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Hypertension, poor glycemic control, and microalbuminuria in Cuban Americans with type 2 diabetes.

Zarini GG, Exebio JC, Gundupalli D, Nath S, Huffman FG - Int J Nephrol Renovasc Dis (2011)

Bottom Line: MAU was present in 26% of Cuban Americans with T2D.A significantly higher percentage of subjects with MA had HTN (P = 0.038) and elevated A1C (P = 0.002) than those with normoalbuminuria.The clinical significance of these findings emphasizes the early detection of MAU in this Hispanic subgroup combined with BP and good GC, which are fundamentals in preventing and treating diabetes complications and improving individuals' renal and cardiovascular outcomes.

View Article: PubMed Central - PubMed

Affiliation: Florida International University, Robert R Stempel School of Public Health, Department of Dietetics and Nutrition, Miami, Florida, USA;

ABSTRACT

Purpose: To investigate to what degree the presence of hypertension (HTN) and poor glycemic control (GC) influences the likelihood of having microalbuminuria (MAU) among Cuban Americans with type 2 diabetes (T2D).

Methods: A cross-sectional study conducted in Cuban Americans (n = 179) with T2D. Participants were recruited from a randomly generated mailing list purchased from Knowledge-Base Marketing, Inc. Blood pressure (BP) was measured twice and averaged using an adult size cuff. Glycosylated hemoglobin (A1c) levels were measured from whole blood samples with the Roche Tina-quant method. First morning urine samples were collected from each participant to determine MAU by a semiquantitative assay (ImmunoDip).

Results: MAU was present in 26% of Cuban Americans with T2D. A significantly higher percentage of subjects with MA had HTN (P = 0.038) and elevated A1C (P = 0.002) than those with normoalbuminuria. Logistic regression analysis showed that after controlling for covariates, subjects with poor GC were 6.76 times more likely to have MAU if they had hypertension compared with those without hypertension (P = 0.004; 95% confidence interval [CI]: 1.83, 23.05).

Conclusion: The clinical significance of these findings emphasizes the early detection of MAU in this Hispanic subgroup combined with BP and good GC, which are fundamentals in preventing and treating diabetes complications and improving individuals' renal and cardiovascular outcomes.

No MeSH data available.


Related in: MedlinePlus

Unadjusted odds ratios (OR) for microalbuminuria (MAU) among hypertensive Cuban Americans with poor glycemic control.aNote: aP is considered significant at 0.05.
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f1-ijnrd-4-035: Unadjusted odds ratios (OR) for microalbuminuria (MAU) among hypertensive Cuban Americans with poor glycemic control.aNote: aP is considered significant at 0.05.

Mentions: Unadjusted odds ratios indicated that subjects with poor GC were 3.96 times more likely to have positive MAU if they had HTN compared with those without HTN (P = 0.014; 95% confidence interval [CI] 1.25, 12.5) (Figure 1). Logistic regression analysis showed that after controlling for covariates, subjects with poor GC were 6.76 times more likely to have MAU if they had HTN compared with those without HTN (P = 0.004; 95% CI 1.83, 23.05) (Table 2).


Hypertension, poor glycemic control, and microalbuminuria in Cuban Americans with type 2 diabetes.

Zarini GG, Exebio JC, Gundupalli D, Nath S, Huffman FG - Int J Nephrol Renovasc Dis (2011)

Unadjusted odds ratios (OR) for microalbuminuria (MAU) among hypertensive Cuban Americans with poor glycemic control.aNote: aP is considered significant at 0.05.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3108791&req=5

f1-ijnrd-4-035: Unadjusted odds ratios (OR) for microalbuminuria (MAU) among hypertensive Cuban Americans with poor glycemic control.aNote: aP is considered significant at 0.05.
Mentions: Unadjusted odds ratios indicated that subjects with poor GC were 3.96 times more likely to have positive MAU if they had HTN compared with those without HTN (P = 0.014; 95% confidence interval [CI] 1.25, 12.5) (Figure 1). Logistic regression analysis showed that after controlling for covariates, subjects with poor GC were 6.76 times more likely to have MAU if they had HTN compared with those without HTN (P = 0.004; 95% CI 1.83, 23.05) (Table 2).

Bottom Line: MAU was present in 26% of Cuban Americans with T2D.A significantly higher percentage of subjects with MA had HTN (P = 0.038) and elevated A1C (P = 0.002) than those with normoalbuminuria.The clinical significance of these findings emphasizes the early detection of MAU in this Hispanic subgroup combined with BP and good GC, which are fundamentals in preventing and treating diabetes complications and improving individuals' renal and cardiovascular outcomes.

View Article: PubMed Central - PubMed

Affiliation: Florida International University, Robert R Stempel School of Public Health, Department of Dietetics and Nutrition, Miami, Florida, USA;

ABSTRACT

Purpose: To investigate to what degree the presence of hypertension (HTN) and poor glycemic control (GC) influences the likelihood of having microalbuminuria (MAU) among Cuban Americans with type 2 diabetes (T2D).

Methods: A cross-sectional study conducted in Cuban Americans (n = 179) with T2D. Participants were recruited from a randomly generated mailing list purchased from Knowledge-Base Marketing, Inc. Blood pressure (BP) was measured twice and averaged using an adult size cuff. Glycosylated hemoglobin (A1c) levels were measured from whole blood samples with the Roche Tina-quant method. First morning urine samples were collected from each participant to determine MAU by a semiquantitative assay (ImmunoDip).

Results: MAU was present in 26% of Cuban Americans with T2D. A significantly higher percentage of subjects with MA had HTN (P = 0.038) and elevated A1C (P = 0.002) than those with normoalbuminuria. Logistic regression analysis showed that after controlling for covariates, subjects with poor GC were 6.76 times more likely to have MAU if they had hypertension compared with those without hypertension (P = 0.004; 95% confidence interval [CI]: 1.83, 23.05).

Conclusion: The clinical significance of these findings emphasizes the early detection of MAU in this Hispanic subgroup combined with BP and good GC, which are fundamentals in preventing and treating diabetes complications and improving individuals' renal and cardiovascular outcomes.

No MeSH data available.


Related in: MedlinePlus