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Nephrotic presentation in hydatid cyst disease with predominant tubulointerstital disease.

Aziz F, Pandya T, Patel HV, Ramakrishna P, Goplani KR, Gumber M, Vanikar AV, Kanodia K, Shah PR, Trivedi HL - Int J Nephrol Renovasc Dis (2009)

Bottom Line: Renal involvement, which can rarely occur in echinococcosis, more commonly manifests as hydatid cyst of the kidney.Scattered case reports of nephrotic syndrome secondary to hydatid cyst in the liver or lung have been reported for over two decades.The glomerular picture varied from minimal change lesion to mesangiocapillary glomerulonephritis.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephrology and Transplantation Medicine;

ABSTRACT
Renal involvement, which can rarely occur in echinococcosis, more commonly manifests as hydatid cyst of the kidney. Scattered case reports of nephrotic syndrome secondary to hydatid cyst in the liver or lung have been reported for over two decades. The glomerular picture varied from minimal change lesion to mesangiocapillary glomerulonephritis. We report a case of predominantly tubulointerstitial nephritis with mesangioproliferative glomerulonephritis in a patient with hepatic hydatid cyst which responded to cyst resection alone.

No MeSH data available.


Related in: MedlinePlus

Glomeruli showed moderate mesangial matrix accentuation with hypercellularity. Capillary lumina were open with thickened, wrinkled membranes. Bowman’s capillary segmentally thickened and occasionally ruptured. Tubules had moderate degenerative changes. Mild interstitial edema with diffuse mixed leucocytic infiltration noted.Note: Immunoflouresence showed nonspecific IgM trapping.
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f2-ijnrd-2-023: Glomeruli showed moderate mesangial matrix accentuation with hypercellularity. Capillary lumina were open with thickened, wrinkled membranes. Bowman’s capillary segmentally thickened and occasionally ruptured. Tubules had moderate degenerative changes. Mild interstitial edema with diffuse mixed leucocytic infiltration noted.Note: Immunoflouresence showed nonspecific IgM trapping.

Mentions: Chest X-ray revealed a raised right hemidiaphragm. Renal ultrasound showed normal kidneys except for slightly increased echogenecity. Liver ultrasound showed fluid filled cavity of 9.3 × 8.1 cm with multiple cysts within it in the left lobe of liver. Ultrasound also revealed mild ascites. Serology for Echinococcus granulosus (IgG/IgM) was positive. Computed tomography (CT) scan of the abdomen showed an 11 × 10 × 6 cm cystic lesion with areas of rim calcification and few small cysts within it in the left lobe of liver which was extending into the lesser sac (Figure 1). Mild ascites were also noted. The above findings confirmed the diagnosis of hydatid disease of liver. The patient was subjected to renal biopsy as it was a nephrotic presentation. Renal biopsy revealed mesangial proliferation with acute on chronic tubulo-interstitial nephritis (Figures 2, 3). Electron microscopy was not done as there was no in-house facility.


Nephrotic presentation in hydatid cyst disease with predominant tubulointerstital disease.

Aziz F, Pandya T, Patel HV, Ramakrishna P, Goplani KR, Gumber M, Vanikar AV, Kanodia K, Shah PR, Trivedi HL - Int J Nephrol Renovasc Dis (2009)

Glomeruli showed moderate mesangial matrix accentuation with hypercellularity. Capillary lumina were open with thickened, wrinkled membranes. Bowman’s capillary segmentally thickened and occasionally ruptured. Tubules had moderate degenerative changes. Mild interstitial edema with diffuse mixed leucocytic infiltration noted.Note: Immunoflouresence showed nonspecific IgM trapping.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3108760&req=5

f2-ijnrd-2-023: Glomeruli showed moderate mesangial matrix accentuation with hypercellularity. Capillary lumina were open with thickened, wrinkled membranes. Bowman’s capillary segmentally thickened and occasionally ruptured. Tubules had moderate degenerative changes. Mild interstitial edema with diffuse mixed leucocytic infiltration noted.Note: Immunoflouresence showed nonspecific IgM trapping.
Mentions: Chest X-ray revealed a raised right hemidiaphragm. Renal ultrasound showed normal kidneys except for slightly increased echogenecity. Liver ultrasound showed fluid filled cavity of 9.3 × 8.1 cm with multiple cysts within it in the left lobe of liver. Ultrasound also revealed mild ascites. Serology for Echinococcus granulosus (IgG/IgM) was positive. Computed tomography (CT) scan of the abdomen showed an 11 × 10 × 6 cm cystic lesion with areas of rim calcification and few small cysts within it in the left lobe of liver which was extending into the lesser sac (Figure 1). Mild ascites were also noted. The above findings confirmed the diagnosis of hydatid disease of liver. The patient was subjected to renal biopsy as it was a nephrotic presentation. Renal biopsy revealed mesangial proliferation with acute on chronic tubulo-interstitial nephritis (Figures 2, 3). Electron microscopy was not done as there was no in-house facility.

Bottom Line: Renal involvement, which can rarely occur in echinococcosis, more commonly manifests as hydatid cyst of the kidney.Scattered case reports of nephrotic syndrome secondary to hydatid cyst in the liver or lung have been reported for over two decades.The glomerular picture varied from minimal change lesion to mesangiocapillary glomerulonephritis.

View Article: PubMed Central - PubMed

Affiliation: Department of Nephrology and Transplantation Medicine;

ABSTRACT
Renal involvement, which can rarely occur in echinococcosis, more commonly manifests as hydatid cyst of the kidney. Scattered case reports of nephrotic syndrome secondary to hydatid cyst in the liver or lung have been reported for over two decades. The glomerular picture varied from minimal change lesion to mesangiocapillary glomerulonephritis. We report a case of predominantly tubulointerstitial nephritis with mesangioproliferative glomerulonephritis in a patient with hepatic hydatid cyst which responded to cyst resection alone.

No MeSH data available.


Related in: MedlinePlus