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Infliximab therapy for moderately severe Crohn's disease and ulcerative colitis: a retrospective comparison over 6 years.

Alzafiri R, Holcroft CA, Malolepszy P, Cohen A, Szilagyi A - Clin Exp Gastroenterol (2011)

Bottom Line: Evaluation of long-term outcome of therapy for both diseases.Few serious side effects were noted.No important statistically significant differences in treatment patterns or outcome were observed between the groups.

View Article: PubMed Central - PubMed

Affiliation: Jewish General Hospital, Division of Gastroenterology, Department of Medicine, McGill University School of Medicine, Montreal, Quebec, Canada;

ABSTRACT

Background: Infliximab has shown benefit in Crohn's disease (CD) and ulcerative colitis (UC).

Objective: Evaluation of long-term outcome of therapy for both diseases.

Methods: We analyzed retrospectively patients treated at infusion centers from one institution. Demographic, laboratory parameters leading up to biologic therapy and the subsequent pattern of outcomes in either disease were established as a database. Initial failure, subsequent need to change therapy, or need to adjust therapy were evaluated. Kruskal-Wallis (nonparametric) tests to compare two groups and Kaplan-Meier survival curve analysis were used to compare outcomes.

Results: Over approximately 6 years, 71 CD and 26 UC patients received 999 and 215 infusions, respectively, for a median of 62 months. Of these, 17% for CD and 19% for UC patients were primary failures. Following the start of infliximab, 18% of CD and 11% of UC patients required stoppage and switching to another type of therapy. In either CD or UC patients, 54% or 62%, respectively, continued therapy without the need to change to other treatments. Few serious side effects were noted. No important statistically significant differences in treatment patterns or outcome were observed between the groups.

Discussion: Long-term treatment of both inflammatory bowel diseases reflects outcomes of clinical trials.

Conclusions: This study emphasizes similarities between CD and UC and reports therapeutic success for an extended time.

No MeSH data available.


Related in: MedlinePlus

The distribution of the number of infusions (by year) and year of start of IFX treatment by disease group are shown (N = 97). Some patients who were tracked at infusion centers during the period of interest of the study began therapy earlier (also described in Methods).Abbreviations: CD, Crohn’s disease; IFX, infliximab; UC, ulcerative colitis.
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f1-ceg-4-009: The distribution of the number of infusions (by year) and year of start of IFX treatment by disease group are shown (N = 97). Some patients who were tracked at infusion centers during the period of interest of the study began therapy earlier (also described in Methods).Abbreviations: CD, Crohn’s disease; IFX, infliximab; UC, ulcerative colitis.

Mentions: The yearly distribution of IFX initiation between 2000 and 2008 is shown in Figure 1. There were 1214 infusions (999 for CD and 215 for UC). The median infusions per patient was 12 (range 2–48) for CD and seven (range 2–32) for UC. For the entire group, the median time of follow-up based on length of treatment was 62 months. This is derived from the survival curve in Figure 2.


Infliximab therapy for moderately severe Crohn's disease and ulcerative colitis: a retrospective comparison over 6 years.

Alzafiri R, Holcroft CA, Malolepszy P, Cohen A, Szilagyi A - Clin Exp Gastroenterol (2011)

The distribution of the number of infusions (by year) and year of start of IFX treatment by disease group are shown (N = 97). Some patients who were tracked at infusion centers during the period of interest of the study began therapy earlier (also described in Methods).Abbreviations: CD, Crohn’s disease; IFX, infliximab; UC, ulcerative colitis.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3108681&req=5

f1-ceg-4-009: The distribution of the number of infusions (by year) and year of start of IFX treatment by disease group are shown (N = 97). Some patients who were tracked at infusion centers during the period of interest of the study began therapy earlier (also described in Methods).Abbreviations: CD, Crohn’s disease; IFX, infliximab; UC, ulcerative colitis.
Mentions: The yearly distribution of IFX initiation between 2000 and 2008 is shown in Figure 1. There were 1214 infusions (999 for CD and 215 for UC). The median infusions per patient was 12 (range 2–48) for CD and seven (range 2–32) for UC. For the entire group, the median time of follow-up based on length of treatment was 62 months. This is derived from the survival curve in Figure 2.

Bottom Line: Evaluation of long-term outcome of therapy for both diseases.Few serious side effects were noted.No important statistically significant differences in treatment patterns or outcome were observed between the groups.

View Article: PubMed Central - PubMed

Affiliation: Jewish General Hospital, Division of Gastroenterology, Department of Medicine, McGill University School of Medicine, Montreal, Quebec, Canada;

ABSTRACT

Background: Infliximab has shown benefit in Crohn's disease (CD) and ulcerative colitis (UC).

Objective: Evaluation of long-term outcome of therapy for both diseases.

Methods: We analyzed retrospectively patients treated at infusion centers from one institution. Demographic, laboratory parameters leading up to biologic therapy and the subsequent pattern of outcomes in either disease were established as a database. Initial failure, subsequent need to change therapy, or need to adjust therapy were evaluated. Kruskal-Wallis (nonparametric) tests to compare two groups and Kaplan-Meier survival curve analysis were used to compare outcomes.

Results: Over approximately 6 years, 71 CD and 26 UC patients received 999 and 215 infusions, respectively, for a median of 62 months. Of these, 17% for CD and 19% for UC patients were primary failures. Following the start of infliximab, 18% of CD and 11% of UC patients required stoppage and switching to another type of therapy. In either CD or UC patients, 54% or 62%, respectively, continued therapy without the need to change to other treatments. Few serious side effects were noted. No important statistically significant differences in treatment patterns or outcome were observed between the groups.

Discussion: Long-term treatment of both inflammatory bowel diseases reflects outcomes of clinical trials.

Conclusions: This study emphasizes similarities between CD and UC and reports therapeutic success for an extended time.

No MeSH data available.


Related in: MedlinePlus