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Comparison of fine needle aspiration cytology and thyroid scan in solitary thyroid nodule.

Basharat R, Bukhari MH, Saeed S, Hamid T - Patholog Res Int (2011)

Bottom Line: Results.On histopathology, 45 patients (90%) were confirmed to have benign lesions and 5 patients (10%), malignant lesions.Fine needle aspiration was a significantly better predictor of malignancy than thyroid scan and resulted in a smaller proportion of excisions for benign nodules.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, King Edward Medical University, Lahore 54000, Pakistan.

ABSTRACT
Objective. This was a comparative study between FNAC and thyroid scan used to diagnose the solitary thyroid nodule and histopathology was used as gold standard to compare the results of both modalities. We hypothesized that Fine needle aspiration cytology and thyroid scan diagnose solitary thyroid nodule (STN) as accurately as histopathology. Materials and Methods. This study comprised of 50 patients with solitary thyroid nodules (STN) presented to OPD. After clinical examination these patients were referred to Centre for Nuclear Medicine, Mayo Hospital Lahore for thyroid function tests and thyroid scan (TS). These patients underwent FNAC in the department of Pathology and surgery in Mayo Hospital. The cases were operated and evaluated for histopathological changes. Results. On thyroid scan, 40 patients (80%) having cold nodule were labeled as suspicious 10 patients (20%) had hot nodule. On FNAC 23 patients (46%) had benign lesion, 22 patients (44%) had indeterminate lesion and 5 patients (10%) had malignant lesions. On histopathology, 45 patients (90%) were confirmed to have benign lesions and 5 patients (10%), malignant lesions. After comparison of results of thyroid scan and FNAC with histopathology, the sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of thyroid scan were 80%, 20%, 10%, 90% and 26%, respectively whereas those of FNAC were 80%, 97.7%, 80%, 97.7% and 96%, respectively. Conclusion. Fine needle aspiration was a significantly better predictor of malignancy than thyroid scan and resulted in a smaller proportion of excisions for benign nodules.

No MeSH data available.


Related in: MedlinePlus

(a) Photomicrograph on FNAC (Pap stain 40x), anaplastic carcinoma showing  pleomorphism in size and shape with giant or multinucleate forms, prominent nucleoli, nuclear inclusions, and vacuolated cytoplasm. (b) Histopathology (10x H&E) of anaplastic carcinoma. (c) FNAC (Pap stain 20x) of colloid goiter showing macrophages and uniform cuboidal cells of thyroid follicles. (d) Histopathology of colloid goiter (H&E 40x).
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fig5: (a) Photomicrograph on FNAC (Pap stain 40x), anaplastic carcinoma showing pleomorphism in size and shape with giant or multinucleate forms, prominent nucleoli, nuclear inclusions, and vacuolated cytoplasm. (b) Histopathology (10x H&E) of anaplastic carcinoma. (c) FNAC (Pap stain 20x) of colloid goiter showing macrophages and uniform cuboidal cells of thyroid follicles. (d) Histopathology of colloid goiter (H&E 40x).

Mentions: Morphological comparison of different lesions on FNAC and Histopathology is shown in Figures 2–5.


Comparison of fine needle aspiration cytology and thyroid scan in solitary thyroid nodule.

Basharat R, Bukhari MH, Saeed S, Hamid T - Patholog Res Int (2011)

(a) Photomicrograph on FNAC (Pap stain 40x), anaplastic carcinoma showing  pleomorphism in size and shape with giant or multinucleate forms, prominent nucleoli, nuclear inclusions, and vacuolated cytoplasm. (b) Histopathology (10x H&E) of anaplastic carcinoma. (c) FNAC (Pap stain 20x) of colloid goiter showing macrophages and uniform cuboidal cells of thyroid follicles. (d) Histopathology of colloid goiter (H&E 40x).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3108561&req=5

fig5: (a) Photomicrograph on FNAC (Pap stain 40x), anaplastic carcinoma showing pleomorphism in size and shape with giant or multinucleate forms, prominent nucleoli, nuclear inclusions, and vacuolated cytoplasm. (b) Histopathology (10x H&E) of anaplastic carcinoma. (c) FNAC (Pap stain 20x) of colloid goiter showing macrophages and uniform cuboidal cells of thyroid follicles. (d) Histopathology of colloid goiter (H&E 40x).
Mentions: Morphological comparison of different lesions on FNAC and Histopathology is shown in Figures 2–5.

Bottom Line: Results.On histopathology, 45 patients (90%) were confirmed to have benign lesions and 5 patients (10%), malignant lesions.Fine needle aspiration was a significantly better predictor of malignancy than thyroid scan and resulted in a smaller proportion of excisions for benign nodules.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, King Edward Medical University, Lahore 54000, Pakistan.

ABSTRACT
Objective. This was a comparative study between FNAC and thyroid scan used to diagnose the solitary thyroid nodule and histopathology was used as gold standard to compare the results of both modalities. We hypothesized that Fine needle aspiration cytology and thyroid scan diagnose solitary thyroid nodule (STN) as accurately as histopathology. Materials and Methods. This study comprised of 50 patients with solitary thyroid nodules (STN) presented to OPD. After clinical examination these patients were referred to Centre for Nuclear Medicine, Mayo Hospital Lahore for thyroid function tests and thyroid scan (TS). These patients underwent FNAC in the department of Pathology and surgery in Mayo Hospital. The cases were operated and evaluated for histopathological changes. Results. On thyroid scan, 40 patients (80%) having cold nodule were labeled as suspicious 10 patients (20%) had hot nodule. On FNAC 23 patients (46%) had benign lesion, 22 patients (44%) had indeterminate lesion and 5 patients (10%) had malignant lesions. On histopathology, 45 patients (90%) were confirmed to have benign lesions and 5 patients (10%), malignant lesions. After comparison of results of thyroid scan and FNAC with histopathology, the sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of thyroid scan were 80%, 20%, 10%, 90% and 26%, respectively whereas those of FNAC were 80%, 97.7%, 80%, 97.7% and 96%, respectively. Conclusion. Fine needle aspiration was a significantly better predictor of malignancy than thyroid scan and resulted in a smaller proportion of excisions for benign nodules.

No MeSH data available.


Related in: MedlinePlus