the canine, two 1.2 mm diameter burr holes were created in the skull in preparation for electrode insertion [23]. The CT guidance system was used to place the electrodes into the targeted deep white matter of the corpus callosum, as seen in Figure 1 (TeraRecon, Foster City, CA) [23].


A parametric study delineating irreversible electroporation from thermal damage based on a minimally invasive intracranial procedure.

Garcia PA, Rossmeisl JH, Neal RE, Ellis TL, Davalos RV - Biomed Eng Online (2011)

Reconstructed computed tomographic (CT) scans confirming the placement of the electrodes. The electrodes were placed into the targeted deep white matter of the corpus callosum of a canine prior to the delivery of the IRE pulses. The procedure was performed in a minimally invasive fashion through 1.2 mm diameter burr holes.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108916&req=5

Figure 1: Reconstructed computed tomographic (CT) scans confirming the placement of the electrodes. The electrodes were placed into the targeted deep white matter of the corpus callosum of a canine prior to the delivery of the IRE pulses. The procedure was performed in a minimally invasive fashion through 1.2 mm diameter burr holes.
Mentions: The experimental aspect of the study is described in detail within our previously published conference proceeding [23], and was approved by the Institutional Animal Care and Use Committee and performed in a Good Laboratory Practices (GLP) compliant facility. After induction of general anesthesia in the canine, two 1.2 mm diameter burr holes were created in the skull in preparation for electrode insertion [23]. The CT guidance system was used to place the electrodes into the targeted deep white matter of the corpus callosum, as seen in Figure 1 (TeraRecon, Foster City, CA) [23].

Bottom Line: We developed numerical simulations of typical protocols based on a previously published computed tomographic (CT) guided in vivo procedure.We confirm that determining an IRE treatment protocol requires incorporating all the physical effects of electroporation, and that these effects may have significant implications in treatment planning and outcome assessment.The goal of the manuscript is to provide the reader with the numerical methods to assess multiple-pulse electroporation treatment protocols in order to isolate IRE from thermal damage and capitalize on the benefits of a non-thermal mode of tissue ablation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Bioelectromechanical Systems Laboratory, School of Biomedical Engineering and Sciences, Virginia Tech-Wake Forest University, Blacksburg, VA, USA.

ABSTRACT

Background: Irreversible electroporation (IRE) is a new minimally invasive technique to kill undesirable tissue in a non-thermal manner. In order to maximize the benefits from an IRE procedure, the pulse parameters and electrode configuration must be optimized to achieve complete coverage of the targeted tissue while preventing thermal damage due to excessive Joule heating.

Methods: We developed numerical simulations of typical protocols based on a previously published computed tomographic (CT) guided in vivo procedure. These models were adapted to assess the effects of temperature, electroporation, pulse duration, and repetition rate on the volumes of tissue undergoing IRE alone or in superposition with thermal damage.

Results: Nine different combinations of voltage and pulse frequency were investigated, five of which resulted in IRE alone while four produced IRE in superposition with thermal damage.

Conclusions: The parametric study evaluated the influence of pulse frequency and applied voltage on treatment volumes, and refined a proposed method to delineate IRE from thermal damage. We confirm that determining an IRE treatment protocol requires incorporating all the physical effects of electroporation, and that these effects may have significant implications in treatment planning and outcome assessment. The goal of the manuscript is to provide the reader with the numerical methods to assess multiple-pulse electroporation treatment protocols in order to isolate IRE from thermal damage and capitalize on the benefits of a non-thermal mode of tissue ablation.

Show MeSH
Related in: MedlinePlus