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High-dose rifaximin treatment alleviates global symptoms of irritable bowel syndrome.

Jolley J - Clin Exp Gastroenterol (2011)

Bottom Line: Forty-nine percent of patients who received initial rifaximin and 47% of patients who received high-dose rifaximin achieved ≥50% global symptom improvement during at least one follow-up visit.Rifaximin was well tolerated.Patients with incomplete symptom resolution may respond to increased doses of rifaximin.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, University of California, San Francisco, CA, USA.

ABSTRACT

Background: To evaluate the efficacy of rifaximin for reduction of gastrointestinal symptoms in patients with irritable bowel syndrome (IBS).

Methods: Medical records were identified for consecutive patients diagnosed with IBS according to Rome III criteria, who had abnormal lactulose breath test results and had received rifaximin 1200 mg/day for 10 days. The efficacy of rifaximin for reducing gastrointestinal symptoms and for eradicating small intestinal bacterial overgrowth was ascertained in these patients. In addition, these endpoints were examined in patients who were initially unresponsive to rifaximin 1200 mg/day and received subsequent rifaximin 2400 mg/day.

Results: Patients who received rifaximin 1200 mg/day (n = 162) experienced a mean improvement of 52% in global IBS symptoms at the end of rifaximin treatment. Similarly, initially unresponsive patients who received additional rifaximin 2400 mg/day (n = 81) experienced a 53% mean improvement in global IBS symptoms. Forty-nine percent of patients who received initial rifaximin and 47% of patients who received high-dose rifaximin achieved ≥50% global symptom improvement during at least one follow-up visit. Normalization of lactulose breath test results was only apparent in some patients who received high-dose rifaximin. Rifaximin was well tolerated.

Conclusion: Rifaximin 1200 mg/day for 10 days reduced gastrointestinal symptoms in patients with IBS. Patients with incomplete symptom resolution may respond to increased doses of rifaximin.

No MeSH data available.


Related in: MedlinePlus

Percentage of patients obtaining ≥50% best global improvement following rifaximin treatment. Global symptoms improved in 79 of 162 patients (49%) who received rifaximin 1200 mg/day for 10 days compared with 38 of 81 patients (47%) who received high-dose rifaximin (2400 mg/day) for 10 days.Note: aIncludes patients who received additional high-dose rifaximin therapy.
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f2-ceg-4-043: Percentage of patients obtaining ≥50% best global improvement following rifaximin treatment. Global symptoms improved in 79 of 162 patients (49%) who received rifaximin 1200 mg/day for 10 days compared with 38 of 81 patients (47%) who received high-dose rifaximin (2400 mg/day) for 10 days.Note: aIncludes patients who received additional high-dose rifaximin therapy.

Mentions: Patients who received rifaximin 1200 mg/day experienced a mean improvement of 52% in global IBS symptoms at the end of rifaximin treatment (Figure 1). In addition, after initial rifaximin 1200 mg/day for 10 days, 49% of patients (79 of 162) reported ≥50% best global improvement in IBS symptoms (Figure 2). This improvement was IBS-subtype specific, with 56% of patients (25 of 45) diagnosed with diarrhea-predominant IBS experiencing ≥50% best global improvement compared with 45% of individuals (15 of 33) with constipation-predominant IBS (Figure 3). Complete symptom relief (≥91% improvement) was achieved in 19 of 162 patients (12%) and was not dependent on IBS subcategory (Table 2). Eight percent of patients (13 of 162) achieved partial relief (1%–90%) of overall symptoms, with individuals having constipation-predominant IBS receiving the greatest benefit. The predominant symptom (diarrhea or constipation) was completely relieved in 13% of patients with diarrhea-predominant IBS and in 12% of patients with constipation-predominant IBS (Table 2). Similarly, 17% of patients with mixed-symptom IBS displayed complete relief of diarrhea, and 13% had complete relief of constipation (Table 2). Only 2% of patients treated with initial rifaximin displayed a normal lactulose breath test result post-treatment.


High-dose rifaximin treatment alleviates global symptoms of irritable bowel syndrome.

Jolley J - Clin Exp Gastroenterol (2011)

Percentage of patients obtaining ≥50% best global improvement following rifaximin treatment. Global symptoms improved in 79 of 162 patients (49%) who received rifaximin 1200 mg/day for 10 days compared with 38 of 81 patients (47%) who received high-dose rifaximin (2400 mg/day) for 10 days.Note: aIncludes patients who received additional high-dose rifaximin therapy.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3108677&req=5

f2-ceg-4-043: Percentage of patients obtaining ≥50% best global improvement following rifaximin treatment. Global symptoms improved in 79 of 162 patients (49%) who received rifaximin 1200 mg/day for 10 days compared with 38 of 81 patients (47%) who received high-dose rifaximin (2400 mg/day) for 10 days.Note: aIncludes patients who received additional high-dose rifaximin therapy.
Mentions: Patients who received rifaximin 1200 mg/day experienced a mean improvement of 52% in global IBS symptoms at the end of rifaximin treatment (Figure 1). In addition, after initial rifaximin 1200 mg/day for 10 days, 49% of patients (79 of 162) reported ≥50% best global improvement in IBS symptoms (Figure 2). This improvement was IBS-subtype specific, with 56% of patients (25 of 45) diagnosed with diarrhea-predominant IBS experiencing ≥50% best global improvement compared with 45% of individuals (15 of 33) with constipation-predominant IBS (Figure 3). Complete symptom relief (≥91% improvement) was achieved in 19 of 162 patients (12%) and was not dependent on IBS subcategory (Table 2). Eight percent of patients (13 of 162) achieved partial relief (1%–90%) of overall symptoms, with individuals having constipation-predominant IBS receiving the greatest benefit. The predominant symptom (diarrhea or constipation) was completely relieved in 13% of patients with diarrhea-predominant IBS and in 12% of patients with constipation-predominant IBS (Table 2). Similarly, 17% of patients with mixed-symptom IBS displayed complete relief of diarrhea, and 13% had complete relief of constipation (Table 2). Only 2% of patients treated with initial rifaximin displayed a normal lactulose breath test result post-treatment.

Bottom Line: Forty-nine percent of patients who received initial rifaximin and 47% of patients who received high-dose rifaximin achieved ≥50% global symptom improvement during at least one follow-up visit.Rifaximin was well tolerated.Patients with incomplete symptom resolution may respond to increased doses of rifaximin.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, University of California, San Francisco, CA, USA.

ABSTRACT

Background: To evaluate the efficacy of rifaximin for reduction of gastrointestinal symptoms in patients with irritable bowel syndrome (IBS).

Methods: Medical records were identified for consecutive patients diagnosed with IBS according to Rome III criteria, who had abnormal lactulose breath test results and had received rifaximin 1200 mg/day for 10 days. The efficacy of rifaximin for reducing gastrointestinal symptoms and for eradicating small intestinal bacterial overgrowth was ascertained in these patients. In addition, these endpoints were examined in patients who were initially unresponsive to rifaximin 1200 mg/day and received subsequent rifaximin 2400 mg/day.

Results: Patients who received rifaximin 1200 mg/day (n = 162) experienced a mean improvement of 52% in global IBS symptoms at the end of rifaximin treatment. Similarly, initially unresponsive patients who received additional rifaximin 2400 mg/day (n = 81) experienced a 53% mean improvement in global IBS symptoms. Forty-nine percent of patients who received initial rifaximin and 47% of patients who received high-dose rifaximin achieved ≥50% global symptom improvement during at least one follow-up visit. Normalization of lactulose breath test results was only apparent in some patients who received high-dose rifaximin. Rifaximin was well tolerated.

Conclusion: Rifaximin 1200 mg/day for 10 days reduced gastrointestinal symptoms in patients with IBS. Patients with incomplete symptom resolution may respond to increased doses of rifaximin.

No MeSH data available.


Related in: MedlinePlus