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Renovascular and renoprotective properties of telmisartan: clinical utility.

Ladino M, Hernandez Schulman I - Int J Nephrol Renovasc Dis (2010)

Bottom Line: Chronic kidney disease (CKD) affects approximately 26 million adults in the United States and millions of others are at increased risk.Telmisartan is a long-acting ARB with pharmacological properties beyond blockade of the angiotensin II type 1 receptor, including activation of the peroxisome proliferator activated receptor-γ (PPAR-γ).This article reviews the beneficial renal and vascular protective effects of telmisartan.

View Article: PubMed Central - PubMed

Affiliation: Nephrology-Hypertension Section, Veterans Affairs Medical Center and Division of Nephrology and Hypertension and Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL, USA. ischulman@med.miami.edu

No MeSH data available.


Related in: MedlinePlus

Effects of angiotensin II on the AT1 receptor.
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f1-ijnrd-3-033: Effects of angiotensin II on the AT1 receptor.

Mentions: Angiotensin II is the most studied effector peptide of the renin-angiotensin system. It is produced from angiotensin I by ACE and has effects in multiple organs of the human body. There are 4 types of angiotensin receptors (AT1, AT2, AT3, AT4). AT1 is the receptor that enables most of the hemodynamic changes in the body that are related to angiotensin II, these include vasoconstriction and stimulation of aldosterone release (Figure 1). In response to angiotensin II, there is an increase in glomerular pressure and glomerular permselectivity as well as activation of fibrosis and cellular growth in the kidney.


Renovascular and renoprotective properties of telmisartan: clinical utility.

Ladino M, Hernandez Schulman I - Int J Nephrol Renovasc Dis (2010)

Effects of angiotensin II on the AT1 receptor.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3108769&req=5

f1-ijnrd-3-033: Effects of angiotensin II on the AT1 receptor.
Mentions: Angiotensin II is the most studied effector peptide of the renin-angiotensin system. It is produced from angiotensin I by ACE and has effects in multiple organs of the human body. There are 4 types of angiotensin receptors (AT1, AT2, AT3, AT4). AT1 is the receptor that enables most of the hemodynamic changes in the body that are related to angiotensin II, these include vasoconstriction and stimulation of aldosterone release (Figure 1). In response to angiotensin II, there is an increase in glomerular pressure and glomerular permselectivity as well as activation of fibrosis and cellular growth in the kidney.

Bottom Line: Chronic kidney disease (CKD) affects approximately 26 million adults in the United States and millions of others are at increased risk.Telmisartan is a long-acting ARB with pharmacological properties beyond blockade of the angiotensin II type 1 receptor, including activation of the peroxisome proliferator activated receptor-γ (PPAR-γ).This article reviews the beneficial renal and vascular protective effects of telmisartan.

View Article: PubMed Central - PubMed

Affiliation: Nephrology-Hypertension Section, Veterans Affairs Medical Center and Division of Nephrology and Hypertension and Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL, USA. ischulman@med.miami.edu

No MeSH data available.


Related in: MedlinePlus