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The role of somatostatin in 67 consecutive pancreatectomies: a randomized clinical trial.

Katsourakis A, Oikonomou L, Chatzitheoklitos E, Noussios G, Pitiakoudis M, Polychronidis A, Simopoulos K, Sioga A - Clin Exp Gastroenterol (2010)

Bottom Line: Biopsies were taken and processed for electron microscopy and ultrastructural morphometric analysis.Administration of somatostatin reduced the exocrine granule number, and the patients suffered from fewer postoperative complications.Somatostatin reduces granule number and size of pancreatic cells, which can partially explain the prophylactic effect of the drug on early complications of pancreatic surgery, and which is confirmed by the clinical findings.

View Article: PubMed Central - PubMed

Affiliation: Surgical Department of "Agios Dimitrios" General Hospital, Thessaloniki, Greece;

ABSTRACT

Background: Somatostatin has been found to be effective in the prevention of postoperative complications in pancreatic surgery. It can inhibit the pancreatic secretions that, quite often, are responsible for complications during the postoperative period.

Methods: We randomized 67 patients in 2 groups. In the study group (n = 35), somatostatin was administered 30 minutes prior to surgery as well as intraoperatively and postoperatively. No medication was given to the control group (n = 32). Biopsies were taken and processed for electron microscopy and ultrastructural morphometric analysis.

Results: Administration of somatostatin reduced the exocrine granule number, and the patients suffered from fewer postoperative complications.

Conclusions: Somatostatin reduces granule number and size of pancreatic cells, which can partially explain the prophylactic effect of the drug on early complications of pancreatic surgery, and which is confirmed by the clinical findings.

No MeSH data available.


Related in: MedlinePlus

Exocrine acini of pancreas, with administration of somatostatin.Abbreviation: N, nucleus × 5000.
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f4-ceg-3-179: Exocrine acini of pancreas, with administration of somatostatin.Abbreviation: N, nucleus × 5000.

Mentions: The fine structure of the acinar cells after the administration of somatostatin was different. Many of the acinar cells had few granules or none at all. The electron density of membrane-bound granules varied. The cell organelles (rough endoplasmic reticulum, c. Golgi) were few (Figures 3 and 4). There were also acinar cells with a physiological appearance and many granules, as in the case of the control group. A reduction in size was observed in almost all acinar cells in more than 80% of cases.


The role of somatostatin in 67 consecutive pancreatectomies: a randomized clinical trial.

Katsourakis A, Oikonomou L, Chatzitheoklitos E, Noussios G, Pitiakoudis M, Polychronidis A, Simopoulos K, Sioga A - Clin Exp Gastroenterol (2010)

Exocrine acini of pancreas, with administration of somatostatin.Abbreviation: N, nucleus × 5000.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3108665&req=5

f4-ceg-3-179: Exocrine acini of pancreas, with administration of somatostatin.Abbreviation: N, nucleus × 5000.
Mentions: The fine structure of the acinar cells after the administration of somatostatin was different. Many of the acinar cells had few granules or none at all. The electron density of membrane-bound granules varied. The cell organelles (rough endoplasmic reticulum, c. Golgi) were few (Figures 3 and 4). There were also acinar cells with a physiological appearance and many granules, as in the case of the control group. A reduction in size was observed in almost all acinar cells in more than 80% of cases.

Bottom Line: Biopsies were taken and processed for electron microscopy and ultrastructural morphometric analysis.Administration of somatostatin reduced the exocrine granule number, and the patients suffered from fewer postoperative complications.Somatostatin reduces granule number and size of pancreatic cells, which can partially explain the prophylactic effect of the drug on early complications of pancreatic surgery, and which is confirmed by the clinical findings.

View Article: PubMed Central - PubMed

Affiliation: Surgical Department of "Agios Dimitrios" General Hospital, Thessaloniki, Greece;

ABSTRACT

Background: Somatostatin has been found to be effective in the prevention of postoperative complications in pancreatic surgery. It can inhibit the pancreatic secretions that, quite often, are responsible for complications during the postoperative period.

Methods: We randomized 67 patients in 2 groups. In the study group (n = 35), somatostatin was administered 30 minutes prior to surgery as well as intraoperatively and postoperatively. No medication was given to the control group (n = 32). Biopsies were taken and processed for electron microscopy and ultrastructural morphometric analysis.

Results: Administration of somatostatin reduced the exocrine granule number, and the patients suffered from fewer postoperative complications.

Conclusions: Somatostatin reduces granule number and size of pancreatic cells, which can partially explain the prophylactic effect of the drug on early complications of pancreatic surgery, and which is confirmed by the clinical findings.

No MeSH data available.


Related in: MedlinePlus