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Serum levels of Th17-related cytokines in Behcet disease patients after cataract surgery.

Jiang S, Liu X, Luo L, Qu B, Huang X, Lin Y, Ye S, Liu Y - Mol. Vis. (2011)

Bottom Line: In the BD patients, serum levels of IFN-γ and IL-27 correlated strongly with aqueous flare values and cell counts.Remarkably, the levels of serum IL-27 were significantly associated with serum IFN-γ levels in BD patients (r=0.796; p=0.002).Our data indicates that serum IFN-γ and IL-27 levels are significantly elevated in BD versus control patients and are strongly associated with post-operative intraocular inflammation.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

ABSTRACT

Purpose: To investigate the profile of T-helper type 17 (Th17) cell-related cytokines (interleukin-23 [IL-23], IL-27, IL-17 and interferon-γ [IFN-γ]) in postoperative inflammation in patients with Behcet disease (BD) after cataract surgery.

Methods: Serum was collected from seven BD patients with complicated cataract, and from nine controls with uncomplicated cataract, before cataract surgery, and again 1, 7, 30, and 90 days after surgery. In addition, aqueous humor was collected at commencement of surgery. The protein levels of IL-23, IL-27, IL-17, and IFN-γ in the serum and in the aqueous humor were measured by an enzyme-linked immunosorbent assay. A laser flare-cell photometer was used to quantify intraocular inflammation.

Results: Serum IL-23, IL-27, and IFN-γ levels were significantly increased after cataract surgery in the BD versus the control patients. In the BD patients, serum levels of IFN-γ and IL-27 correlated strongly with aqueous flare values and cell counts. Remarkably, the levels of serum IL-27 were significantly associated with serum IFN-γ levels in BD patients (r=0.796; p=0.002).

Conclusions: Our data indicates that serum IFN-γ and IL-27 levels are significantly elevated in BD versus control patients and are strongly associated with post-operative intraocular inflammation.

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The comparison of cytokine levels (pg/ml) between BD patients and controls.
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f4: The comparison of cytokine levels (pg/ml) between BD patients and controls.

Mentions: Serum IL-23 levels were considerably higher in BD patients compared to control subjects preoperatively and on days 1, 7, 30, and 90 days postoperatively (p=0.003, p<0.001, p<0.001, p<0.001, and p=0.007, respectively; Figure 4).


Serum levels of Th17-related cytokines in Behcet disease patients after cataract surgery.

Jiang S, Liu X, Luo L, Qu B, Huang X, Lin Y, Ye S, Liu Y - Mol. Vis. (2011)

The comparison of cytokine levels (pg/ml) between BD patients and controls.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108896&req=5

f4: The comparison of cytokine levels (pg/ml) between BD patients and controls.
Mentions: Serum IL-23 levels were considerably higher in BD patients compared to control subjects preoperatively and on days 1, 7, 30, and 90 days postoperatively (p=0.003, p<0.001, p<0.001, p<0.001, and p=0.007, respectively; Figure 4).

Bottom Line: In the BD patients, serum levels of IFN-γ and IL-27 correlated strongly with aqueous flare values and cell counts.Remarkably, the levels of serum IL-27 were significantly associated with serum IFN-γ levels in BD patients (r=0.796; p=0.002).Our data indicates that serum IFN-γ and IL-27 levels are significantly elevated in BD versus control patients and are strongly associated with post-operative intraocular inflammation.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

ABSTRACT

Purpose: To investigate the profile of T-helper type 17 (Th17) cell-related cytokines (interleukin-23 [IL-23], IL-27, IL-17 and interferon-γ [IFN-γ]) in postoperative inflammation in patients with Behcet disease (BD) after cataract surgery.

Methods: Serum was collected from seven BD patients with complicated cataract, and from nine controls with uncomplicated cataract, before cataract surgery, and again 1, 7, 30, and 90 days after surgery. In addition, aqueous humor was collected at commencement of surgery. The protein levels of IL-23, IL-27, IL-17, and IFN-γ in the serum and in the aqueous humor were measured by an enzyme-linked immunosorbent assay. A laser flare-cell photometer was used to quantify intraocular inflammation.

Results: Serum IL-23, IL-27, and IFN-γ levels were significantly increased after cataract surgery in the BD versus the control patients. In the BD patients, serum levels of IFN-γ and IL-27 correlated strongly with aqueous flare values and cell counts. Remarkably, the levels of serum IL-27 were significantly associated with serum IFN-γ levels in BD patients (r=0.796; p=0.002).

Conclusions: Our data indicates that serum IFN-γ and IL-27 levels are significantly elevated in BD versus control patients and are strongly associated with post-operative intraocular inflammation.

Show MeSH
Related in: MedlinePlus