Limits...
Evaluation of therapeutic effects and serious complications following endoscopic obliterative therapy with Histoacryl.

Sato T, Yamazaki K - Clin Exp Gastroenterol (2010)

Bottom Line: Additional treatment was successfully performed in all recurrent cases.The two patients with splenic infarction improved with conservative medical treatment.Nonetheless, careful attention must be paid to avoid potentially serious complications.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Sapporo Kosei General Hospital, Sapporo, Japan.

ABSTRACT

Background and aims: Our aim was to evaluate the utility of endoscopic obliterative therapy with Histoacryl for gastric varices and to investigate the incidence of serious complications.

Methods: Endoscopic obliterative therapy with Histoacryl was performed on 129 gastric variceal patients. Sixty-five patients had cardiofornical varices, and 64 had fundal varices. Forty-five of 129 patients were emergency cases and the other 84 patients were prophylactic cases. Endoscopic therapy was performed under fluoroscopy using 70% Histoacryl (Histoacryl diluted with 5% Lipiodol).

Results: Endoscopic hemostasis of gastric varices was successful in 45/45 (100%) emergency cases. The recurrence rate of gastric varices was 17/120 (14.2%) among patients whose variceal eradication was achieved. Additional treatment was successfully performed in all recurrent cases. The incidence of serious complications was 4/129 (3.1%), including two cases of splenic infarction, one case of pulmonary embolism, and one case of an inflammatory tumor of pancreatic tail. The two patients with splenic infarction improved with conservative medical treatment. The patient with pulmonary embolism showed no respiratory symptoms, and died of liver failure. The patient with the pancreatic tumor, which was diagnosed as an inflammatory tumor, was treated surgically.

Conclusions: Endoscopic obliterative therapy with Histoacryl is a useful and relatively safe method for treatment of bleeding gastric varices. Nonetheless, careful attention must be paid to avoid potentially serious complications.

No MeSH data available.


Related in: MedlinePlus

Image of fluoroscopic observation with infusion of 70% Histoacryl to determine the extent of the varices.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3108656&req=5

f1b-ceg-3-091: Image of fluoroscopic observation with infusion of 70% Histoacryl to determine the extent of the varices.

Mentions: For endoscopic obliterative therapy for gastric varices, we used Histoacryl diluted to a final concentration of 70% in 5% Lipiodol (Guerbert, Roissy, France). Lipiodol prevents the tissue adhesive from polymerizing too quickly and also allows for radiographic monitoring. Obliterative therapy was performed repeatedly with a 23-gauge needle until gastric varices disappeared. Fluoroscopic observation with an infusion of 70% Histoacryl (avoiding flow into systemic circulation) was performed to determine the extent of the varices (Figure 1b). Gastric variceal recurrence was defined by red color sign on variceal surface or variceal bleeding.


Evaluation of therapeutic effects and serious complications following endoscopic obliterative therapy with Histoacryl.

Sato T, Yamazaki K - Clin Exp Gastroenterol (2010)

Image of fluoroscopic observation with infusion of 70% Histoacryl to determine the extent of the varices.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3108656&req=5

f1b-ceg-3-091: Image of fluoroscopic observation with infusion of 70% Histoacryl to determine the extent of the varices.
Mentions: For endoscopic obliterative therapy for gastric varices, we used Histoacryl diluted to a final concentration of 70% in 5% Lipiodol (Guerbert, Roissy, France). Lipiodol prevents the tissue adhesive from polymerizing too quickly and also allows for radiographic monitoring. Obliterative therapy was performed repeatedly with a 23-gauge needle until gastric varices disappeared. Fluoroscopic observation with an infusion of 70% Histoacryl (avoiding flow into systemic circulation) was performed to determine the extent of the varices (Figure 1b). Gastric variceal recurrence was defined by red color sign on variceal surface or variceal bleeding.

Bottom Line: Additional treatment was successfully performed in all recurrent cases.The two patients with splenic infarction improved with conservative medical treatment.Nonetheless, careful attention must be paid to avoid potentially serious complications.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Sapporo Kosei General Hospital, Sapporo, Japan.

ABSTRACT

Background and aims: Our aim was to evaluate the utility of endoscopic obliterative therapy with Histoacryl for gastric varices and to investigate the incidence of serious complications.

Methods: Endoscopic obliterative therapy with Histoacryl was performed on 129 gastric variceal patients. Sixty-five patients had cardiofornical varices, and 64 had fundal varices. Forty-five of 129 patients were emergency cases and the other 84 patients were prophylactic cases. Endoscopic therapy was performed under fluoroscopy using 70% Histoacryl (Histoacryl diluted with 5% Lipiodol).

Results: Endoscopic hemostasis of gastric varices was successful in 45/45 (100%) emergency cases. The recurrence rate of gastric varices was 17/120 (14.2%) among patients whose variceal eradication was achieved. Additional treatment was successfully performed in all recurrent cases. The incidence of serious complications was 4/129 (3.1%), including two cases of splenic infarction, one case of pulmonary embolism, and one case of an inflammatory tumor of pancreatic tail. The two patients with splenic infarction improved with conservative medical treatment. The patient with pulmonary embolism showed no respiratory symptoms, and died of liver failure. The patient with the pancreatic tumor, which was diagnosed as an inflammatory tumor, was treated surgically.

Conclusions: Endoscopic obliterative therapy with Histoacryl is a useful and relatively safe method for treatment of bleeding gastric varices. Nonetheless, careful attention must be paid to avoid potentially serious complications.

No MeSH data available.


Related in: MedlinePlus