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Effect of angiotensin II blockade on central blood pressure and arterial stiffness in subjects with hypertension.

Safar ME - Int J Nephrol Renovasc Dis (2010)

Bottom Line: The angiotensin-converting enzyme (ACE) inhibitor perindopril not only reduces mean arterial pressure but also acts specifically on pulse pressure.In hypertensive subjects, perindopril and other ACE inhibitors seem to predict more consistently the reduction of cardiovascular events, mainly of cardiac origin, than standard β-blockers alone.This effect is associated with the important biochemical finding that mechanotransductions of angiotensin and β-blockade are markedly different, acting in the former specifically on the α5β1 integrin complex and on the fibronectin ligand of arterial vessels.

View Article: PubMed Central - PubMed

Affiliation: Université Paris Descartes, Assistance Publique-Hôpitaux de Paris, Hôtel-Dieu Centre de Diagnostic et de Thérapeutique, Paris, France. michel.safar@htd.aphp.fr

No MeSH data available.


Related in: MedlinePlus

The different components of the pulsatile blood pressure curve.1–3 For mean arterial pressure, the area under the mean arterial pressure curve is exactly equal to the area under the pulsatile blood pressure curve, which means that the two curves are able to produce exactly the same cardiac work.1–3
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f1-ijnrd-3-167: The different components of the pulsatile blood pressure curve.1–3 For mean arterial pressure, the area under the mean arterial pressure curve is exactly equal to the area under the pulsatile blood pressure curve, which means that the two curves are able to produce exactly the same cardiac work.1–3

Mentions: Blood pressure is the force applied per unit area on a given vessel, which determines the flow of blood. Pressure and flow result from the properties of the heart as a pump and the characteristics of the arterial system. However, pressure and flow vary during the cardiac cycle and are therefore called pulsatile pressure and flow. When the BP curve is submitted to Fourier analysis and written as a series of sine waves, these waves are called oscillatory pressure and flow. The zero term equals the mean value (mean arterial pressure) of BP, and the harmonics are the oscillatory terms, summarized by pulse pressure (pulse pressure = systolic BP – diastolic BP, see Figure 1).


Effect of angiotensin II blockade on central blood pressure and arterial stiffness in subjects with hypertension.

Safar ME - Int J Nephrol Renovasc Dis (2010)

The different components of the pulsatile blood pressure curve.1–3 For mean arterial pressure, the area under the mean arterial pressure curve is exactly equal to the area under the pulsatile blood pressure curve, which means that the two curves are able to produce exactly the same cardiac work.1–3
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3108785&req=5

f1-ijnrd-3-167: The different components of the pulsatile blood pressure curve.1–3 For mean arterial pressure, the area under the mean arterial pressure curve is exactly equal to the area under the pulsatile blood pressure curve, which means that the two curves are able to produce exactly the same cardiac work.1–3
Mentions: Blood pressure is the force applied per unit area on a given vessel, which determines the flow of blood. Pressure and flow result from the properties of the heart as a pump and the characteristics of the arterial system. However, pressure and flow vary during the cardiac cycle and are therefore called pulsatile pressure and flow. When the BP curve is submitted to Fourier analysis and written as a series of sine waves, these waves are called oscillatory pressure and flow. The zero term equals the mean value (mean arterial pressure) of BP, and the harmonics are the oscillatory terms, summarized by pulse pressure (pulse pressure = systolic BP – diastolic BP, see Figure 1).

Bottom Line: The angiotensin-converting enzyme (ACE) inhibitor perindopril not only reduces mean arterial pressure but also acts specifically on pulse pressure.In hypertensive subjects, perindopril and other ACE inhibitors seem to predict more consistently the reduction of cardiovascular events, mainly of cardiac origin, than standard β-blockers alone.This effect is associated with the important biochemical finding that mechanotransductions of angiotensin and β-blockade are markedly different, acting in the former specifically on the α5β1 integrin complex and on the fibronectin ligand of arterial vessels.

View Article: PubMed Central - PubMed

Affiliation: Université Paris Descartes, Assistance Publique-Hôpitaux de Paris, Hôtel-Dieu Centre de Diagnostic et de Thérapeutique, Paris, France. michel.safar@htd.aphp.fr

No MeSH data available.


Related in: MedlinePlus