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Clinical utility of tolvaptan in the management of hyponatremia in heart failure patients.

Nodari S, Jao GT, Chiong JR - Int J Nephrol Renovasc Dis (2010)

Bottom Line: It is caused by deregulation of arginine vasopressin (AVP) homeostasis associated with water retention in hypervolemic or in euvolemic states.While hypervolemic hypotonic hyponatremia is also seen in advanced liver cirrhosis, renal failure, and nephrotic syndrome, the bulk of evidence associating this electrolyte disorder to increasing morbidity and mortality can be found in the HF literature.Conventional therapeutic approaches, ie, restriction of fluid intake, saline and diuretics, can be effective, but often the results are unpredictable.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, University of Brescia, Brescia, Italy.

No MeSH data available.


Related in: MedlinePlus

Hyponatremia and prognosis in heart failure patients.Abbreviation: LOS, length of stay.
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f1-ijnrd-3-051: Hyponatremia and prognosis in heart failure patients.Abbreviation: LOS, length of stay.

Mentions: An analysis from the OPTIMIZE-HF registry of 48,612 patients with AHFS showed a relationship between admission serum sodium concentration and clinical outcomes.16 Hyponatremia was present in 20% of the OPTIMIZE-HF cohorts with similar prevalence in patients with reduced or preserved ejection fraction. Lower admission serum sodium levels were associated with higher in-hospital mortality and longer mean hospital length of stay. In the follow up cohort, admission hyponatremia was associated with higher 60- to 90-day mortality. Admission serum sodium concentration remained a significant independent predictor of outcomes after adjustment for other prognostic factors (Figure 1).


Clinical utility of tolvaptan in the management of hyponatremia in heart failure patients.

Nodari S, Jao GT, Chiong JR - Int J Nephrol Renovasc Dis (2010)

Hyponatremia and prognosis in heart failure patients.Abbreviation: LOS, length of stay.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3108784&req=5

f1-ijnrd-3-051: Hyponatremia and prognosis in heart failure patients.Abbreviation: LOS, length of stay.
Mentions: An analysis from the OPTIMIZE-HF registry of 48,612 patients with AHFS showed a relationship between admission serum sodium concentration and clinical outcomes.16 Hyponatremia was present in 20% of the OPTIMIZE-HF cohorts with similar prevalence in patients with reduced or preserved ejection fraction. Lower admission serum sodium levels were associated with higher in-hospital mortality and longer mean hospital length of stay. In the follow up cohort, admission hyponatremia was associated with higher 60- to 90-day mortality. Admission serum sodium concentration remained a significant independent predictor of outcomes after adjustment for other prognostic factors (Figure 1).

Bottom Line: It is caused by deregulation of arginine vasopressin (AVP) homeostasis associated with water retention in hypervolemic or in euvolemic states.While hypervolemic hypotonic hyponatremia is also seen in advanced liver cirrhosis, renal failure, and nephrotic syndrome, the bulk of evidence associating this electrolyte disorder to increasing morbidity and mortality can be found in the HF literature.Conventional therapeutic approaches, ie, restriction of fluid intake, saline and diuretics, can be effective, but often the results are unpredictable.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, University of Brescia, Brescia, Italy.

No MeSH data available.


Related in: MedlinePlus