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Efficacy and tolerability of Laxatan Granulat in patients with chronic constipation.

Gruenwald J, Busch R, Bentley C - Clin Exp Gastroenterol (2009)

Bottom Line: Changing nutrition habits or lifestyle is not always successful.In such cases, laxatives containing macrogol and inulin are highly effective.No adverse events were reported during this drug-monitoring study.

View Article: PubMed Central - PubMed

Affiliation: Analyze and Realize AG, Berlin, Germany.

ABSTRACT

Background: On average 12% of the population worldwide suffer from acute or chronic constipation. Pathological intestine alterations, an unhealthy diet with reduced liquid intake, and little exercise are potential reasons. Often the motility of the intestine is disturbed. Changing nutrition habits or lifestyle is not always successful. In such cases, laxatives containing macrogol and inulin are highly effective.

Methodology: The efficacy and tolerability of Laxatan(®) Granulat, a laxative containing macrogol, inulin, and mineral salts, was assessed in a drug-monitoring study of 105 patients for four weeks.

Results: At the end of this study, a highly significant reduction of the constipation symptoms in 98.1% of the patients was observed. No adverse events were reported during this drug-monitoring study. The overall efficacy was rated as being "very good" or "good" for 96% and the overall tolerability was rated as being "very good" or "good" for 99% of patients.

Conclusion: The combination of macrogol, inulin, and mineral salts is highly effective in the treatment of chronic constipation. Due to its prebiotic activity, inulin probably leads to proliferation of lactic acid-producing bacteria. The lowered pH and increased water content probably increases the peristaltic action and therefore reduces constipation.

No MeSH data available.


Related in: MedlinePlus

Scores at the first, second, and third examination.
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f2-ceg-2-095: Scores at the first, second, and third examination.

Mentions: Summation of the average scores of the seven individual symptoms resulted in the sum score for all symptoms as shown in Figure 2. This sum score clearly demonstrates a strong reduction of the constipation symptoms between the first, second, and third assessment. The value dropped from 14.5 ± 2.9 points at the beginning of the study to 4.6 ± 3.9 points by the end of the study, which represents an improvement rate of 68%. This result was statistically highly significant (P < 0.001)


Efficacy and tolerability of Laxatan Granulat in patients with chronic constipation.

Gruenwald J, Busch R, Bentley C - Clin Exp Gastroenterol (2009)

Scores at the first, second, and third examination.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3108648&req=5

f2-ceg-2-095: Scores at the first, second, and third examination.
Mentions: Summation of the average scores of the seven individual symptoms resulted in the sum score for all symptoms as shown in Figure 2. This sum score clearly demonstrates a strong reduction of the constipation symptoms between the first, second, and third assessment. The value dropped from 14.5 ± 2.9 points at the beginning of the study to 4.6 ± 3.9 points by the end of the study, which represents an improvement rate of 68%. This result was statistically highly significant (P < 0.001)

Bottom Line: Changing nutrition habits or lifestyle is not always successful.In such cases, laxatives containing macrogol and inulin are highly effective.No adverse events were reported during this drug-monitoring study.

View Article: PubMed Central - PubMed

Affiliation: Analyze and Realize AG, Berlin, Germany.

ABSTRACT

Background: On average 12% of the population worldwide suffer from acute or chronic constipation. Pathological intestine alterations, an unhealthy diet with reduced liquid intake, and little exercise are potential reasons. Often the motility of the intestine is disturbed. Changing nutrition habits or lifestyle is not always successful. In such cases, laxatives containing macrogol and inulin are highly effective.

Methodology: The efficacy and tolerability of Laxatan(®) Granulat, a laxative containing macrogol, inulin, and mineral salts, was assessed in a drug-monitoring study of 105 patients for four weeks.

Results: At the end of this study, a highly significant reduction of the constipation symptoms in 98.1% of the patients was observed. No adverse events were reported during this drug-monitoring study. The overall efficacy was rated as being "very good" or "good" for 96% and the overall tolerability was rated as being "very good" or "good" for 99% of patients.

Conclusion: The combination of macrogol, inulin, and mineral salts is highly effective in the treatment of chronic constipation. Due to its prebiotic activity, inulin probably leads to proliferation of lactic acid-producing bacteria. The lowered pH and increased water content probably increases the peristaltic action and therefore reduces constipation.

No MeSH data available.


Related in: MedlinePlus