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Comparison of fine needle aspiration cytology and thyroid scan in solitary thyroid nodule.

Basharat R, Bukhari MH, Saeed S, Hamid T - Patholog Res Int (2011)

Bottom Line: Results.On histopathology, 45 patients (90%) were confirmed to have benign lesions and 5 patients (10%), malignant lesions.Fine needle aspiration was a significantly better predictor of malignancy than thyroid scan and resulted in a smaller proportion of excisions for benign nodules.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, King Edward Medical University, Lahore 54000, Pakistan.

ABSTRACT
Objective. This was a comparative study between FNAC and thyroid scan used to diagnose the solitary thyroid nodule and histopathology was used as gold standard to compare the results of both modalities. We hypothesized that Fine needle aspiration cytology and thyroid scan diagnose solitary thyroid nodule (STN) as accurately as histopathology. Materials and Methods. This study comprised of 50 patients with solitary thyroid nodules (STN) presented to OPD. After clinical examination these patients were referred to Centre for Nuclear Medicine, Mayo Hospital Lahore for thyroid function tests and thyroid scan (TS). These patients underwent FNAC in the department of Pathology and surgery in Mayo Hospital. The cases were operated and evaluated for histopathological changes. Results. On thyroid scan, 40 patients (80%) having cold nodule were labeled as suspicious 10 patients (20%) had hot nodule. On FNAC 23 patients (46%) had benign lesion, 22 patients (44%) had indeterminate lesion and 5 patients (10%) had malignant lesions. On histopathology, 45 patients (90%) were confirmed to have benign lesions and 5 patients (10%), malignant lesions. After comparison of results of thyroid scan and FNAC with histopathology, the sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of thyroid scan were 80%, 20%, 10%, 90% and 26%, respectively whereas those of FNAC were 80%, 97.7%, 80%, 97.7% and 96%, respectively. Conclusion. Fine needle aspiration was a significantly better predictor of malignancy than thyroid scan and resulted in a smaller proportion of excisions for benign nodules.

No MeSH data available.


Related in: MedlinePlus

Photomicrograph of FNAC (a) and (b) (H&E) follicular neoplasms, showing  marked cellularity,   discohesion, single cells, Predominantly microfollicles    and/or trabeculae,  uniformly enlarged cells,   crowding,  scant colloid,   marked nuclear atypia, mitosis    and necrosis is uncommon. (c) Histopathology (H&E 10x) of follicular carcinoma showing capsular (thin arrow) and vascular invasion (thick arrow). (d) Follicular adenoma, (H&E 10x) where no capsular invasion is seen while histologic evidence of invasion is the gold standard of malignancy for the follicular lesions.
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fig2: Photomicrograph of FNAC (a) and (b) (H&E) follicular neoplasms, showing marked cellularity, discohesion, single cells, Predominantly microfollicles and/or trabeculae, uniformly enlarged cells, crowding, scant colloid, marked nuclear atypia, mitosis and necrosis is uncommon. (c) Histopathology (H&E 10x) of follicular carcinoma showing capsular (thin arrow) and vascular invasion (thick arrow). (d) Follicular adenoma, (H&E 10x) where no capsular invasion is seen while histologic evidence of invasion is the gold standard of malignancy for the follicular lesions.

Mentions: Morphological comparison of different lesions on FNAC and Histopathology is shown in Figures 2–5.


Comparison of fine needle aspiration cytology and thyroid scan in solitary thyroid nodule.

Basharat R, Bukhari MH, Saeed S, Hamid T - Patholog Res Int (2011)

Photomicrograph of FNAC (a) and (b) (H&E) follicular neoplasms, showing  marked cellularity,   discohesion, single cells, Predominantly microfollicles    and/or trabeculae,  uniformly enlarged cells,   crowding,  scant colloid,   marked nuclear atypia, mitosis    and necrosis is uncommon. (c) Histopathology (H&E 10x) of follicular carcinoma showing capsular (thin arrow) and vascular invasion (thick arrow). (d) Follicular adenoma, (H&E 10x) where no capsular invasion is seen while histologic evidence of invasion is the gold standard of malignancy for the follicular lesions.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3108561&req=5

fig2: Photomicrograph of FNAC (a) and (b) (H&E) follicular neoplasms, showing marked cellularity, discohesion, single cells, Predominantly microfollicles and/or trabeculae, uniformly enlarged cells, crowding, scant colloid, marked nuclear atypia, mitosis and necrosis is uncommon. (c) Histopathology (H&E 10x) of follicular carcinoma showing capsular (thin arrow) and vascular invasion (thick arrow). (d) Follicular adenoma, (H&E 10x) where no capsular invasion is seen while histologic evidence of invasion is the gold standard of malignancy for the follicular lesions.
Mentions: Morphological comparison of different lesions on FNAC and Histopathology is shown in Figures 2–5.

Bottom Line: Results.On histopathology, 45 patients (90%) were confirmed to have benign lesions and 5 patients (10%), malignant lesions.Fine needle aspiration was a significantly better predictor of malignancy than thyroid scan and resulted in a smaller proportion of excisions for benign nodules.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, King Edward Medical University, Lahore 54000, Pakistan.

ABSTRACT
Objective. This was a comparative study between FNAC and thyroid scan used to diagnose the solitary thyroid nodule and histopathology was used as gold standard to compare the results of both modalities. We hypothesized that Fine needle aspiration cytology and thyroid scan diagnose solitary thyroid nodule (STN) as accurately as histopathology. Materials and Methods. This study comprised of 50 patients with solitary thyroid nodules (STN) presented to OPD. After clinical examination these patients were referred to Centre for Nuclear Medicine, Mayo Hospital Lahore for thyroid function tests and thyroid scan (TS). These patients underwent FNAC in the department of Pathology and surgery in Mayo Hospital. The cases were operated and evaluated for histopathological changes. Results. On thyroid scan, 40 patients (80%) having cold nodule were labeled as suspicious 10 patients (20%) had hot nodule. On FNAC 23 patients (46%) had benign lesion, 22 patients (44%) had indeterminate lesion and 5 patients (10%) had malignant lesions. On histopathology, 45 patients (90%) were confirmed to have benign lesions and 5 patients (10%), malignant lesions. After comparison of results of thyroid scan and FNAC with histopathology, the sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of thyroid scan were 80%, 20%, 10%, 90% and 26%, respectively whereas those of FNAC were 80%, 97.7%, 80%, 97.7% and 96%, respectively. Conclusion. Fine needle aspiration was a significantly better predictor of malignancy than thyroid scan and resulted in a smaller proportion of excisions for benign nodules.

No MeSH data available.


Related in: MedlinePlus