Limits...
Response to chemoradiatiotherapy in squamous cell carcinoma of the esophagus: evaluation of some prognostic factors.

Stockeld D, Falkmer U, Falkmer S, Backman L, Granström L, Fagerberg J - Clin Exp Gastroenterol (2009)

Bottom Line: A positive correlation was found between factor VIII expression and a complete tumor response (p = 0.0357).However the other marker for angiogenesis, CD-34, showed a negative correlation (p = 0.0493).In spite of significant correlations between complete tumor responses and the expressions of the markers for angiogenesis this significance may be questionable since one of the two markers, factor VIII had a positive and the other,CD-34, a negative correlation to tumor response.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Danderyd Hospital, Stockholm, Sweden;

ABSTRACT

Objective: To evaluate the predictive values of the expression of factor VIII, CD-34, p53, bcl-2, and DNA ploidy regarding the response to chemoradiation of squamous cell carcinoma of the esophagus.

Design: Retrospective analysis of pretreatment biopsies with immunohistochemistry and flow cytometry. The results were correlated to tumor response (complete vs. noncomplete) following chemoradiation with three cycles of 5-FU and cisplatin combined with 40-64 Gy of radiation.

Subjects: 44 consecutive patients with squamous cell carcinoma of the esophagus treated with chemoradiation with a curative intent from 1992-2000.

Main outcome measures: Treatment response.

Results: No correlations were found between the expressions of p53, bcl-2, or DNA ploidy and tumor response to chemoradiation. A positive correlation was found between factor VIII expression and a complete tumor response (p = 0.0357). However the other marker for angiogenesis, CD-34, showed a negative correlation (p = 0.0493). Both markers indicate blood vessel density meaning that, in this study, many vessels indicated a favorable response if measured with factor VIII, but a poor response if measured with CD-34.

Conclusion: It is not possible to predict tumor response to our chemoradiation protocol through the analysis of pretreatment expression of p53, bcl-2 or DNA ploidy in biopsy specimens. In spite of significant correlations between complete tumor responses and the expressions of the markers for angiogenesis this significance may be questionable since one of the two markers, factor VIII had a positive and the other,CD-34, a negative correlation to tumor response.

No MeSH data available.


Related in: MedlinePlus

Oncological treatment protocol.Abbreviations: Chemo, chemotherapy; RT, radiotherapy.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3108642&req=5

f1-ceg-2-041: Oncological treatment protocol.Abbreviations: Chemo, chemotherapy; RT, radiotherapy.

Mentions: The protocol6 included three five-day courses of cisplatinum (100 mg/m2 on the first day of each course) and 5-fluorouracil (a continuous 120-hour infusion on day 1 through 5 of each course with 750 mg/m2 administered on each day of treatment) with a two-week rest between the treatments. Radiation was administered daily on weekdays from the first day of the second course of chemotherapy up to a preoperative dose of 40 Gy or through a full dose treatment of 64 Gy. The radiation treatment (preoperative or full dose) was decided on before the treatment started. The daily fractionation was 2 Gy (see Figure 1).


Response to chemoradiatiotherapy in squamous cell carcinoma of the esophagus: evaluation of some prognostic factors.

Stockeld D, Falkmer U, Falkmer S, Backman L, Granström L, Fagerberg J - Clin Exp Gastroenterol (2009)

Oncological treatment protocol.Abbreviations: Chemo, chemotherapy; RT, radiotherapy.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3108642&req=5

f1-ceg-2-041: Oncological treatment protocol.Abbreviations: Chemo, chemotherapy; RT, radiotherapy.
Mentions: The protocol6 included three five-day courses of cisplatinum (100 mg/m2 on the first day of each course) and 5-fluorouracil (a continuous 120-hour infusion on day 1 through 5 of each course with 750 mg/m2 administered on each day of treatment) with a two-week rest between the treatments. Radiation was administered daily on weekdays from the first day of the second course of chemotherapy up to a preoperative dose of 40 Gy or through a full dose treatment of 64 Gy. The radiation treatment (preoperative or full dose) was decided on before the treatment started. The daily fractionation was 2 Gy (see Figure 1).

Bottom Line: A positive correlation was found between factor VIII expression and a complete tumor response (p = 0.0357).However the other marker for angiogenesis, CD-34, showed a negative correlation (p = 0.0493).In spite of significant correlations between complete tumor responses and the expressions of the markers for angiogenesis this significance may be questionable since one of the two markers, factor VIII had a positive and the other,CD-34, a negative correlation to tumor response.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Danderyd Hospital, Stockholm, Sweden;

ABSTRACT

Objective: To evaluate the predictive values of the expression of factor VIII, CD-34, p53, bcl-2, and DNA ploidy regarding the response to chemoradiation of squamous cell carcinoma of the esophagus.

Design: Retrospective analysis of pretreatment biopsies with immunohistochemistry and flow cytometry. The results were correlated to tumor response (complete vs. noncomplete) following chemoradiation with three cycles of 5-FU and cisplatin combined with 40-64 Gy of radiation.

Subjects: 44 consecutive patients with squamous cell carcinoma of the esophagus treated with chemoradiation with a curative intent from 1992-2000.

Main outcome measures: Treatment response.

Results: No correlations were found between the expressions of p53, bcl-2, or DNA ploidy and tumor response to chemoradiation. A positive correlation was found between factor VIII expression and a complete tumor response (p = 0.0357). However the other marker for angiogenesis, CD-34, showed a negative correlation (p = 0.0493). Both markers indicate blood vessel density meaning that, in this study, many vessels indicated a favorable response if measured with factor VIII, but a poor response if measured with CD-34.

Conclusion: It is not possible to predict tumor response to our chemoradiation protocol through the analysis of pretreatment expression of p53, bcl-2 or DNA ploidy in biopsy specimens. In spite of significant correlations between complete tumor responses and the expressions of the markers for angiogenesis this significance may be questionable since one of the two markers, factor VIII had a positive and the other,CD-34, a negative correlation to tumor response.

No MeSH data available.


Related in: MedlinePlus