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Perisylvian Functional Connectivity during Processing of Sentential Negation.

Bahlmann J, Mueller JL, Makuuchi M, Friederici AD - Front Psychol (2011)

Bottom Line: As a result, we found a network including the left inferior frontal gyrus (pars triangularis, BA 45), and the left inferior parietal gyrus (BA 40) to be activated whenever negations in the main clause had to be processed.Additionally, we found increased functional coupling between the left pars triangularis (BA 45), left pars opercularis (BA 44), left SMA (BA 6), and left superior temporal gyrus (BA 42) during the processing of main clause negations.Thus, the results indicate that the left perisylvian language network synchronizes in order to resolve negations, in particular, whenever requirements on meaning integration are enhanced.

View Article: PubMed Central - PubMed

Affiliation: Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Germany.

ABSTRACT
Every language has the means to reverse the truth value of a sentence by using specific linguistic markers of negation. In the present study we investigated the neural processing costs afforded by the construction of meaning in German sentences containing negation in different clause types. We studied negations within and across clause boundaries as well as single and double negations. Participants read German sentences comprising of affirmations, single negations in the main or in the subordinate clause, or double negations. As a result, we found a network including the left inferior frontal gyrus (pars triangularis, BA 45), and the left inferior parietal gyrus (BA 40) to be activated whenever negations in the main clause had to be processed. Additionally, we found increased functional coupling between the left pars triangularis (BA 45), left pars opercularis (BA 44), left SMA (BA 6), and left superior temporal gyrus (BA 42) during the processing of main clause negations. The study shows that in order to process negations that require semantic integration across clause boundaries left BA 45 interplays with other areas that have been related to language processing and/or the processing of cognitive demands and logical/conditional reasoning. Thus, the results indicate that the left perisylvian language network synchronizes in order to resolve negations, in particular, whenever requirements on meaning integration are enhanced.

No MeSH data available.


Psychophysiological interaction analysis of negation. Illustration of the functional coupling between the seed region pars triangularis (BA 45) and the pars opercularis (BA 44), the left STG, and the SMA. The processing of negations triggers the coupling of the hemodynamic response between the brain regions.
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Figure 5: Psychophysiological interaction analysis of negation. Illustration of the functional coupling between the seed region pars triangularis (BA 45) and the pars opercularis (BA 44), the left STG, and the SMA. The processing of negations triggers the coupling of the hemodynamic response between the brain regions.

Mentions: The PPI analysis with seed in the left IFG (BA 45) revealed three brain areas, namely left superior temporal gyrus (BA 42), (left) supplementary motor area (BA 6), and left IFG (BA 44/48), see Table 3 and Figure 5 which showed a significant increased functional coupling in the context of negation in the main clause. The opposite contrast – context of affirmation in the main clause – did not show any significantly activated (functionally coupled) brain areas.


Perisylvian Functional Connectivity during Processing of Sentential Negation.

Bahlmann J, Mueller JL, Makuuchi M, Friederici AD - Front Psychol (2011)

Psychophysiological interaction analysis of negation. Illustration of the functional coupling between the seed region pars triangularis (BA 45) and the pars opercularis (BA 44), the left STG, and the SMA. The processing of negations triggers the coupling of the hemodynamic response between the brain regions.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3108559&req=5

Figure 5: Psychophysiological interaction analysis of negation. Illustration of the functional coupling between the seed region pars triangularis (BA 45) and the pars opercularis (BA 44), the left STG, and the SMA. The processing of negations triggers the coupling of the hemodynamic response between the brain regions.
Mentions: The PPI analysis with seed in the left IFG (BA 45) revealed three brain areas, namely left superior temporal gyrus (BA 42), (left) supplementary motor area (BA 6), and left IFG (BA 44/48), see Table 3 and Figure 5 which showed a significant increased functional coupling in the context of negation in the main clause. The opposite contrast – context of affirmation in the main clause – did not show any significantly activated (functionally coupled) brain areas.

Bottom Line: As a result, we found a network including the left inferior frontal gyrus (pars triangularis, BA 45), and the left inferior parietal gyrus (BA 40) to be activated whenever negations in the main clause had to be processed.Additionally, we found increased functional coupling between the left pars triangularis (BA 45), left pars opercularis (BA 44), left SMA (BA 6), and left superior temporal gyrus (BA 42) during the processing of main clause negations.Thus, the results indicate that the left perisylvian language network synchronizes in order to resolve negations, in particular, whenever requirements on meaning integration are enhanced.

View Article: PubMed Central - PubMed

Affiliation: Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Germany.

ABSTRACT
Every language has the means to reverse the truth value of a sentence by using specific linguistic markers of negation. In the present study we investigated the neural processing costs afforded by the construction of meaning in German sentences containing negation in different clause types. We studied negations within and across clause boundaries as well as single and double negations. Participants read German sentences comprising of affirmations, single negations in the main or in the subordinate clause, or double negations. As a result, we found a network including the left inferior frontal gyrus (pars triangularis, BA 45), and the left inferior parietal gyrus (BA 40) to be activated whenever negations in the main clause had to be processed. Additionally, we found increased functional coupling between the left pars triangularis (BA 45), left pars opercularis (BA 44), left SMA (BA 6), and left superior temporal gyrus (BA 42) during the processing of main clause negations. The study shows that in order to process negations that require semantic integration across clause boundaries left BA 45 interplays with other areas that have been related to language processing and/or the processing of cognitive demands and logical/conditional reasoning. Thus, the results indicate that the left perisylvian language network synchronizes in order to resolve negations, in particular, whenever requirements on meaning integration are enhanced.

No MeSH data available.