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Anti-inflammatory and immunomodulatory effects of paeonia lactiflora pall., a traditional chinese herbal medicine.

He DY, Dai SM - Front Pharmacol (2011)

Bottom Line: The analgesic effect of TGP was confirmed in various animal models of pain, which may be mediated partly by adenosine A1 receptor.TGP was also reported to have protective effects of cells against oxidative stress.In adjuvant arthritis rats, paeoniflorin exerted immunosuppressive effects.

View Article: PubMed Central - PubMed

Affiliation: Department of Rheumatology, Shanghai Guanghua Hospital Shanghai, China.

ABSTRACT
In China, Korea, and Japan, a decoction of the dried root without bark of Paeonia lactiflora Pall. has been used in the treatment of rheumatoid arthritis, systemic lupus erythematosus, hepatitis, dysmenorrhea, muscle cramping and spasms, and fever for more than 1200 years. A water/ethanol extract of the root is now known as total glucosides of peony (TGP), which contains more than 15 components. Paeoniflorin is the most abundant ingredient and accounts for the pharmacological effects observed with TGP in both in vitro and in vivo studies. The analgesic effect of TGP was confirmed in various animal models of pain, which may be mediated partly by adenosine A1 receptor. The direct anti-inflammatory effects of TGP were observed in animal models of both acute and subacute inflammation, by inhibiting the production of prostaglandin E2, leukotriene B4, and nitric oxide, and by suppressing the increase of intracellular calcium ion concentration. TGP was also reported to have protective effects of cells against oxidative stress. In vitro, dual effects of TGP were noted on the proliferation of lymphocytes, differentiation of Th/Ts lymphocytes, and the production of proinflammatory cytokines and antibodies. In vivo, TGP inhibited the delayed-type hypersensitivity in immuno-activated mice, and enhanced the delayed-type hypersensitivity in immuno-suppressed mice. In adjuvant arthritis rats, paeoniflorin exerted immunosuppressive effects. The beneficial effects of TGP in treating rheumatoid arthritis were verified by randomized controlled trials. The adverse events of TGP were mainly gastrointestinal tract disturbances, mostly mild diarrhea.

No MeSH data available.


Related in: MedlinePlus

Paeonia lactiflora Pall. (A) overground part of the plant; (B) root; (C) scheme of an intact plant.
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Figure 1: Paeonia lactiflora Pall. (A) overground part of the plant; (B) root; (C) scheme of an intact plant.

Mentions: Paeoniae Radix is one of the most well-known herbs in China, Korea, and Japan for more than 1200 years. Paeonies are divided into two groups: the tree Peony (also named Paeonia Moutan) and the herbaceous kinds. Paeonia lactiflora Pall. (also named Chinese Peony) is a herbaceous perennial flowering plant in the family Paeoniaceae with fleshy roots and annual stems. It is about 60–100 cm tall with large compound leaves 20–40 cm long. The flower buds are large and round, opening into large flowers 8–16 cm diameter, with 5–10 white, pink, or crimson petals and yellow stamens (Figure 1). It is native to east Asia, and is grown on dry open stony slopes, riverbanks and sparse woodland edges.


Anti-inflammatory and immunomodulatory effects of paeonia lactiflora pall., a traditional chinese herbal medicine.

He DY, Dai SM - Front Pharmacol (2011)

Paeonia lactiflora Pall. (A) overground part of the plant; (B) root; (C) scheme of an intact plant.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108611&req=5

Figure 1: Paeonia lactiflora Pall. (A) overground part of the plant; (B) root; (C) scheme of an intact plant.
Mentions: Paeoniae Radix is one of the most well-known herbs in China, Korea, and Japan for more than 1200 years. Paeonies are divided into two groups: the tree Peony (also named Paeonia Moutan) and the herbaceous kinds. Paeonia lactiflora Pall. (also named Chinese Peony) is a herbaceous perennial flowering plant in the family Paeoniaceae with fleshy roots and annual stems. It is about 60–100 cm tall with large compound leaves 20–40 cm long. The flower buds are large and round, opening into large flowers 8–16 cm diameter, with 5–10 white, pink, or crimson petals and yellow stamens (Figure 1). It is native to east Asia, and is grown on dry open stony slopes, riverbanks and sparse woodland edges.

Bottom Line: The analgesic effect of TGP was confirmed in various animal models of pain, which may be mediated partly by adenosine A1 receptor.TGP was also reported to have protective effects of cells against oxidative stress.In adjuvant arthritis rats, paeoniflorin exerted immunosuppressive effects.

View Article: PubMed Central - PubMed

Affiliation: Department of Rheumatology, Shanghai Guanghua Hospital Shanghai, China.

ABSTRACT
In China, Korea, and Japan, a decoction of the dried root without bark of Paeonia lactiflora Pall. has been used in the treatment of rheumatoid arthritis, systemic lupus erythematosus, hepatitis, dysmenorrhea, muscle cramping and spasms, and fever for more than 1200 years. A water/ethanol extract of the root is now known as total glucosides of peony (TGP), which contains more than 15 components. Paeoniflorin is the most abundant ingredient and accounts for the pharmacological effects observed with TGP in both in vitro and in vivo studies. The analgesic effect of TGP was confirmed in various animal models of pain, which may be mediated partly by adenosine A1 receptor. The direct anti-inflammatory effects of TGP were observed in animal models of both acute and subacute inflammation, by inhibiting the production of prostaglandin E2, leukotriene B4, and nitric oxide, and by suppressing the increase of intracellular calcium ion concentration. TGP was also reported to have protective effects of cells against oxidative stress. In vitro, dual effects of TGP were noted on the proliferation of lymphocytes, differentiation of Th/Ts lymphocytes, and the production of proinflammatory cytokines and antibodies. In vivo, TGP inhibited the delayed-type hypersensitivity in immuno-activated mice, and enhanced the delayed-type hypersensitivity in immuno-suppressed mice. In adjuvant arthritis rats, paeoniflorin exerted immunosuppressive effects. The beneficial effects of TGP in treating rheumatoid arthritis were verified by randomized controlled trials. The adverse events of TGP were mainly gastrointestinal tract disturbances, mostly mild diarrhea.

No MeSH data available.


Related in: MedlinePlus