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Multidrug and extensively drug-resistant tuberculosis from a general practice perspective.

Yashodhara BM, Huat CB, Naik LN, Umakanth S, Hande M, Pappachan JM - Infect Drug Resist (2010)

Bottom Line: For patients with multidrug-resistant tuberculosis, the WHO recommends a DOTS-Plus treatment strategy.Early detection and prompt treatment of multidrug-resistant tuberculosis is crucial to avoid spread of the disease and also because of the chances of development of potentially incurable extensively drug-resistant tuberculosis in these cases.This review discusses the epidemiologic, diagnostic, and therapeutic aspects of multidrug-resistant tuberculosis, and also outlines the role of primary care doctors in the management of this dangerous disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Melaka Manipal Medical College, Melaka, India;

ABSTRACT
Despite intensive efforts to eradicate the disease, tuberculosis continues to be a major threat to Indian society, with an estimated prevalence of 3.45 million cases in 2006. Emergence of multidrug-resistant tuberculosis has complicated eradication attempts in recent years. Incomplete and/inadequate treatment are the main causes for development of drug resistance. Directly observed therapy, short-course (DOTS) is the World Health Organization (WHO) strategy for worldwide eradication of tuberculosis, and our country achieved 100% coverage for DOTS through the Revised National Tuberculosis Control Program in 2006. For patients with multidrug-resistant tuberculosis, the WHO recommends a DOTS-Plus treatment strategy. Early detection and prompt treatment of multidrug-resistant tuberculosis is crucial to avoid spread of the disease and also because of the chances of development of potentially incurable extensively drug-resistant tuberculosis in these cases. This review discusses the epidemiologic, diagnostic, and therapeutic aspects of multidrug-resistant tuberculosis, and also outlines the role of primary care doctors in the management of this dangerous disease.

No MeSH data available.


Related in: MedlinePlus

Approach to cases with interrupted category II treatment to avoid multidrug-resistant tuberculosis.1
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f1-idr-3-115: Approach to cases with interrupted category II treatment to avoid multidrug-resistant tuberculosis.1

Mentions: General practitioners and primary care physicians have key roles in the successful management of tuberculosis and thus preventing emergence of multidrug resistance in patients. Implementation of DOTS in India should be mainly done in the primary care setting because most of the population reside in rural areas. Timely identification and prompt referral of suspected cases to specialty care facilities for DOTS-Plus are the main roles of primary care doctors in the management of multidrug-resistant tuberculosis. Default from drug treatment is one of the major causes of multidrug resistance, and hence vigilance should be exercised in handling such cases. Figure 1 shows the approach to cases with interrupted category II treatment to prevent emergence of multidrug-resistant tuberculosis.


Multidrug and extensively drug-resistant tuberculosis from a general practice perspective.

Yashodhara BM, Huat CB, Naik LN, Umakanth S, Hande M, Pappachan JM - Infect Drug Resist (2010)

Approach to cases with interrupted category II treatment to avoid multidrug-resistant tuberculosis.1
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3108735&req=5

f1-idr-3-115: Approach to cases with interrupted category II treatment to avoid multidrug-resistant tuberculosis.1
Mentions: General practitioners and primary care physicians have key roles in the successful management of tuberculosis and thus preventing emergence of multidrug resistance in patients. Implementation of DOTS in India should be mainly done in the primary care setting because most of the population reside in rural areas. Timely identification and prompt referral of suspected cases to specialty care facilities for DOTS-Plus are the main roles of primary care doctors in the management of multidrug-resistant tuberculosis. Default from drug treatment is one of the major causes of multidrug resistance, and hence vigilance should be exercised in handling such cases. Figure 1 shows the approach to cases with interrupted category II treatment to prevent emergence of multidrug-resistant tuberculosis.

Bottom Line: For patients with multidrug-resistant tuberculosis, the WHO recommends a DOTS-Plus treatment strategy.Early detection and prompt treatment of multidrug-resistant tuberculosis is crucial to avoid spread of the disease and also because of the chances of development of potentially incurable extensively drug-resistant tuberculosis in these cases.This review discusses the epidemiologic, diagnostic, and therapeutic aspects of multidrug-resistant tuberculosis, and also outlines the role of primary care doctors in the management of this dangerous disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, Melaka Manipal Medical College, Melaka, India;

ABSTRACT
Despite intensive efforts to eradicate the disease, tuberculosis continues to be a major threat to Indian society, with an estimated prevalence of 3.45 million cases in 2006. Emergence of multidrug-resistant tuberculosis has complicated eradication attempts in recent years. Incomplete and/inadequate treatment are the main causes for development of drug resistance. Directly observed therapy, short-course (DOTS) is the World Health Organization (WHO) strategy for worldwide eradication of tuberculosis, and our country achieved 100% coverage for DOTS through the Revised National Tuberculosis Control Program in 2006. For patients with multidrug-resistant tuberculosis, the WHO recommends a DOTS-Plus treatment strategy. Early detection and prompt treatment of multidrug-resistant tuberculosis is crucial to avoid spread of the disease and also because of the chances of development of potentially incurable extensively drug-resistant tuberculosis in these cases. This review discusses the epidemiologic, diagnostic, and therapeutic aspects of multidrug-resistant tuberculosis, and also outlines the role of primary care doctors in the management of this dangerous disease.

No MeSH data available.


Related in: MedlinePlus